Epidermal Stem Cells in Wound Healing and Regeneration
Skin stem cells distributed in the basal layer of the epidermis and hair follicles are important cell sources for skin development, metabolism, and injury repair. At present, great progress has been made in the study of epidermal stem cells at the cellular and molecular levels. Stem cell transplanta...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2020/9148310 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565835557765120 |
|---|---|
| author | Ronghua Yang Jingru Wang Xiaodong Chen Yan Shi Julin Xie |
| author_facet | Ronghua Yang Jingru Wang Xiaodong Chen Yan Shi Julin Xie |
| author_sort | Ronghua Yang |
| collection | DOAJ |
| description | Skin stem cells distributed in the basal layer of the epidermis and hair follicles are important cell sources for skin development, metabolism, and injury repair. At present, great progress has been made in the study of epidermal stem cells at the cellular and molecular levels. Stem cell transplantation is reported to promote skin healing, endothelial cell transformation, and vascular formation. Local stem cells can also be transformed into keratinocytes, sebaceous gland, and other skin-associated tissues. However, the mechanism of action of epidermal stem cells on wound healing and regeneration is not completely clear. This review is aimed at briefly summarizing the biological characteristics of epidermal stem cells and their clinical application in wound healing and tissue regeneration. It further discussed the mechanism of action and the development direction in the future. |
| format | Article |
| id | doaj-art-0e3de004565648cdba3bea0e7532d143 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-0e3de004565648cdba3bea0e7532d1432025-02-03T01:06:18ZengWileyStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/91483109148310Epidermal Stem Cells in Wound Healing and RegenerationRonghua Yang0Jingru Wang1Xiaodong Chen2Yan Shi3Julin Xie4Department of Burn Surgery, The First People’s Hospital of Foshan, Foshan 528000, ChinaDepartment of Burn Surgery, The First People’s Hospital of Foshan, Foshan 528000, ChinaDepartment of Burn Surgery, The First People’s Hospital of Foshan, Foshan 528000, ChinaDepartment of Medical Cosmetology, Jiangxi Maternal and Child Health Hospital, Nanchang 330006, ChinaDepartment of Burn Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 512100, ChinaSkin stem cells distributed in the basal layer of the epidermis and hair follicles are important cell sources for skin development, metabolism, and injury repair. At present, great progress has been made in the study of epidermal stem cells at the cellular and molecular levels. Stem cell transplantation is reported to promote skin healing, endothelial cell transformation, and vascular formation. Local stem cells can also be transformed into keratinocytes, sebaceous gland, and other skin-associated tissues. However, the mechanism of action of epidermal stem cells on wound healing and regeneration is not completely clear. This review is aimed at briefly summarizing the biological characteristics of epidermal stem cells and their clinical application in wound healing and tissue regeneration. It further discussed the mechanism of action and the development direction in the future.http://dx.doi.org/10.1155/2020/9148310 |
| spellingShingle | Ronghua Yang Jingru Wang Xiaodong Chen Yan Shi Julin Xie Epidermal Stem Cells in Wound Healing and Regeneration Stem Cells International |
| title | Epidermal Stem Cells in Wound Healing and Regeneration |
| title_full | Epidermal Stem Cells in Wound Healing and Regeneration |
| title_fullStr | Epidermal Stem Cells in Wound Healing and Regeneration |
| title_full_unstemmed | Epidermal Stem Cells in Wound Healing and Regeneration |
| title_short | Epidermal Stem Cells in Wound Healing and Regeneration |
| title_sort | epidermal stem cells in wound healing and regeneration |
| url | http://dx.doi.org/10.1155/2020/9148310 |
| work_keys_str_mv | AT ronghuayang epidermalstemcellsinwoundhealingandregeneration AT jingruwang epidermalstemcellsinwoundhealingandregeneration AT xiaodongchen epidermalstemcellsinwoundhealingandregeneration AT yanshi epidermalstemcellsinwoundhealingandregeneration AT julinxie epidermalstemcellsinwoundhealingandregeneration |