Effector Caspases and Leukemia
Caspases, a family of aspartate-specific cysteine proteases, play a major role in apoptosis and a variety of physiological and pathological processes. Fourteen mammalian caspases have been identified and can be divided into two groups: inflammatory caspases and apoptotic caspases. Based on the struc...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2011/738301 |
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| _version_ | 1832550190308917248 |
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| author | Ying Lu Guo-Qiang Chen |
| author_facet | Ying Lu Guo-Qiang Chen |
| author_sort | Ying Lu |
| collection | DOAJ |
| description | Caspases, a family of aspartate-specific cysteine proteases, play a major role in apoptosis and a variety of physiological and pathological processes. Fourteen mammalian caspases have been identified and can be divided into two groups: inflammatory caspases and apoptotic caspases. Based on the structure and function, the apoptotic caspases are further grouped into initiator/apical caspases (caspase-2, -8, -9, and -10) and effector/executioner caspases (caspase-3, -6, and -7). In this paper, we discuss what we have learned about the role of individual effector caspase in mediating both apoptotic and nonapoptotic events, with special emphasis on leukemia-specific oncoproteins in relation to effector caspases. |
| format | Article |
| id | doaj-art-0e26ede0c53f4f8fa78d195346e5b377 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-0e26ede0c53f4f8fa78d195346e5b3772025-02-03T06:07:24ZengWileyInternational Journal of Cell Biology1687-88761687-88842011-01-01201110.1155/2011/738301738301Effector Caspases and LeukemiaYing Lu0Guo-Qiang Chen1Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaCaspases, a family of aspartate-specific cysteine proteases, play a major role in apoptosis and a variety of physiological and pathological processes. Fourteen mammalian caspases have been identified and can be divided into two groups: inflammatory caspases and apoptotic caspases. Based on the structure and function, the apoptotic caspases are further grouped into initiator/apical caspases (caspase-2, -8, -9, and -10) and effector/executioner caspases (caspase-3, -6, and -7). In this paper, we discuss what we have learned about the role of individual effector caspase in mediating both apoptotic and nonapoptotic events, with special emphasis on leukemia-specific oncoproteins in relation to effector caspases.http://dx.doi.org/10.1155/2011/738301 |
| spellingShingle | Ying Lu Guo-Qiang Chen Effector Caspases and Leukemia International Journal of Cell Biology |
| title | Effector Caspases and Leukemia |
| title_full | Effector Caspases and Leukemia |
| title_fullStr | Effector Caspases and Leukemia |
| title_full_unstemmed | Effector Caspases and Leukemia |
| title_short | Effector Caspases and Leukemia |
| title_sort | effector caspases and leukemia |
| url | http://dx.doi.org/10.1155/2011/738301 |
| work_keys_str_mv | AT yinglu effectorcaspasesandleukemia AT guoqiangchen effectorcaspasesandleukemia |