Association between cardiopulmonary bypass duration and early major adverse cardiovascular events after surgical repair of supravalvular aortic stenosis
BackgroundPatients who underwent surgical repair of supravalvular aortic stenosis (SVAS) are at high risk for postoperative major adverse cardiovascular events (MACE). This study aimed to investigate the association between cardiopulmonary bypass (CPB) duration and MACE occurring during postoperativ...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1519251/full |
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| author | Simeng Zhang Caiyi Wei Bo Peng Lizhi Lv Fengbo Pei Jianming Xia Jun Yan Jie Liu Qiang Wang Yi Shi |
| author_facet | Simeng Zhang Caiyi Wei Bo Peng Lizhi Lv Fengbo Pei Jianming Xia Jun Yan Jie Liu Qiang Wang Yi Shi |
| author_sort | Simeng Zhang |
| collection | DOAJ |
| description | BackgroundPatients who underwent surgical repair of supravalvular aortic stenosis (SVAS) are at high risk for postoperative major adverse cardiovascular events (MACE). This study aimed to investigate the association between cardiopulmonary bypass (CPB) duration and MACE occurring during postoperative hospitalization or within 30 days post-surgery.MethodsPatients who underwent surgical repair of SVAS from 2002 to 2019 at Beijing Fuwai Hospital and Yunnan Fuwai Hospital were included in this study. Patients were stratified into “CPB duration >2 h” and “CPB duration ≤2 h” groups based on intraoperative CPB duration. Various statistical methodologies were employed to investigate the association between CPB duration and early postoperative MACE, including multivariate adjustment, propensity score adjustment, propensity score matching, and logistic regression based on propensity score weighting.Results297 participants were included and 164 were finally matched. In the propensity score-matched cohort, CPB duration was positively associated with early postoperative MACE (odds ratio = 18.13; 95% confidence interval 2.33–140.86; P = 0.006). Consistent results were obtained in the Inverse probability of treatment-weighted, standardized mortality ratio-weighted, pairwise algorithmic-weighted, and overlap-weighted models.ConclusionPatients with CPB duration >2 h were at a higher risk of early postoperative MACE compared to those with CPB duration ≤2 h. This emphasized the significance of minimizing CPB exposure for the prognosis of patients with SVAS. |
| format | Article |
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| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-0e0aa3601dd941cbbc3f2345ac20fb512025-01-21T08:36:58ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-01-011210.3389/fcvm.2025.15192511519251Association between cardiopulmonary bypass duration and early major adverse cardiovascular events after surgical repair of supravalvular aortic stenosisSimeng Zhang0Caiyi Wei1Bo Peng2Lizhi Lv3Fengbo Pei4Jianming Xia5Jun Yan6Jie Liu7Qiang Wang8Yi Shi9Department of Cardiac Surgery, Peking University People’s Hospital, Beijing, ChinaSchool of Basic Medical Sciences, Peking University, Beijing, ChinaDepartment of Cardiac Surgery, National Center for Cardiovascular Diseases and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaDepartment of Pediatric Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiac Surgery, Peking University People’s Hospital, Beijing, ChinaDepartment of Cardiac Surgery, Yunnan Fuwai Cardiovascular Hospital, Kunming, ChinaDepartment of Cardiac Surgery, National Center for Cardiovascular Diseases and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaDepartment of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing, ChinaDepartment of Pediatric Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiac Surgery, Peking University People’s Hospital, Beijing, ChinaBackgroundPatients who underwent surgical repair of supravalvular aortic stenosis (SVAS) are at high risk for postoperative major adverse cardiovascular events (MACE). This study aimed to investigate the association between cardiopulmonary bypass (CPB) duration and MACE occurring during postoperative hospitalization or within 30 days post-surgery.MethodsPatients who underwent surgical repair of SVAS from 2002 to 2019 at Beijing Fuwai Hospital and Yunnan Fuwai Hospital were included in this study. Patients were stratified into “CPB duration >2 h” and “CPB duration ≤2 h” groups based on intraoperative CPB duration. Various statistical methodologies were employed to investigate the association between CPB duration and early postoperative MACE, including multivariate adjustment, propensity score adjustment, propensity score matching, and logistic regression based on propensity score weighting.Results297 participants were included and 164 were finally matched. In the propensity score-matched cohort, CPB duration was positively associated with early postoperative MACE (odds ratio = 18.13; 95% confidence interval 2.33–140.86; P = 0.006). Consistent results were obtained in the Inverse probability of treatment-weighted, standardized mortality ratio-weighted, pairwise algorithmic-weighted, and overlap-weighted models.ConclusionPatients with CPB duration >2 h were at a higher risk of early postoperative MACE compared to those with CPB duration ≤2 h. This emphasized the significance of minimizing CPB exposure for the prognosis of patients with SVAS.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1519251/fullcardiopulmonary bypasssupravalvular aortic stenosisadverse cardiovascular eventssurgical therapylogistic regression analysis |
| spellingShingle | Simeng Zhang Caiyi Wei Bo Peng Lizhi Lv Fengbo Pei Jianming Xia Jun Yan Jie Liu Qiang Wang Yi Shi Association between cardiopulmonary bypass duration and early major adverse cardiovascular events after surgical repair of supravalvular aortic stenosis Frontiers in Cardiovascular Medicine cardiopulmonary bypass supravalvular aortic stenosis adverse cardiovascular events surgical therapy logistic regression analysis |
| title | Association between cardiopulmonary bypass duration and early major adverse cardiovascular events after surgical repair of supravalvular aortic stenosis |
| title_full | Association between cardiopulmonary bypass duration and early major adverse cardiovascular events after surgical repair of supravalvular aortic stenosis |
| title_fullStr | Association between cardiopulmonary bypass duration and early major adverse cardiovascular events after surgical repair of supravalvular aortic stenosis |
| title_full_unstemmed | Association between cardiopulmonary bypass duration and early major adverse cardiovascular events after surgical repair of supravalvular aortic stenosis |
| title_short | Association between cardiopulmonary bypass duration and early major adverse cardiovascular events after surgical repair of supravalvular aortic stenosis |
| title_sort | association between cardiopulmonary bypass duration and early major adverse cardiovascular events after surgical repair of supravalvular aortic stenosis |
| topic | cardiopulmonary bypass supravalvular aortic stenosis adverse cardiovascular events surgical therapy logistic regression analysis |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1519251/full |
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