Mutual associations among responsiveness to differential diagnostic tests for Cushing’s disease, tumor size, and somatostatin receptor 5 expression in corticotroph tumors
There are differences in the responsiveness to differential diagnostic tests for Cushing’s disease (CD), corticotroph tumor size, and the somatostatin receptor (SSTR) 5 expression in corticotroph tumors between CD patients. The differences in SSTR5 expression are particularly significant for identif...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Japan Endocrine Society
2025-01-01
|
| Series: | Endocrine Journal |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/72/1/72_EJ24-0344/_html/-char/en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591889764712448 |
|---|---|
| author | Karolina Budzen Kosuke Mukai Yuto Mitsui Michio Otsuki Atsunori Fukuhara Satoru Oshino Youichi Saitoh Masaharu Kohara Eiichi Morii Iichiro Shimomura |
| author_facet | Karolina Budzen Kosuke Mukai Yuto Mitsui Michio Otsuki Atsunori Fukuhara Satoru Oshino Youichi Saitoh Masaharu Kohara Eiichi Morii Iichiro Shimomura |
| author_sort | Karolina Budzen |
| collection | DOAJ |
| description | There are differences in the responsiveness to differential diagnostic tests for Cushing’s disease (CD), corticotroph tumor size, and the somatostatin receptor (SSTR) 5 expression in corticotroph tumors between CD patients. The differences in SSTR5 expression are particularly significant for identifying therapeutic targets for CD. However, prospective predictors of SSTR5 expression remain unclear. Thus, our objective was to elucidate the relationships among these clinical characteristics of CD, including SSTR5 expression. In 27 hospitalized patients with CD at Osaka University Hospital, Osaka, Japan, associations between corticotroph tumor diameter, the response of ACTH and cortisol to differential diagnostic tests for CD (CRH, desmopressin [DDAVP], and high-dose dexamethasone suppression test [HDDST]), the ACTH/cortisol index, and the SSTR5 immunoreactive score were retrospectively investigated. The response to differential diagnostic tests, ACTH/cortisol index, tumor diameter, and SSTR5 expression were significantly related (vs. tumor diameter [CRH: r = –0.54; DDAVP: r = –0.54; HDDST r = –0.67; ACTH/cortisol index: r = 0.76; SSTR5: r = –0.61], vs. CRH [DDAVP: r = 0.63, HDDST: r = 0.72, ACTH/cortisol index: r = –0.45; SSTR5: r = 0.56], vs. DDAVP [HDDST: r = 0.66; ACTH/cortisol index: r = –0.46; SSTR5: r = 0.76], vs. HDDST [ACTH/cortisol index: r = –0.62; SSTR5: r = 0.77], ACTH/cortisol index vs. SSTR5: r = –0.67). The areas under the receiver operating characteristic curve for the prediction of high SSTR5 expression via the CRH test, DDAVP test, HDDST, ACTH/cortisol index, and tumor diameter were 0.79, 0.87, 0.80, 0.71, and 0.71, respectively. Tests for differential diagnosis of CD, the ACTH/cortisol index, and the corticotroph tumor diameter have the potential for identifying SSTR5 expression in corticotroph tumors. These parameters may reflect the biological characteristics of corticotroph tumors. |
| format | Article |
| id | doaj-art-0dc3f23410b24f7183e538464dc953d5 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-0dc3f23410b24f7183e538464dc953d52025-01-22T05:36:47ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402025-01-017219310210.1507/endocrj.EJ24-0344endocrjMutual associations among responsiveness to differential diagnostic tests for Cushing’s disease, tumor size, and somatostatin receptor 5 expression in corticotroph tumorsKarolina Budzen0Kosuke Mukai1Yuto Mitsui2Michio Otsuki3Atsunori Fukuhara4Satoru Oshino5Youichi Saitoh6Masaharu Kohara7Eiichi Morii8Iichiro Shimomura9Departments of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanDepartments of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanDepartments of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanDepartment of Endocrinology, Tokyo Women’s Medical University Graduate School of Medical Science, Tokyo 162-8666, JapanDepartments of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanDepartment of Neurosurgery, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanTokuyukai Rehabilitation Clinic, Osaka 560-0083, JapanPathology, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanPathology, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanDepartments of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanThere are differences in the responsiveness to differential diagnostic tests for Cushing’s disease (CD), corticotroph tumor size, and the somatostatin receptor (SSTR) 5 expression in corticotroph tumors between CD patients. The differences in SSTR5 expression are particularly significant for identifying therapeutic targets for CD. However, prospective predictors of SSTR5 expression remain unclear. Thus, our objective was to elucidate the relationships among these clinical characteristics of CD, including SSTR5 expression. In 27 hospitalized patients with CD at Osaka University