Association of abnormal vaginal microflora and HPV infection in cervical precancerous lesions: a retrospective study
Introduction: The aim of this study was to analyze the correlation between abnormal vaginal microflora and different types of human papillomavirus (HPV) infection and cervical precancerous lesions during the perimenopausal period. Methodology: This retrospective study included women patients who...
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The Journal of Infection in Developing Countries
2022-06-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/15961 |
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| author | Huan Yu Li Ma Meilu Bian Qian Li Haiyan Liang |
| author_facet | Huan Yu Li Ma Meilu Bian Qian Li Haiyan Liang |
| author_sort | Huan Yu |
| collection | DOAJ |
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Introduction: The aim of this study was to analyze the correlation between abnormal vaginal microflora and different types of human papillomavirus (HPV) infection and cervical precancerous lesions during the perimenopausal period.
Methodology: This retrospective study included women patients who underwent liquid-based cytologic test (LBC), HPV test, leucorrhea routine test, or routine urine test at the China-Japan Friendship Hospital between October 2019 and January 2020. A cut-off of 45 years was used as the cut-off age for menopause. The positivity and subtypes of HPV were determined using a chip-based assay. Vaginal microflora was determined using an HB-2012a flow-through hybridization instrument.
Results: A total of 132 patients were included in this study. 97 patients were younger than 45 years of age, with a median age of 35 (8.0), and 35 patients ≥ 45 years of age, with a median age of 55 (11.0). There were no significant differences in cytology, type of cervical lesion, HPV type, and common pathogens of the reproductive tract (all p > 0.05). The multivariable analysis showed that only HPV-16 infection lesions (OR: 2.825, 95% CI: 1.121-7.120, p = 0.028), Chlamydia trachomatis infection (OR: 0.142, 95% CI: 0.024-0.855, p =0.033), and Mycoplasma infection (OR: 7.750, 95% CI: 1.603-37.474, p = 0.011) were independent risk factors for cervical precancerous lesions. The menopausal status (with age < 45 or > 45 years as its surrogate) was not associated with cervical precancerous lesions.
Conclusions: Menopause was not associated with cervical precancerous lesions. The results suggest that the prevention and treatment of HPV-16, Chlamydia trachomatis infection, and Mycoplasma infection could be significant to prevent the occurrence of cervical precancerous lesions.
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| format | Article |
| id | doaj-art-0dea95d640a3473ba0653c9ffd7579e4 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | The Journal of Infection in Developing Countries |
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| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-0dea95d640a3473ba0653c9ffd7579e42025-08-20T02:16:06ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802022-06-01160610.3855/jidc.15961Association of abnormal vaginal microflora and HPV infection in cervical precancerous lesions: a retrospective studyHuan Yu0Li Ma1Meilu Bian2Qian Li3Haiyan Liang4Department of Obstetrics and Gynecology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Obstetrics and Gynecology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Obstetrics and Gynecology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Obstetrics and Gynecology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Obstetrics and Gynecology, China-Japan Friendship Hospital, Beijing, China Introduction: The aim of this study was to analyze the correlation between abnormal vaginal microflora and different types of human papillomavirus (HPV) infection and cervical precancerous lesions during the perimenopausal period. Methodology: This retrospective study included women patients who underwent liquid-based cytologic test (LBC), HPV test, leucorrhea routine test, or routine urine test at the China-Japan Friendship Hospital between October 2019 and January 2020. A cut-off of 45 years was used as the cut-off age for menopause. The positivity and subtypes of HPV were determined using a chip-based assay. Vaginal microflora was determined using an HB-2012a flow-through hybridization instrument. Results: A total of 132 patients were included in this study. 97 patients were younger than 45 years of age, with a median age of 35 (8.0), and 35 patients ≥ 45 years of age, with a median age of 55 (11.0). There were no significant differences in cytology, type of cervical lesion, HPV type, and common pathogens of the reproductive tract (all p > 0.05). The multivariable analysis showed that only HPV-16 infection lesions (OR: 2.825, 95% CI: 1.121-7.120, p = 0.028), Chlamydia trachomatis infection (OR: 0.142, 95% CI: 0.024-0.855, p =0.033), and Mycoplasma infection (OR: 7.750, 95% CI: 1.603-37.474, p = 0.011) were independent risk factors for cervical precancerous lesions. The menopausal status (with age < 45 or > 45 years as its surrogate) was not associated with cervical precancerous lesions. Conclusions: Menopause was not associated with cervical precancerous lesions. The results suggest that the prevention and treatment of HPV-16, Chlamydia trachomatis infection, and Mycoplasma infection could be significant to prevent the occurrence of cervical precancerous lesions. https://jidc.org/index.php/journal/article/view/15961Vaginal microflorahuman papillomaviruscervical cancerrisk factors |
| spellingShingle | Huan Yu Li Ma Meilu Bian Qian Li Haiyan Liang Association of abnormal vaginal microflora and HPV infection in cervical precancerous lesions: a retrospective study Journal of Infection in Developing Countries Vaginal microflora human papillomavirus cervical cancer risk factors |
| title | Association of abnormal vaginal microflora and HPV infection in cervical precancerous lesions: a retrospective study |
| title_full | Association of abnormal vaginal microflora and HPV infection in cervical precancerous lesions: a retrospective study |
| title_fullStr | Association of abnormal vaginal microflora and HPV infection in cervical precancerous lesions: a retrospective study |
| title_full_unstemmed | Association of abnormal vaginal microflora and HPV infection in cervical precancerous lesions: a retrospective study |
| title_short | Association of abnormal vaginal microflora and HPV infection in cervical precancerous lesions: a retrospective study |
| title_sort | association of abnormal vaginal microflora and hpv infection in cervical precancerous lesions a retrospective study |
| topic | Vaginal microflora human papillomavirus cervical cancer risk factors |
| url | https://jidc.org/index.php/journal/article/view/15961 |
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