Novel Treatment of Small-Cell Neuroendocrine of the Vagina
Background. Primary vaginal small-cell neuroendocrine carcinoma is an extremely rare and highly aggressive malignancy. Eighty-five percent of patients die within one year of diagnosis from metastatic disease despite multimodal therapy. Gene expression profiling of tumor tissue may be useful for trea...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/9157036 |
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| _version_ | 1832562345801416704 |
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| author | Kathryn Kostamo Mishka Peart Nathalie McKenzie Conisha Holloman S. J. Carlan Li Ge John Maksem |
| author_facet | Kathryn Kostamo Mishka Peart Nathalie McKenzie Conisha Holloman S. J. Carlan Li Ge John Maksem |
| author_sort | Kathryn Kostamo |
| collection | DOAJ |
| description | Background. Primary vaginal small-cell neuroendocrine carcinoma is an extremely rare and highly aggressive malignancy. Eighty-five percent of patients die within one year of diagnosis from metastatic disease despite multimodal therapy. Gene expression profiling of tumor tissue may be useful for treatment options for various malignancies. Case. A 34-year-old nulliparous woman was diagnosed with primary vaginal small-cell neuroendocrine carcinoma. Twenty weeks after the initial visit, she was diagnosed with recurrence and started on chemoradiation based on the results of gene expression profile of tumor tissue. She died 34 months after the initial visit and had a 14-month progression-free survival (PFS). Conclusion. Gene expression profile of tumor tissue in the management of primary vaginal small-cell neuroendocrine carcinoma may be helpful in extending progression-free survival. |
| format | Article |
| id | doaj-art-0e0cff099fdf432c92e1102d27924836 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-0e0cff099fdf432c92e1102d279248362025-02-03T01:22:51ZengWileyCase Reports in Oncological Medicine2090-67062090-67142018-01-01201810.1155/2018/91570369157036Novel Treatment of Small-Cell Neuroendocrine of the VaginaKathryn Kostamo0Mishka Peart1Nathalie McKenzie2Conisha Holloman3S. J. Carlan4Li Ge5John Maksem6Department of Obstetrics and Gynecology, Orlando Regional Healthcare, Orlando, FL, USADepartment of Obstetrics and Gynecology, Orlando Regional Healthcare, Orlando, FL, USAGynecologic Oncology, Florida Hospital Medical Group, Maitland, FL, USADepartment of Obstetrics and Gynecology, Orlando Regional Healthcare, Orlando, FL, USADepartment of Obstetrics and Gynecology, Orlando Regional Healthcare, Orlando, FL, USADepartment of Pathology, Orlando Regional Healthcare, Orlando, FL, USADepartment of Pathology, Orlando Regional Healthcare, Orlando, FL, USABackground. Primary vaginal small-cell neuroendocrine carcinoma is an extremely rare and highly aggressive malignancy. Eighty-five percent of patients die within one year of diagnosis from metastatic disease despite multimodal therapy. Gene expression profiling of tumor tissue may be useful for treatment options for various malignancies. Case. A 34-year-old nulliparous woman was diagnosed with primary vaginal small-cell neuroendocrine carcinoma. Twenty weeks after the initial visit, she was diagnosed with recurrence and started on chemoradiation based on the results of gene expression profile of tumor tissue. She died 34 months after the initial visit and had a 14-month progression-free survival (PFS). Conclusion. Gene expression profile of tumor tissue in the management of primary vaginal small-cell neuroendocrine carcinoma may be helpful in extending progression-free survival.http://dx.doi.org/10.1155/2018/9157036 |
| spellingShingle | Kathryn Kostamo Mishka Peart Nathalie McKenzie Conisha Holloman S. J. Carlan Li Ge John Maksem Novel Treatment of Small-Cell Neuroendocrine of the Vagina Case Reports in Oncological Medicine |
| title | Novel Treatment of Small-Cell Neuroendocrine of the Vagina |
| title_full | Novel Treatment of Small-Cell Neuroendocrine of the Vagina |
| title_fullStr | Novel Treatment of Small-Cell Neuroendocrine of the Vagina |
| title_full_unstemmed | Novel Treatment of Small-Cell Neuroendocrine of the Vagina |
| title_short | Novel Treatment of Small-Cell Neuroendocrine of the Vagina |
| title_sort | novel treatment of small cell neuroendocrine of the vagina |
| url | http://dx.doi.org/10.1155/2018/9157036 |
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