Polyketides with a 6/6/6/6 Oxaphenalene Pyranone Skeleton from Marine-Derived <i>Streptomyces</i> sp. HDN150000

Polyketides with a 6/6/6/6 Oxaphenalene Pyranone Skeleton from Marine-Derived <i>Streptomyces</i> sp. HDN150000

Three new structures named naphpyrone I–K (<b>1</b>–<b>3</b>) that contain a 6/6/6/6 oxaphenalene pyranone skeleton were isolated and purified from a marine-derived <i>Streptomyces</i> sp. HDN155000. Their chemical structures, including configurations, were elucid...

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Bibliographic Details
Main Authors: Xiaoting Zhang, Falei Zhang, Wenxue Wang, Xingtao Ren, Tianjiao Zhu, Qian Che, Dehai Li, Guojian Zhang
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Marine Drugs
Subjects:
actinobacteria
polyketide
cytotoxic activity
Online Access:https://www.mdpi.com/1660-3397/23/5/188
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Summary:Three new structures named naphpyrone I–K (<b>1</b>–<b>3</b>) that contain a 6/6/6/6 oxaphenalene pyranone skeleton were isolated and purified from a marine-derived <i>Streptomyces</i> sp. HDN155000. Their chemical structures, including configurations, were elucidated by extensive NMR, MS, single-crystal X-ray diffraction, theoretical NMR calculations, DP4+ probability analysis, and ECD analyses. Naphpyrone K (<b>3</b>) showed cytotoxic activities against L-02, K562, NCI-H446/EP, MDA-MB-231, and NCI-H446 cancer cells with IC<sub>50</sub> values of 5.13, 3.34, 2.50, 2.61, and 2.20 μM, respectively. These findings highlight the potential for screening and developing therapeutic drugs from aromatic polyketides derived from marine actinobacteria.
ISSN:1660-3397

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