Purinergic Receptors in Ocular Inflammation
Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly “tuned,” can lead to disease. When inflammation affects the eye, it can produce severe disorders affecting the superficial and internal parts of the visual organ. The nucleo...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/320906 |
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| author | Ana Guzman-Aranguez Xavier Gasull Yolanda Diebold Jesús Pintor |
| author_facet | Ana Guzman-Aranguez Xavier Gasull Yolanda Diebold Jesús Pintor |
| author_sort | Ana Guzman-Aranguez |
| collection | DOAJ |
| description | Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly “tuned,” can lead to disease. When inflammation affects the eye, it can produce severe disorders affecting the superficial and internal parts of the visual organ. The nucleoside adenosine and nucleotides including adenine mononucleotides like ADP and ATP and dinucleotides such as P1,P4-diadenosine tetraphosphate (Ap4A), and P1,P5-diadenosine pentaphosphate (Ap5A) are present in different ocular locations and therefore they may contribute/modulate inflammatory processes. Adenosine receptors, in particular A2A adenosine receptors, present anti-inflammatory action in acute and chronic retinal inflammation. Regarding the A3 receptor, selective agonists like N6-(3-iodobenzyl)-5′-N-methylcarboxamidoadenosine (CF101) have been used for the treatment of inflammatory ophthalmic diseases such as dry eye and uveoretinitis. Sideways, diverse stimuli (sensory stimulation, large intraocular pressure increases) can produce a release of ATP from ocular sensory innervation or after injury to ocular tissues. Then, ATP will activate purinergic P2 receptors present in sensory nerve endings, the iris, the ciliary body, or other tissues surrounding the anterior chamber of the eye to produce uveitis/endophthalmitis. In summary, adenosine and nucleotides can activate receptors in ocular structures susceptible to suffer from inflammatory processes. This involvement suggests the possible use of purinergic agonists and antagonists as therapeutic targets for ocular inflammation. |
| format | Article |
| id | doaj-art-0de1b8ae33d649f1a8859a35352a65f2 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0de1b8ae33d649f1a8859a35352a65f22025-02-03T06:14:17ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/320906320906Purinergic Receptors in Ocular InflammationAna Guzman-Aranguez0Xavier Gasull1Yolanda Diebold2Jesús Pintor3Department of Biochemistry and Molecular Biology IV, Faculty of Optics and Optometry, Universidad Complutense de Madrid, C/Arcos de Jalón 118, 28037 Madrid, SpainSpanish Cooperative Thematic Research Network in Ocular Prevalent and Chronic Pathology (RETIC), Instituto de Salud Carlos III, Madrid, SpainOcular Surface Group, Institute for Applied Ophthalmobiology (IOBA), University of Valladolid, Valladolid, SpainDepartment of Biochemistry and Molecular Biology IV, Faculty of Optics and Optometry, Universidad Complutense de Madrid, C/Arcos de Jalón 118, 28037 Madrid, SpainInflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly “tuned,” can lead to disease. When inflammation affects the eye, it can produce severe disorders affecting the superficial and internal parts of the visual organ. The nucleoside adenosine and nucleotides including adenine mononucleotides like ADP and ATP and dinucleotides such as P1,P4-diadenosine tetraphosphate (Ap4A), and P1,P5-diadenosine pentaphosphate (Ap5A) are present in different ocular locations and therefore they may contribute/modulate inflammatory processes. Adenosine receptors, in particular A2A adenosine receptors, present anti-inflammatory action in acute and chronic retinal inflammation. Regarding the A3 receptor, selective agonists like N6-(3-iodobenzyl)-5′-N-methylcarboxamidoadenosine (CF101) have been used for the treatment of inflammatory ophthalmic diseases such as dry eye and uveoretinitis. Sideways, diverse stimuli (sensory stimulation, large intraocular pressure increases) can produce a release of ATP from ocular sensory innervation or after injury to ocular tissues. Then, ATP will activate purinergic P2 receptors present in sensory nerve endings, the iris, the ciliary body, or other tissues surrounding the anterior chamber of the eye to produce uveitis/endophthalmitis. In summary, adenosine and nucleotides can activate receptors in ocular structures susceptible to suffer from inflammatory processes. This involvement suggests the possible use of purinergic agonists and antagonists as therapeutic targets for ocular inflammation.http://dx.doi.org/10.1155/2014/320906 |
| spellingShingle | Ana Guzman-Aranguez Xavier Gasull Yolanda Diebold Jesús Pintor Purinergic Receptors in Ocular Inflammation Mediators of Inflammation |
| title | Purinergic Receptors in Ocular Inflammation |
| title_full | Purinergic Receptors in Ocular Inflammation |
| title_fullStr | Purinergic Receptors in Ocular Inflammation |
| title_full_unstemmed | Purinergic Receptors in Ocular Inflammation |
| title_short | Purinergic Receptors in Ocular Inflammation |
| title_sort | purinergic receptors in ocular inflammation |
| url | http://dx.doi.org/10.1155/2014/320906 |
| work_keys_str_mv | AT anaguzmanaranguez purinergicreceptorsinocularinflammation AT xaviergasull purinergicreceptorsinocularinflammation AT yolandadiebold purinergicreceptorsinocularinflammation AT jesuspintor purinergicreceptorsinocularinflammation |