Atypical Celiac Disease: From Recognizing to Managing
The nonclassic clinical presentation of celiac disease (CD) becomes increasingly common in physician’s daily practice, which requires an awareness of its many clinical faces with atypical, silent, and latent forms. Besides the common genetic background (HLA DQ2/DQ8) of the disease, other non-HLA gen...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/637187 |
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| author | B. Admou L. Essaadouni K. Krati K. Zaher M. Sbihi L. Chabaa B. Belaabidia A. Alaoui-Yazidi |
| author_facet | B. Admou L. Essaadouni K. Krati K. Zaher M. Sbihi L. Chabaa B. Belaabidia A. Alaoui-Yazidi |
| author_sort | B. Admou |
| collection | DOAJ |
| description | The nonclassic clinical presentation of celiac disease (CD) becomes increasingly common in physician’s daily practice, which requires an awareness of its many clinical faces with atypical, silent, and latent forms. Besides the common genetic background (HLA DQ2/DQ8) of the disease, other non-HLA genes are now notably reported with a probable association to atypical forms. The availability of high-sensitive and specific serologic tests such as antitissue transglutuminase, antiendomysium, and more recent antideamidated, gliadin peptide antibodies permits to efficiently uncover a large portion of the submerged CD iceberg, including individuals having conditions associated with a high risk of developing CD (type 1 diabetes, autoimmune diseases, Down syndrome, family history of CD, etc.), biologic abnormalities (iron deficiency anemia, abnormal transaminase levels, etc.), and extraintestinal symptoms (short stature, neuropsychiatric disorders, alopecia, dental enamel hypoplasia, recurrent aphtous stomatitis, etc.). Despite the therapeutic alternatives currently in developing, the strict adherence to a GFD remains the only effective and safe therapy for CD. |
| format | Article |
| id | doaj-art-0e4c851400214859bd67092f6291977a |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-0e4c851400214859bd67092f6291977a2025-02-03T06:44:16ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/637187637187Atypical Celiac Disease: From Recognizing to ManagingB. Admou0L. Essaadouni1K. Krati2K. Zaher3M. Sbihi4L. Chabaa5B. Belaabidia6A. Alaoui-Yazidi7Laboratory of Immunology, Faculty of Medicine and University Hospital Center, BP 7010, Sidi Abbad, Marrakech, MoroccoService of Internal Medicine, University Hospital Center, Marrakech, MoroccoService of Gastroenterology, University Hospital Center, Marrakech, MoroccoLaboratory of Research “PCIM”, Faculty of Medicine, University Cadi Ayyad, Marrakech, MoroccoService of Peadiatrics, University Hospital Center, Marrakech, MoroccoLaboratory of Biochemistry, University Hospital Center, Marrakech, MoroccoLaboratory of Histopathology, University Hospital Center, Marrakech, MoroccoLaboratory of Research “PCIM”, Faculty of Medicine, University Cadi Ayyad, Marrakech, MoroccoThe nonclassic clinical presentation of celiac disease (CD) becomes increasingly common in physician’s daily practice, which requires an awareness of its many clinical faces with atypical, silent, and latent forms. Besides the common genetic background (HLA DQ2/DQ8) of the disease, other non-HLA genes are now notably reported with a probable association to atypical forms. The availability of high-sensitive and specific serologic tests such as antitissue transglutuminase, antiendomysium, and more recent antideamidated, gliadin peptide antibodies permits to efficiently uncover a large portion of the submerged CD iceberg, including individuals having conditions associated with a high risk of developing CD (type 1 diabetes, autoimmune diseases, Down syndrome, family history of CD, etc.), biologic abnormalities (iron deficiency anemia, abnormal transaminase levels, etc.), and extraintestinal symptoms (short stature, neuropsychiatric disorders, alopecia, dental enamel hypoplasia, recurrent aphtous stomatitis, etc.). Despite the therapeutic alternatives currently in developing, the strict adherence to a GFD remains the only effective and safe therapy for CD.http://dx.doi.org/10.1155/2012/637187 |
| spellingShingle | B. Admou L. Essaadouni K. Krati K. Zaher M. Sbihi L. Chabaa B. Belaabidia A. Alaoui-Yazidi Atypical Celiac Disease: From Recognizing to Managing Gastroenterology Research and Practice |
| title | Atypical Celiac Disease: From Recognizing to Managing |
| title_full | Atypical Celiac Disease: From Recognizing to Managing |
| title_fullStr | Atypical Celiac Disease: From Recognizing to Managing |
| title_full_unstemmed | Atypical Celiac Disease: From Recognizing to Managing |
| title_short | Atypical Celiac Disease: From Recognizing to Managing |
| title_sort | atypical celiac disease from recognizing to managing |
| url | http://dx.doi.org/10.1155/2012/637187 |
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