Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage
The p53 tumor suppressor induces the transcription of genes that negatively regulate progression of the cell cycle in response to DNA damage or other cellular stressors and thus participates in maintaining genome stability. Numerous studies have demonstrated that p53 transcription is activated befor...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/808934 |
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| _version_ | 1832556590898610176 |
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| author | David Reisman Paula Takahashi Amanda Polson Kristy Boggs |
| author_facet | David Reisman Paula Takahashi Amanda Polson Kristy Boggs |
| author_sort | David Reisman |
| collection | DOAJ |
| description | The p53 tumor suppressor induces the transcription of genes that negatively regulate progression of the cell cycle in response to DNA damage or other cellular stressors and thus participates in maintaining genome stability. Numerous studies have demonstrated that p53 transcription is activated before or during early S-phase in cells progressing from G0/G1 into S-phase through the combined action of two DNA-binding factors RBP-Jκ and C/EBPβ-2. Here, we review evidence that this induction occurs to provide available p53 mRNA in order to prepare the cell for DNA damage in S-phase, this ensuring a rapid response to DNA damage before exiting this stage of the cell cycle. |
| format | Article |
| id | doaj-art-0e5d590edc224652bfd2a253b02bf639 |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-0e5d590edc224652bfd2a253b02bf6392025-02-03T05:44:52ZengWileyBiochemistry Research International2090-22472090-22552012-01-01201210.1155/2012/808934808934Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA DamageDavid Reisman0Paula Takahashi1Amanda Polson2Kristy Boggs3Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USADepartamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, BrazilDepartment of Biological Sciences, University of South Carolina, Columbia, SC 29208, USADepartment of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USAThe p53 tumor suppressor induces the transcription of genes that negatively regulate progression of the cell cycle in response to DNA damage or other cellular stressors and thus participates in maintaining genome stability. Numerous studies have demonstrated that p53 transcription is activated before or during early S-phase in cells progressing from G0/G1 into S-phase through the combined action of two DNA-binding factors RBP-Jκ and C/EBPβ-2. Here, we review evidence that this induction occurs to provide available p53 mRNA in order to prepare the cell for DNA damage in S-phase, this ensuring a rapid response to DNA damage before exiting this stage of the cell cycle.http://dx.doi.org/10.1155/2012/808934 |
| spellingShingle | David Reisman Paula Takahashi Amanda Polson Kristy Boggs Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage Biochemistry Research International |
| title | Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage |
| title_full | Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage |
| title_fullStr | Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage |
| title_full_unstemmed | Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage |
| title_short | Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage |
| title_sort | transcriptional regulation of the p53 tumor suppressor gene in s phase of the cell cycle and the cellular response to dna damage |
| url | http://dx.doi.org/10.1155/2012/808934 |
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