Hospital, Osaka, Japan, associations between corticotroph tumor diameter, the response of ACTH and cortisol to differential diagnostic tests for CD (CRH, desmopressin [DDAVP], and high-dose dexamethasone suppression test [HDDST]), the ACTH/cortisol index, and the SSTR5 immunoreactive score were retrospectively investigated. The response to differential diagnostic tests, ACTH/cortisol index, tumor diameter, and SSTR5 expression were significantly related (vs. tumor diameter [CRH: r = –0.54; DDAVP: r = –0.54; HDDST r = –0.67; ACTH/cortisol index: r = 0.76; SSTR5: r = –0.61], vs. CRH [DDAVP: r = 0.63, HDDST: r = 0.72, ACTH/cortisol index: r = –0.45; SSTR5: r = 0.56], vs. DDAVP [HDDST: r = 0.66; ACTH/cortisol index: r = –0.46; SSTR5: r = 0.76], vs. HDDST [ACTH/cortisol index: r = –0.62; SSTR5: r = 0.77], ACTH/cortisol index vs. SSTR5: r = –0.67). The areas under the receiver operating characteristic curve for the prediction of high SSTR5 expression via the CRH test, DDAVP test, HDDST, ACTH/cortisol index, and tumor diameter were 0.79, 0.87, 0.80, 0.71, and 0.71, respectively. Tests for differential diagnosis of CD, the ACTH/cortisol index, and the corticotroph tumor diameter have the potential for identifying SSTR5 expression in corticotroph tumors. These parameters may reflect the biological characteristics of corticotroph tumors.https://www.jstage.jst.go.jp/article/endocrj/72/1/72_EJ24-0344/_html/-char/encorticotroph tumor sizecrh testddavp testhigh-dose dexamethasone suppression testsomatostatin receptor 5 |
| spellingShingle | Karolina Budzen Kosuke Mukai Yuto Mitsui Michio Otsuki Atsunori Fukuhara Satoru Oshino Youichi Saitoh Masaharu Kohara Eiichi Morii Iichiro Shimomura Mutual associations among responsiveness to differential diagnostic tests for Cushing’s disease, tumor size, and somatostatin receptor 5 expression in corticotroph tumors Endocrine Journal corticotroph tumor size crh test ddavp test high-dose dexamethasone suppression test somatostatin receptor 5 |
| title | Mutual associations among responsiveness to differential diagnostic tests for Cushing’s disease, tumor size, and somatostatin receptor 5 expression in corticotroph tumors |
| title_full | Mutual associations among responsiveness to differential diagnostic tests for Cushing’s disease, tumor size, and somatostatin receptor 5 expression in corticotroph tumors |
| title_fullStr | Mutual associations among responsiveness to differential diagnostic tests for Cushing’s disease, tumor size, and somatostatin receptor 5 expression in corticotroph tumors |
| title_full_unstemmed | Mutual associations among responsiveness to differential diagnostic tests for Cushing’s disease, tumor size, and somatostatin receptor 5 expression in corticotroph tumors |
| title_short | Mutual associations among responsiveness to differential diagnostic tests for Cushing’s disease, tumor size, and somatostatin receptor 5 expression in corticotroph tumors |
| title_sort | mutual associations among responsiveness to differential diagnostic tests for cushing s disease tumor size and somatostatin receptor 5 expression in corticotroph tumors |
| topic | corticotroph tumor size crh test ddavp test high-dose dexamethasone suppression test somatostatin receptor 5 |
| url | https://www.jstage.jst.go.jp/article/endocrj/72/1/72_EJ24-0344/_html/-char/en |
| work_keys_str_mv | AT karolinabudzen mutualassociationsamongresponsivenesstodifferentialdiagnostictestsforcushingsdiseasetumorsizeandsomatostatinreceptor5expressionincorticotrophtumors AT kosukemukai mutualassociationsamongresponsivenesstodifferentialdiagnostictestsforcushingsdiseasetumorsizeandsomatostatinreceptor5expressionincorticotrophtumors AT yutomitsui mutualassociationsamongresponsivenesstodifferentialdiagnostictestsforcushingsdiseasetumorsizeandsomatostatinreceptor5expressionincorticotrophtumors AT michiootsuki mutualassociationsamongresponsivenesstodifferentialdiagnostictestsforcushingsdiseasetumorsizeandsomatostatinreceptor5expressionincorticotrophtumors AT atsunorifukuhara mutualassociationsamongresponsivenesstodifferentialdiagnostictestsforcushingsdiseasetumorsizeandsomatostatinreceptor5expressionincorticotrophtumors AT satoruoshino mutualassociationsamongresponsivenesstodifferentialdiagnostictestsforcushingsdiseasetumorsizeandsomatostatinreceptor5expressionincorticotrophtumors AT youichisaitoh mutualassociationsamongresponsivenesstodifferentialdiagnostictestsforcushingsdiseasetumorsizeandsomatostatinreceptor5expressionincorticotrophtumors AT masaharukohara mutualassociationsamongresponsivenesstodifferentialdiagnostictestsforcushingsdiseasetumorsizeandsomatostatinreceptor5expressionincorticotrophtumors AT eiichimorii mutualassociationsamongresponsivenesstodifferentialdiagnostictestsforcushingsdiseasetumorsizeandsomatostatinreceptor5expressionincorticotrophtumors AT iichiroshimomura mutualassociationsamongresponsivenesstodifferentialdiagnostictestsforcushingsdiseasetumorsizeandsomatostatinreceptor5expressionincorticotrophtumors |