Successful Treatment of Fungal Dermatitis in a Bottlenose Dolphin (<i>Tursiops truncatus</i>)
In recent decades, many fungi have emerged as major causes of disease in marine mammals. This study reports on the detection of filamentous fungi in the subcutaneous tissue and wound surface on the tail fin of a managed bottlenose dolphin (<i>Tursiops truncatus</i>) emaciated due to seve...
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2025-01-01
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| author | Takashi Kamio Honoka Nojo Rui Kano Mami Murakami Yukako Odani Koji Kanda Tomoko Mori Yuichiro Akune Masanori Kurita Ayaka Okada Yasuo Inoshima |
| author_facet | Takashi Kamio Honoka Nojo Rui Kano Mami Murakami Yukako Odani Koji Kanda Tomoko Mori Yuichiro Akune Masanori Kurita Ayaka Okada Yasuo Inoshima |
| author_sort | Takashi Kamio |
| collection | DOAJ |
| description | In recent decades, many fungi have emerged as major causes of disease in marine mammals. This study reports on the detection of filamentous fungi in the subcutaneous tissue and wound surface on the tail fin of a managed bottlenose dolphin (<i>Tursiops truncatus</i>) emaciated due to severe digestive problems. Immunosuppression by chronic diseases and starvation decreased resistance against opportunistic infections. Sequencing analysis revealed that the fungi on the wound surface were <i>Fusarium oxysporum,</i> and antifungal susceptibility testing was performed. In the subcutaneous tissue, dematiaceous fungi were identified using histopathological examination. Combination antifungal treatment with voriconazole and terbinafine and surgical resection were performed, in addition to daily debridement with polyaminopropyl biguanide (PHMB) and betaine. Hematological examination revealed a reduction in inflammatory markers after antifungal treatment and surgical resection of necrotic tissue on the edge of the tail fin. The co-administration of synergistic agents voriconazole and terbinafine, in conjunction with surgical debridement, successfully eliminated pheohyphomycosis and fusariomycosis in the bottlenose dolphin. Wound healing was achieved using systematic antifungals and daily debridement with PHMB and betaine. This is the first report of successful treatment of pheohyphomycosis and fusariomycosis in a bottlenose dolphin using voriconazole and terbinafine combination therapy and surgical resection. |
| format | Article |
| id | doaj-art-0dc571334d744a55b76b79a3cdc4282e |
| institution | Kabale University |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-0dc571334d744a55b76b79a3cdc4282e2025-01-24T13:42:40ZengMDPI AGMicroorganisms2076-26072025-01-0113110610.3390/microorganisms13010106Successful Treatment of Fungal Dermatitis in a Bottlenose Dolphin (<i>Tursiops truncatus</i>)Takashi Kamio0Honoka Nojo1Rui Kano2Mami Murakami3Yukako Odani4Koji Kanda5Tomoko Mori6Yuichiro Akune7Masanori Kurita8Ayaka Okada9Yasuo Inoshima10Port of Nagoya Public Aquarium, Nagoya Port Foundation, 1-3 Minato-machi, Minato-ku, Nagoya 455-0033, JapanTeikyo University Institute of Medical Mycology (TIMM), Teikyo University, 359 Otsuka, Hachioji 192-0395, JapanTeikyo University Institute of Medical Mycology (TIMM), Teikyo University, 359 Otsuka, Hachioji 192-0395, JapanLaboratory of Veterinary Clinical Pathology, Joint Department of Veterinary Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1193, JapanPort of Nagoya Public Aquarium, Nagoya Port Foundation, 1-3 Minato-machi, Minato-ku, Nagoya 455-0033, JapanPort of Nagoya Public Aquarium, Nagoya Port Foundation, 1-3 Minato-machi, Minato-ku, Nagoya 455-0033, JapanPort of Nagoya Public Aquarium, Nagoya Port Foundation, 1-3 Minato-machi, Minato-ku, Nagoya 455-0033, JapanPort of Nagoya Public Aquarium, Nagoya Port Foundation, 1-3 Minato-machi, Minato-ku, Nagoya 455-0033, JapanPort of Nagoya Public Aquarium, Nagoya Port Foundation, 1-3 Minato-machi, Minato-ku, Nagoya 455-0033, JapanLaboratory of Food and Environmental Hygiene, Joint Department of Veterinary Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1193, JapanLaboratory of Food and Environmental Hygiene, Joint Department of Veterinary Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1193, JapanIn recent decades, many fungi have emerged as major causes of disease in marine mammals. This study reports on the detection of filamentous fungi in the subcutaneous tissue and wound surface on the tail fin of a managed bottlenose dolphin (<i>Tursiops truncatus</i>) emaciated due to severe digestive problems. Immunosuppression by chronic diseases and starvation decreased resistance against opportunistic infections. Sequencing analysis revealed that the fungi on the wound surface were <i>Fusarium oxysporum,</i> and antifungal susceptibility testing was performed. In the subcutaneous tissue, dematiaceous fungi were identified using histopathological examination. Combination antifungal treatment with voriconazole and terbinafine and surgical resection were performed, in addition to daily debridement with polyaminopropyl biguanide (PHMB) and betaine. Hematological examination revealed a reduction in inflammatory markers after antifungal treatment and surgical resection of necrotic tissue on the edge of the tail fin. The co-administration of synergistic agents voriconazole and terbinafine, in conjunction with surgical debridement, successfully eliminated pheohyphomycosis and fusariomycosis in the bottlenose dolphin. Wound healing was achieved using systematic antifungals and daily debridement with PHMB and betaine. This is the first report of successful treatment of pheohyphomycosis and fusariomycosis in a bottlenose dolphin using voriconazole and terbinafine combination therapy and surgical resection.https://www.mdpi.com/2076-2607/13/1/106debridementdematiaceous fungi<i>Fusarium oxysporum</i>pheohyphomycosispolyaminopropyl biguanide and betaineterbinafine |
| spellingShingle | Takashi Kamio Honoka Nojo Rui Kano Mami Murakami Yukako Odani Koji Kanda Tomoko Mori Yuichiro Akune Masanori Kurita Ayaka Okada Yasuo Inoshima Successful Treatment of Fungal Dermatitis in a Bottlenose Dolphin (<i>Tursiops truncatus</i>) Microorganisms debridement dematiaceous fungi <i>Fusarium oxysporum</i> pheohyphomycosis polyaminopropyl biguanide and betaine terbinafine |
| title | Successful Treatment of Fungal Dermatitis in a Bottlenose Dolphin (<i>Tursiops truncatus</i>) |
| title_full | Successful Treatment of Fungal Dermatitis in a Bottlenose Dolphin (<i>Tursiops truncatus</i>) |
| title_fullStr | Successful Treatment of Fungal Dermatitis in a Bottlenose Dolphin (<i>Tursiops truncatus</i>) |
| title_full_unstemmed | Successful Treatment of Fungal Dermatitis in a Bottlenose Dolphin (<i>Tursiops truncatus</i>) |
| title_short | Successful Treatment of Fungal Dermatitis in a Bottlenose Dolphin (<i>Tursiops truncatus</i>) |
| title_sort | successful treatment of fungal dermatitis in a bottlenose dolphin i tursiops truncatus i |
| topic | debridement dematiaceous fungi <i>Fusarium oxysporum</i> pheohyphomycosis polyaminopropyl biguanide and betaine terbinafine |
| url | https://www.mdpi.com/2076-2607/13/1/106 |
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