The Estonian Biobank’s journey from biobanking to personalized medicine
Abstract Large biobanks have set a new standard for research and innovation in human genomics and implementation of personalized medicine. The Estonian Biobank was founded a quarter of a century ago, and its biological specimens, clinical, health, omics, and lifestyle data have been included in over...
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Nature Portfolio
2025-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-58465-3 |
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| author | Lili Milani Maris Alver Sven Laur Sulev Reisberg Toomas Haller Oliver Aasmets Erik Abner Helene Alavere Annely Allik Tarmo Annilo Krista Fischer Robin Hofmeister Georgi Hudjashov Maarja Jõeloo Mart Kals Liis Karo-Astover Silva Kasela Anastassia Kolde Kristi Krebs Kertu Liis Krigul Jaanika Kronberg Karoliina Kruusmaa Viktorija Kukuškina Kadri Kõiv Kelli Lehto Liis Leitsalu Sirje Lind Laura Birgit Luitva Kristi Läll Kreete Lüll Kristjan Metsalu Mait Metspalu René Mõttus Mari Nelis Tiit Nikopensius Miriam Nurm Margit Nõukas Marek Oja Elin Org Marili Palover Priit Palta Vasili Pankratov Kateryna Pantiukh Natalia Pervjakova Natàlia Pujol-Gualdo Anu Reigo Ene Reimann Steven Smit Diana Rogozina Dage Särg Nele Taba Harry-Anton Talvik Maris Teder-Laving Neeme Tõnisson Mariliis Vaht Uku Vainik Urmo Võsa Burak Yelmen Tõnu Esko Raivo Kolde Reedik Mägi Jaak Vilo Triin Laisk Andres Metspalu |
| author_facet | Lili Milani Maris Alver Sven Laur Sulev Reisberg Toomas Haller Oliver Aasmets Erik Abner Helene Alavere Annely Allik Tarmo Annilo Krista Fischer Robin Hofmeister Georgi Hudjashov Maarja Jõeloo Mart Kals Liis Karo-Astover Silva Kasela Anastassia Kolde Kristi Krebs Kertu Liis Krigul Jaanika Kronberg Karoliina Kruusmaa Viktorija Kukuškina Kadri Kõiv Kelli Lehto Liis Leitsalu Sirje Lind Laura Birgit Luitva Kristi Läll Kreete Lüll Kristjan Metsalu Mait Metspalu René Mõttus Mari Nelis Tiit Nikopensius Miriam Nurm Margit Nõukas Marek Oja Elin Org Marili Palover Priit Palta Vasili Pankratov Kateryna Pantiukh Natalia Pervjakova Natàlia Pujol-Gualdo Anu Reigo Ene Reimann Steven Smit Diana Rogozina Dage Särg Nele Taba Harry-Anton Talvik Maris Teder-Laving Neeme Tõnisson Mariliis Vaht Uku Vainik Urmo Võsa Burak Yelmen Tõnu Esko Raivo Kolde Reedik Mägi Jaak Vilo Triin Laisk Andres Metspalu |
| author_sort | Lili Milani |
| collection | DOAJ |
| description | Abstract Large biobanks have set a new standard for research and innovation in human genomics and implementation of personalized medicine. The Estonian Biobank was founded a quarter of a century ago, and its biological specimens, clinical, health, omics, and lifestyle data have been included in over 800 publications to date. What makes the biobank unique internationally is its translational focus, with active efforts to conduct clinical studies based on genetic findings, and to explore the effects of return of results on participants. In this review, we provide an overview of the Estonian Biobank, highlight its strengths for studying the effects of genetic variation and quantitative phenotypes on health-related traits, development of methods and frameworks for bringing genomics into the clinic, and its role as a driving force for implementing personalized medicine on a national level and beyond. |
| format | Article |
| id | doaj-art-0e497bbfd7f146d584f1ac321ebeea5f |
| institution | DOAJ |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-0e497bbfd7f146d584f1ac321ebeea5f2025-08-20T03:04:51ZengNature PortfolioNature Communications2041-17232025-04-0116111310.1038/s41467-025-58465-3The Estonian Biobank’s journey from biobanking to personalized medicineLili Milani0Maris Alver1Sven Laur2Sulev Reisberg3Toomas Haller4Oliver Aasmets5Erik Abner6Helene Alavere7Annely Allik8Tarmo Annilo9Krista Fischer10Robin Hofmeister11Georgi Hudjashov12Maarja Jõeloo13Mart Kals14Liis Karo-Astover15Silva Kasela16Anastassia Kolde17Kristi Krebs18Kertu Liis Krigul19Jaanika Kronberg20Karoliina Kruusmaa21Viktorija Kukuškina22Kadri Kõiv23Kelli Lehto24Liis Leitsalu25Sirje Lind26Laura Birgit Luitva27Kristi Läll28Kreete Lüll29Kristjan Metsalu30Mait Metspalu31René Mõttus32Mari