Desensitization of delayed-type hypersensitivity in mice: suppressive environment
The systemic injection of high doses of antigen into a preimmunized animal results in transient unresponsiveness of cell-mediated immune responses. This phenomenon is known as desensitization. Serum interleukin 2 (IL-2) activity was found transiently in desensitized mice at 3 h after the antigen cha...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1993-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935193000274 |
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| _version_ | 1832551512077762560 |
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| author | Takashi Katsura Kazuo Kobayashi Michio Hosaka Sachiko Sugihara Tsuyoshi Kasama Keita Kasahara Stanley Cohen Takeshi Yoshida |
| author_facet | Takashi Katsura Kazuo Kobayashi Michio Hosaka Sachiko Sugihara Tsuyoshi Kasama Keita Kasahara Stanley Cohen Takeshi Yoshida |
| author_sort | Takashi Katsura |
| collection | DOAJ |
| description | The systemic injection of high doses of antigen into a preimmunized animal results in transient unresponsiveness of cell-mediated immune responses. This phenomenon is known as desensitization. Serum interleukin 2 (IL-2) activity was found transiently in desensitized mice at 3 h after the antigen challenge. These mice could not reveal antigen nonspecific delayed-type hypersensitivity (DTH) 1 d after the challenge. Specific suppression of DTH was observed at later stages. Sera from 3 h desensitized mice showed suppressive effects on DTH in preo immunized mice. Administration of recombinant IL-2 into preimmunized mice led to the failure of development of DTH to antigens. These observations suggest that IL-2 plays an important role in the suppressive environment. |
| format | Article |
| id | doaj-art-0e16983490a849538aaf47989119d4a1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1993-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0e16983490a849538aaf47989119d4a12025-02-03T06:01:15ZengWileyMediators of Inflammation0962-93511466-18611993-01-012320521010.1155/S0962935193000274Desensitization of delayed-type hypersensitivity in mice: suppressive environmentTakashi Katsura0Kazuo Kobayashi1Michio Hosaka2Sachiko Sugihara3Tsuyoshi Kasama4Keita Kasahara5Stanley Cohen6Takeshi Yoshida7The First Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142, JapanThe First Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142, JapanThe First Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142, JapanThe First Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142, JapanThe First Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142, JapanThe First Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142, JapanDepartment of PathoLogy, Hahnemann University, Philadelphia, USATokyo Institute for Immunopharmacology, Tokyo, JapanThe systemic injection of high doses of antigen into a preimmunized animal results in transient unresponsiveness of cell-mediated immune responses. This phenomenon is known as desensitization. Serum interleukin 2 (IL-2) activity was found transiently in desensitized mice at 3 h after the antigen challenge. These mice could not reveal antigen nonspecific delayed-type hypersensitivity (DTH) 1 d after the challenge. Specific suppression of DTH was observed at later stages. Sera from 3 h desensitized mice showed suppressive effects on DTH in preo immunized mice. Administration of recombinant IL-2 into preimmunized mice led to the failure of development of DTH to antigens. These observations suggest that IL-2 plays an important role in the suppressive environment.http://dx.doi.org/10.1155/S0962935193000274 |
| spellingShingle | Takashi Katsura Kazuo Kobayashi Michio Hosaka Sachiko Sugihara Tsuyoshi Kasama Keita Kasahara Stanley Cohen Takeshi Yoshida Desensitization of delayed-type hypersensitivity in mice: suppressive environment Mediators of Inflammation |
| title | Desensitization of delayed-type hypersensitivity in mice: suppressive environment |
| title_full | Desensitization of delayed-type hypersensitivity in mice: suppressive environment |
| title_fullStr | Desensitization of delayed-type hypersensitivity in mice: suppressive environment |
| title_full_unstemmed | Desensitization of delayed-type hypersensitivity in mice: suppressive environment |
| title_short | Desensitization of delayed-type hypersensitivity in mice: suppressive environment |
| title_sort | desensitization of delayed type hypersensitivity in mice suppressive environment |
| url | http://dx.doi.org/10.1155/S0962935193000274 |
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