Comparison of Contemporary and Historic Highly Pathogenic Avian Influenza A(H5N1) Virus Replication in Human Lung Organoids
We compared virus replication and host responses in human alveolar epithelium infected with highly pathogenic avian influenza (HPAI) A(H5N1) viruses. A/Vietnam/1203/2004 replicated most efficiently, followed by A/Texas/37/2024, then A/bovine/Ohio/B24OSU-342/2024. Induction of interferon-stimulated...
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Centers for Disease Control and Prevention
2025-02-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/31/2/24-1147_article |
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| author | Meaghan Flagg Brandi N. Williamson Johan A. Ortiz-Morales Tessa R. Lutterman Emmie de Wit |
| author_facet | Meaghan Flagg Brandi N. Williamson Johan A. Ortiz-Morales Tessa R. Lutterman Emmie de Wit |
| author_sort | Meaghan Flagg |
| collection | DOAJ |
| description |
We compared virus replication and host responses in human alveolar epithelium infected with highly pathogenic avian influenza (HPAI) A(H5N1) viruses. A/Vietnam/1203/2004 replicated most efficiently, followed by A/Texas/37/2024, then A/bovine/Ohio/B24OSU-342/2024. Induction of interferon-stimulated genes was lower with A/Texas/37/2024 and A/bovine/Ohio/B24OSU-342/2024, which may indicate a reduced disease severity of those viruses.
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| format | Article |
| id | doaj-art-0e15f5d3ea5c4edb98f1fed4b41c6892 |
| institution | DOAJ |
| issn | 1080-6040 1080-6059 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj-art-0e15f5d3ea5c4edb98f1fed4b41c68922025-08-20T03:01:22ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592025-02-0131231832210.3201/eid3102.241147Comparison of Contemporary and Historic Highly Pathogenic Avian Influenza A(H5N1) Virus Replication in Human Lung OrganoidsMeaghan FlaggBrandi N. WilliamsonJohan A. Ortiz-MoralesTessa R. LuttermanEmmie de Wit We compared virus replication and host responses in human alveolar epithelium infected with highly pathogenic avian influenza (HPAI) A(H5N1) viruses. A/Vietnam/1203/2004 replicated most efficiently, followed by A/Texas/37/2024, then A/bovine/Ohio/B24OSU-342/2024. Induction of interferon-stimulated genes was lower with A/Texas/37/2024 and A/bovine/Ohio/B24OSU-342/2024, which may indicate a reduced disease severity of those viruses. https://wwwnc.cdc.gov/eid/article/31/2/24-1147_articleInfluenza A virusinfluenzazoonosesrespiratory infectionsviruseshighly pathogenic avian influenza |
| spellingShingle | Meaghan Flagg Brandi N. Williamson Johan A. Ortiz-Morales Tessa R. Lutterman Emmie de Wit Comparison of Contemporary and Historic Highly Pathogenic Avian Influenza A(H5N1) Virus Replication in Human Lung Organoids Emerging Infectious Diseases Influenza A virus influenza zoonoses respiratory infections viruses highly pathogenic avian influenza |
| title | Comparison of Contemporary and Historic Highly Pathogenic Avian Influenza A(H5N1) Virus Replication in Human Lung Organoids |
| title_full | Comparison of Contemporary and Historic Highly Pathogenic Avian Influenza A(H5N1) Virus Replication in Human Lung Organoids |
| title_fullStr | Comparison of Contemporary and Historic Highly Pathogenic Avian Influenza A(H5N1) Virus Replication in Human Lung Organoids |
| title_full_unstemmed | Comparison of Contemporary and Historic Highly Pathogenic Avian Influenza A(H5N1) Virus Replication in Human Lung Organoids |
| title_short | Comparison of Contemporary and Historic Highly Pathogenic Avian Influenza A(H5N1) Virus Replication in Human Lung Organoids |
| title_sort | comparison of contemporary and historic highly pathogenic avian influenza a h5n1 virus replication in human lung organoids |
| topic | Influenza A virus influenza zoonoses respiratory infections viruses highly pathogenic avian influenza |
| url | https://wwwnc.cdc.gov/eid/article/31/2/24-1147_article |
| work_keys_str_mv | AT meaghanflagg comparisonofcontemporaryandhistorichighlypathogenicavianinfluenzaah5n1virusreplicationinhumanlungorganoids AT brandinwilliamson comparisonofcontemporaryandhistorichighlypathogenicavianinfluenzaah5n1virusreplicationinhumanlungorganoids AT johanaortizmorales comparisonofcontemporaryandhistorichighlypathogenicavianinfluenzaah5n1virusreplicationinhumanlungorganoids AT tessarlutterman comparisonofcontemporaryandhistorichighlypathogenicavianinfluenzaah5n1virusreplicationinhumanlungorganoids AT emmiedewit comparisonofcontemporaryandhistorichighlypathogenicavianinfluenzaah5n1virusreplicationinhumanlungorganoids |