Gut Microbiota-Immune System Crosstalk and Pancreatic Disorders
Gut microbiota is key to the development and modulation of the mucosal immune system. It plays a central role in several physiological functions, in the modulation of inflammatory signaling and in the protection against infections. In healthy states, there is a perfect balance between commensal and...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/7946431 |
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| author | D. Pagliari A. Saviano E. E. Newton M. L. Serricchio A. A. Dal Lago A. Gasbarrini R. Cianci |
| author_facet | D. Pagliari A. Saviano E. E. Newton M. L. Serricchio A. A. Dal Lago A. Gasbarrini R. Cianci |
| author_sort | D. Pagliari |
| collection | DOAJ |
| description | Gut microbiota is key to the development and modulation of the mucosal immune system. It plays a central role in several physiological functions, in the modulation of inflammatory signaling and in the protection against infections. In healthy states, there is a perfect balance between commensal and pathogens, and microbiota and the immune system interact to maintain gut homeostasis. The alteration of such balance, called dysbiosis, determines an intestinal bacterial overgrowth which leads to the disruption of the intestinal barrier with systemic translocation of pathogens. The pancreas does not possess its own microbiota, and it is believed that inflammatory and neoplastic processes affecting the gland may be linked to intestinal dysbiosis. Increasing research evidence testifies a correlation between intestinal dysbiosis and various pancreatic disorders, but it remains unclear whether dysbiosis is the cause or an effect. The analysis of specific alterations in the microbiome profile may permit to develop novel tools for the early detection of several pancreatic disorders, utilizing samples, such as blood, saliva, and stools. Future studies will have to elucidate the mechanisms by which gut microbiota is modulated and how it tunes the immune system, in order to be able to develop innovative treatment strategies for pancreatic disorders. |
| format | Article |
| id | doaj-art-0e59579e427c44d194a316911bc75aa5 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0e59579e427c44d194a316911bc75aa52025-02-03T06:15:12ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/79464317946431Gut Microbiota-Immune System Crosstalk and Pancreatic DisordersD. Pagliari0A. Saviano1E. E. Newton2M. L. Serricchio3A. A. Dal Lago4A. Gasbarrini5R. Cianci6Department of Gastroenterology, Pancreatic Unit, Catholic University of the Sacred Heart School of Medicine, Rome, ItalyDepartment of Gastroenterology, Pancreatic Unit, Catholic University of the Sacred Heart School of Medicine, Rome, ItalyCytoCure LLC, Beverly, MA, USADepartment of Gastroenterology, Pancreatic Unit, Catholic University of the Sacred Heart School of Medicine, Rome, ItalyDepartment of Gastroenterology, Pancreatic Unit, Catholic University of the Sacred Heart School of Medicine, Rome, ItalyDepartment of Gastroenterology, Pancreatic Unit, Catholic University of the Sacred Heart School of Medicine, Rome, ItalyDepartment of Internal Medicine, Catholic University of the Sacred Heart School of Medicine, Rome, ItalyGut microbiota is key to the development and modulation of the mucosal immune system. It plays a central role in several physiological functions, in the modulation of inflammatory signaling and in the protection against infections. In healthy states, there is a perfect balance between commensal and pathogens, and microbiota and the immune system interact to maintain gut homeostasis. The alteration of such balance, called dysbiosis, determines an intestinal bacterial overgrowth which leads to the disruption of the intestinal barrier with systemic translocation of pathogens. The pancreas does not possess its own microbiota, and it is believed that inflammatory and neoplastic processes affecting the gland may be linked to intestinal dysbiosis. Increasing research evidence testifies a correlation between intestinal dysbiosis and various pancreatic disorders, but it remains unclear whether dysbiosis is the cause or an effect. The analysis of specific alterations in the microbiome profile may permit to develop novel tools for the early detection of several pancreatic disorders, utilizing samples, such as blood, saliva, and stools. Future studies will have to elucidate the mechanisms by which gut microbiota is modulated and how it tunes the immune system, in order to be able to develop innovative treatment strategies for pancreatic disorders.http://dx.doi.org/10.1155/2018/7946431 |
| spellingShingle | D. Pagliari A. Saviano E. E. Newton M. L. Serricchio A. A. Dal Lago A. Gasbarrini R. Cianci Gut Microbiota-Immune System Crosstalk and Pancreatic Disorders Mediators of Inflammation |
| title | Gut Microbiota-Immune System Crosstalk and Pancreatic Disorders |
| title_full | Gut Microbiota-Immune System Crosstalk and Pancreatic Disorders |
| title_fullStr | Gut Microbiota-Immune System Crosstalk and Pancreatic Disorders |
| title_full_unstemmed | Gut Microbiota-Immune System Crosstalk and Pancreatic Disorders |
| title_short | Gut Microbiota-Immune System Crosstalk and Pancreatic Disorders |
| title_sort | gut microbiota immune system crosstalk and pancreatic disorders |
| url | http://dx.doi.org/10.1155/2018/7946431 |
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