Nelis33Tiit Nikopensius34Miriam Nurm35Margit Nõukas36Marek Oja37Elin Org38Marili Palover39Priit Palta40Vasili Pankratov41Kateryna Pantiukh42Natalia Pervjakova43Natàlia Pujol-Gualdo44Anu Reigo45Ene Reimann46Steven Smit47Diana Rogozina48Dage Särg49Nele Taba50Harry-Anton Talvik51Maris Teder-Laving52Neeme Tõnisson53Mariliis Vaht54Uku Vainik55Urmo Võsa56Burak Yelmen57Tõnu Esko58Raivo Kolde59Reedik Mägi60Jaak Vilo61Triin Laisk62Andres Metspalu63Estonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuInstitute of Computer Science, University of TartuInstitute of Computer Science, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Biobank, Institute of Genomics, University of TartuEstonian Biobank, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Biobank, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Biobank, Institute of Genomics, University of TartuEstonian Biocentre, Institute of Genomics, University of TartuInstitute of Psychology, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuInstitute of Computer Science, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuCentre for Genomics, Evolution and Medicine, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Biobank, Institute of Genomics, University of TartuEstonian Biobank, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuInstitute of Computer Science, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuInstitute of Computer Science, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuInstitute of Computer Science, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuEstonian Genome Centre, Institute of Genomics, University of TartuAbstract Large biobanks have set a new standard for research and innovation in human genomics and implementation of personalized medicine. The Estonian Biobank was founded a quarter of a century ago, and its biological specimens, clinical, health, omics, and lifestyle data have been included in over 800 publications to date. What makes the biobank unique internationally is its translational focus, with active efforts to conduct clinical studies based on genetic findings, and to explore the effects of return of results on participants. In this review, we provide an overview of the Estonian Biobank, highlight its strengths for studying the effects of genetic variation and quantitative phenotypes on health-related traits, development of methods and frameworks for bringing genomics into the clinic, and its role as a driving force for implementing personalized medicine on a national level and beyond.https://doi.org/10.1038/s41467-025-58465-3 |
| spellingShingle | Lili Milani Maris Alver Sven Laur Sulev Reisberg Toomas Haller Oliver Aasmets Erik Abner Helene Alavere Annely Allik Tarmo Annilo Krista Fischer Robin Hofmeister Georgi Hudjashov Maarja Jõeloo Mart Kals Liis Karo-Astover Silva Kasela Anastassia Kolde Kristi Krebs Kertu Liis Krigul Jaanika Kronberg Karoliina Kruusmaa Viktorija Kukuškina Kadri Kõiv Kelli Lehto Liis Leitsalu Sirje Lind Laura Birgit Luitva Kristi Läll Kreete Lüll Kristjan Metsalu Mait Metspalu René Mõttus Mari Nelis Tiit Nikopensius Miriam Nurm Margit Nõukas Marek Oja Elin Org Marili Palover Priit Palta Vasili Pankratov Kateryna Pantiukh Natalia Pervjakova Natàlia Pujol-Gualdo Anu Reigo Ene Reimann Steven Smit Diana Rogozina Dage Särg Nele Taba Harry-Anton Talvik Maris Teder-Laving Neeme Tõnisson Mariliis Vaht Uku Vainik Urmo Võsa Burak Yelmen Tõnu Esko Raivo Kolde Reedik Mägi Jaak Vilo Triin Laisk Andres Metspalu The Estonian Biobank’s journey from biobanking to personalized medicine Nature Communications |
| title | The Estonian Biobank’s journey from biobanking to personalized medicine |
| title_full | The Estonian Biobank’s journey from biobanking to personalized medicine |
| title_fullStr | The Estonian Biobank’s journey from biobanking to personalized medicine |
| title_full_unstemmed | The Estonian Biobank’s journey from biobanking to personalized medicine |
| title_short | The Estonian Biobank’s journey from biobanking to personalized medicine |
| title_sort | estonian biobank s journey from biobanking to personalized medicine |
| url | https://doi.org/10.1038/s41467-025-58465-3 |
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