Comparison of Contemporary and Historic Highly Pathogenic Avian Influenza A(H5N1) Virus Replication in Human Lung Organoids

Comparison of Contemporary and Historic Highly Pathogenic Avian Influenza A(H5N1) Virus Replication in Human Lung Organoids

We compared virus replication and host responses in human alveolar epithelium infected with highly pathogenic avian influenza (HPAI) A(H5N1) viruses. A/Vietnam/1203/2004 replicated most efficiently, followed by A/Texas/37/2024, then A/bovine/Ohio/B24OSU-342/2024. Induction of interferon-stimulated...

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Bibliographic Details
Main Authors: Meaghan Flagg, Brandi N. Williamson, Johan A. Ortiz-Morales, Tessa R. Lutterman, Emmie de Wit
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2025-02-01
Series:Emerging Infectious Diseases
Subjects:
Influenza A virus
influenza
zoonoses
respiratory infections
viruses
highly pathogenic avian influenza
Online Access:https://wwwnc.cdc.gov/eid/article/31/2/24-1147_article
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