Cataract‐Causing Mutant R188C of βB2 Crystallin With Low Structural Stability is Sensitive to Environmental Stresses and Prone to Aggregates Formation

Cataract‐Causing Mutant R188C of βB2 Crystallin With Low Structural Stability is Sensitive to Environmental Stresses and Prone to Aggregates Formation

ABSTRACT This study investigated a Chinese family with congenital posterior polar cataracts linked to the βB2‐R188C mutation. βB2‐crystallin, a key structural component of the lens, is crucial for maintaining lens transparency and stability. We examined the effects of the R188C mutation on βB2‐cryst...

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Bibliographic Details
Main Authors: Yibo Yu, Silong Chen, Ying Zhang, Hang Song, Jiarui Guo, Chengpeng Wu, Wei Wu, Jingjie Xu, Xiaoyu Cheng, Chenqi Luo, Jing Guo, Yip Chee Chew, Ke Yao, Xiangjun Chen, Lidan Hu
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Exploration
Subjects:
aggregates
cataract
structural stability
Online Access:https://doi.org/10.1002/EXP.20240192
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https://doi.org/10.1002/EXP.20240192

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