Contribution of Regulatory T Cell Methylation Modifications to the Pathogenesis of Allergic Airway Diseases
Regulatory T (Treg) cells are a subtype of CD4+ T cells that play a significant role in the protection from autoimmunity and the maintenance of immune tolerance via immune regulation. Epigenetic modifications of Treg cells (i.e., cytosine methylation at the promoter region of the transcription facto...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/5590217 |
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| author | Jiani Li Jichao Sha Liwei Sun Dongdong Zhu Cuida Meng |
| author_facet | Jiani Li Jichao Sha Liwei Sun Dongdong Zhu Cuida Meng |
| author_sort | Jiani Li |
| collection | DOAJ |
| description | Regulatory T (Treg) cells are a subtype of CD4+ T cells that play a significant role in the protection from autoimmunity and the maintenance of immune tolerance via immune regulation. Epigenetic modifications of Treg cells (i.e., cytosine methylation at the promoter region of the transcription factor, Forkhead Box P3) have been found to be closely associated with allergic diseases, including allergic rhinitis, asthma, and food allergies. In this study, we highlighted the recent evidence on the contribution of epigenetic modifications in Treg cells to the pathogenesis of allergic diseases. Moreover, we also discussed directions for future clinical treatment approaches, with a particular emphasis on Treg cell-targeted therapies for allergic disorders. |
| format | Article |
| id | doaj-art-0e58e5306fe9404ea7eef40f62e2893a |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-0e58e5306fe9404ea7eef40f62e2893a2025-02-03T05:44:08ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/55902175590217Contribution of Regulatory T Cell Methylation Modifications to the Pathogenesis of Allergic Airway DiseasesJiani Li0Jichao Sha1Liwei Sun2Dongdong Zhu3Cuida Meng4Department of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, ChinaRegulatory T (Treg) cells are a subtype of CD4+ T cells that play a significant role in the protection from autoimmunity and the maintenance of immune tolerance via immune regulation. Epigenetic modifications of Treg cells (i.e., cytosine methylation at the promoter region of the transcription factor, Forkhead Box P3) have been found to be closely associated with allergic diseases, including allergic rhinitis, asthma, and food allergies. In this study, we highlighted the recent evidence on the contribution of epigenetic modifications in Treg cells to the pathogenesis of allergic diseases. Moreover, we also discussed directions for future clinical treatment approaches, with a particular emphasis on Treg cell-targeted therapies for allergic disorders.http://dx.doi.org/10.1155/2021/5590217 |
| spellingShingle | Jiani Li Jichao Sha Liwei Sun Dongdong Zhu Cuida Meng Contribution of Regulatory T Cell Methylation Modifications to the Pathogenesis of Allergic Airway Diseases Journal of Immunology Research |
| title | Contribution of Regulatory T Cell Methylation Modifications to the Pathogenesis of Allergic Airway Diseases |
| title_full | Contribution of Regulatory T Cell Methylation Modifications to the Pathogenesis of Allergic Airway Diseases |
| title_fullStr | Contribution of Regulatory T Cell Methylation Modifications to the Pathogenesis of Allergic Airway Diseases |
| title_full_unstemmed | Contribution of Regulatory T Cell Methylation Modifications to the Pathogenesis of Allergic Airway Diseases |
| title_short | Contribution of Regulatory T Cell Methylation Modifications to the Pathogenesis of Allergic Airway Diseases |
| title_sort | contribution of regulatory t cell methylation modifications to the pathogenesis of allergic airway diseases |
| url | http://dx.doi.org/10.1155/2021/5590217 |
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