In Vitro Antiproliferative Activity in Plants of the Genus <i>Tabebuia</i>: A Systematic Review
The use of plant extracts and the compounds isolated from them for the treatment of cancer is an area of active research, given their therapeutic potential. This work focused on evaluating the literature related to the antiproliferative activity of extracts obtained from plants of the genus <i>...
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MDPI AG
2025-05-01
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| author | Laura Mosquera-Morales Lina Marcela Orozco Luz Angela Veloza Juan Carlos Sepúlveda-Arias |
| author_facet | Laura Mosquera-Morales Lina Marcela Orozco Luz Angela Veloza Juan Carlos Sepúlveda-Arias |
| author_sort | Laura Mosquera-Morales |
| collection | DOAJ |
| description | The use of plant extracts and the compounds isolated from them for the treatment of cancer is an area of active research, given their therapeutic potential. This work focused on evaluating the literature related to the antiproliferative activity of extracts obtained from plants of the genus <i>Tabebuia</i> and molecules isolated in vitro or in vivo. For the search, MeSH and DECS terms were employed in the PubMed, Scopus, and SciELO databases. Research has shown that plant extracts derived from plants of the genus <i>Tabebuia</i> exhibit potential applications in the search for new molecules with antiproliferative activity. Among the isolated molecules, the most evaluated correspond to β-lapachone (naphthoquinone); however, molecules with antiproliferative potential belonging to groups such as iridoids, flavonoids, quinones, furanonaphthoquinones, triterpenes, and polysaccharides have also been isolated and reported. Additionally, synthesized molecules have been evaluated on the basis of the modifications made to the structures of molecules isolated from the plant extracts to increase their activity, aiming to develop more potent antitumor agents for future clinical use. |
| format | Article |
| id | doaj-art-0e0a4f3a1c72484f95fdd996fc46ec8c |
| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-0e0a4f3a1c72484f95fdd996fc46ec8c2025-08-20T02:23:00ZengMDPI AGMolecules1420-30492025-05-013011231510.3390/molecules30112315In Vitro Antiproliferative Activity in Plants of the Genus <i>Tabebuia</i>: A Systematic ReviewLaura Mosquera-Morales0Lina Marcela Orozco1Luz Angela Veloza2Juan Carlos Sepúlveda-Arias3Grupo Infección e Inmunidad, Facultad de Ciencias de la Salud, Universidad Tecnológica de Pereira, Pereira 660003, ColombiaGrupo Polifenoles, Facultad de Tecnologías, Escuela de Química, Universidad Tecnológica de Pereira, Pereira 660003, ColombiaGrupo Polifenoles, Facultad de Tecnologías, Escuela de Química, Universidad Tecnológica de Pereira, Pereira 660003, ColombiaGrupo Infección e Inmunidad, Facultad de Ciencias de la Salud, Universidad Tecnológica de Pereira, Pereira 660003, ColombiaThe use of plant extracts and the compounds isolated from them for the treatment of cancer is an area of active research, given their therapeutic potential. This work focused on evaluating the literature related to the antiproliferative activity of extracts obtained from plants of the genus <i>Tabebuia</i> and molecules isolated in vitro or in vivo. For the search, MeSH and DECS terms were employed in the PubMed, Scopus, and SciELO databases. Research has shown that plant extracts derived from plants of the genus <i>Tabebuia</i> exhibit potential applications in the search for new molecules with antiproliferative activity. Among the isolated molecules, the most evaluated correspond to β-lapachone (naphthoquinone); however, molecules with antiproliferative potential belonging to groups such as iridoids, flavonoids, quinones, furanonaphthoquinones, triterpenes, and polysaccharides have also been isolated and reported. Additionally, synthesized molecules have been evaluated on the basis of the modifications made to the structures of molecules isolated from the plant extracts to increase their activity, aiming to develop more potent antitumor agents for future clinical use.https://www.mdpi.com/1420-3049/30/11/2315<i>Tabebuia</i>cytotoxicityantiproliferativeapoptosisangiogenesiscancer |
| spellingShingle | Laura Mosquera-Morales Lina Marcela Orozco Luz Angela Veloza Juan Carlos Sepúlveda-Arias In Vitro Antiproliferative Activity in Plants of the Genus <i>Tabebuia</i>: A Systematic Review Molecules <i>Tabebuia</i> cytotoxicity antiproliferative apoptosis angiogenesis cancer |
| title | In Vitro Antiproliferative Activity in Plants of the Genus <i>Tabebuia</i>: A Systematic Review |
| title_full | In Vitro Antiproliferative Activity in Plants of the Genus <i>Tabebuia</i>: A Systematic Review |
| title_fullStr | In Vitro Antiproliferative Activity in Plants of the Genus <i>Tabebuia</i>: A Systematic Review |
| title_full_unstemmed | In Vitro Antiproliferative Activity in Plants of the Genus <i>Tabebuia</i>: A Systematic Review |
| title_short | In Vitro Antiproliferative Activity in Plants of the Genus <i>Tabebuia</i>: A Systematic Review |
| title_sort | in vitro antiproliferative activity in plants of the genus i tabebuia i a systematic review |
| topic | <i>Tabebuia</i> cytotoxicity antiproliferative apoptosis angiogenesis cancer |
| url | https://www.mdpi.com/1420-3049/30/11/2315 |
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