Molecular Mechanisms in Exercise-Induced Cardioprotection
Physical inactivity is increasingly recognized as modifiable behavioral risk factor for cardiovascular diseases. A partial list of proposed mechanisms for exercise-induced cardioprotection include induction of heat shock proteins, increase in cardiac antioxidant capacity, expression of endoplasmic r...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.4061/2011/972807 |
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| _version_ | 1832547266178580480 |
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| author | Saeid Golbidi Ismail Laher |
| author_facet | Saeid Golbidi Ismail Laher |
| author_sort | Saeid Golbidi |
| collection | DOAJ |
| description | Physical inactivity is increasingly recognized as modifiable behavioral risk factor for cardiovascular diseases. A partial list of proposed mechanisms for exercise-induced cardioprotection include induction of heat shock proteins, increase in cardiac antioxidant capacity, expression of endoplasmic reticulum stress proteins, anatomical and physiological changes in the coronary arteries, changes in nitric oxide production, adaptational changes in cardiac mitochondria, increased autophagy, and improved function of sarcolemmal and/or mitochondrial ATP-sensitive potassium channels. It is currently unclear which of these protective mechanisms are essential for exercise-induced cardioprotection. However, most investigations focus on sarcolemmal KATP channels, NO production, and mitochondrial changes although it is very likely that other mechanisms may also exist. This paper discusses current information about these aforementioned topics and does not consider potentially important adaptations within blood or the autonomic nervous system. A better understanding of the molecular basis of exercise-induced cardioprotection will help to develop better therapeutic strategies. |
| format | Article |
| id | doaj-art-0dd7177a304c4ac8995adc7f2129793c |
| institution | Kabale University |
| issn | 2090-0597 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-0dd7177a304c4ac8995adc7f2129793c2025-02-03T06:45:20ZengWileyCardiology Research and Practice2090-05972011-01-01201110.4061/2011/972807972807Molecular Mechanisms in Exercise-Induced CardioprotectionSaeid Golbidi0Ismail Laher1Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, CanadaDepartment of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, CanadaPhysical inactivity is increasingly recognized as modifiable behavioral risk factor for cardiovascular diseases. A partial list of proposed mechanisms for exercise-induced cardioprotection include induction of heat shock proteins, increase in cardiac antioxidant capacity, expression of endoplasmic reticulum stress proteins, anatomical and physiological changes in the coronary arteries, changes in nitric oxide production, adaptational changes in cardiac mitochondria, increased autophagy, and improved function of sarcolemmal and/or mitochondrial ATP-sensitive potassium channels. It is currently unclear which of these protective mechanisms are essential for exercise-induced cardioprotection. However, most investigations focus on sarcolemmal KATP channels, NO production, and mitochondrial changes although it is very likely that other mechanisms may also exist. This paper discusses current information about these aforementioned topics and does not consider potentially important adaptations within blood or the autonomic nervous system. A better understanding of the molecular basis of exercise-induced cardioprotection will help to develop better therapeutic strategies.http://dx.doi.org/10.4061/2011/972807 |
| spellingShingle | Saeid Golbidi Ismail Laher Molecular Mechanisms in Exercise-Induced Cardioprotection Cardiology Research and Practice |
| title | Molecular Mechanisms in Exercise-Induced Cardioprotection |
| title_full | Molecular Mechanisms in Exercise-Induced Cardioprotection |
| title_fullStr | Molecular Mechanisms in Exercise-Induced Cardioprotection |
| title_full_unstemmed | Molecular Mechanisms in Exercise-Induced Cardioprotection |
| title_short | Molecular Mechanisms in Exercise-Induced Cardioprotection |
| title_sort | molecular mechanisms in exercise induced cardioprotection |
| url | http://dx.doi.org/10.4061/2011/972807 |
| work_keys_str_mv | AT saeidgolbidi molecularmechanismsinexerciseinducedcardioprotection AT ismaillaher molecularmechanismsinexerciseinducedcardioprotection |