Experimental and computational insights into the therapeutic mechanisms of resveratrol in a Drosophila α-synuclein model of Parkinson’s disease

Experimental and computational insights into the therapeutic mechanisms of resveratrol in a Drosophila α-synuclein model of Parkinson’s disease

Abstract Parkinson’s disease (PD) is a multifactorial neurodegenerative disorder driven by genetic predisposition and environmental exposure. Given its well-documented antioxidative and neuroprotective properties, resveratrol is increasingly being considered for its potential to counteract the neuro...

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Bibliographic Details
Main Authors: Amos Olalekan Abolaji, Adeola Oluwatosin Adedara, Judith Chizoba Madu, Oluwabunmi Tomilola Owalude, Oludare Michael Ogunyemi, Damilola A. Omoboyowa, Folorunsho Bright Omage, Alexander J. Whitworth, Michael Aschner
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
α-synuclein
Antioxidant
Parkinson’s disease
Resveratrol
Network pharmacology
Molecular docking
Online Access:https://doi.org/10.1038/s41598-025-00698-9
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