Cortical Neurotransmitters Measured by Magnetic Resonance Spectroscopy Change Following Traumatic Brachial Plexus Injury
Introduction GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. In response to injury within the central nervous system, GABA promotes cortical plasticity and represents a potential pharmacological target to improve functional recovery. However, it is unclea...
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Georg Thieme Verlag KG
2025-01-01
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| Series: | Journal of Brachial Plexus and Peripheral Nerve Injury |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/a-2505-5657 |
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| author | Ryckie G. Wade Gráinne Bourke Alexandra M. Olaru Stephen R. Williams David Shelley Sven Plein Robert D. Bains James D. Bedford Lucy E. Homer Newton Chye Yew Ng Laura Parkes Caroline Lea-Carnall |
| author_facet | Ryckie G. Wade Gráinne Bourke Alexandra M. Olaru Stephen R. Williams David Shelley Sven Plein Robert D. Bains James D. Bedford Lucy E. Homer Newton Chye Yew Ng Laura Parkes Caroline Lea-Carnall |
| author_sort | Ryckie G. Wade |
| collection | DOAJ |
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Introduction GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. In response to injury within the central nervous system, GABA promotes cortical plasticity and represents a potential pharmacological target to improve functional recovery. However, it is unclear how GABA changes in the brain after traumatic brachial plexus injuries (tBPIs) which represents the rationale for this pilot study. |
| format | Article |
| id | doaj-art-0dbf4d9fe0094932a084db5fa9ce6036 |
| institution | Kabale University |
| issn | 1749-7221 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Journal of Brachial Plexus and Peripheral Nerve Injury |
| spelling | doaj-art-0dbf4d9fe0094932a084db5fa9ce60362025-01-29T01:49:33ZengGeorg Thieme Verlag KGJournal of Brachial Plexus and Peripheral Nerve Injury1749-72212025-01-012001e16e2510.1055/a-2505-5657Cortical Neurotransmitters Measured by Magnetic Resonance Spectroscopy Change Following Traumatic Brachial Plexus InjuryRyckie G. Wade0https://orcid.org/0000-0001-8365-6547Gráinne Bourke1https://orcid.org/0000-0003-0059-8543Alexandra M. Olaru2https://orcid.org/0000-0002-2244-1048Stephen R. Williams3https://orcid.org/0000-0001-5940-1675David Shelley4Sven Plein5https://orcid.org/0000-0002-0997-4384Robert D. Bains6James D. Bedford7https://orcid.org/0000-0001-9599-5802Lucy E. Homer Newton8https://orcid.org/0000-0002-9513-3492Chye Yew Ng9https://orcid.org/0000-0002-2589-6857Laura Parkes10https://orcid.org/0000-0001-6488-507XCaroline Lea-Carnall11https://orcid.org/0000-0001-6814-3356Department of Plastic and Reconstructive Surgery, Leeds Teaching Hospitals Trust, Leeds, United KingdomDepartment of Plastic and Reconstructive Surgery, Leeds Teaching Hospitals Trust, Leeds, United KingdomSiemens Healthcare Ltd., Park View, Watchmoor Park, Camberley, Surrey, United KingdomDivision of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, United KingdomThe Advanced Imaging Centre, University of Leeds, Leeds, United KingdomLeeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United KingdomDepartment of Plastic and Reconstructive Surgery, Leeds Teaching Hospitals Trust, Leeds, United KingdomDepartment of Plastic Surgery and Burns, Manchester University NHS Foundation Trust, United KingdomDepartment of Plastic Surgery and Burns, Manchester University NHS Foundation Trust, United KingdomWrightington Wigan and Leigh NHS Foundation Trust, Wigan, United KingdomSchool of Health Sciences, Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United KingdomSchool of Health Sciences, Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom Introduction GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. In response to injury within the central nervous system, GABA promotes cortical plasticity and represents a potential pharmacological target to improve functional recovery. However, it is unclear how GABA changes in the brain after traumatic brachial plexus injuries (tBPIs) which represents the rationale for this pilot study.http://www.thieme-connect.de/DOI/DOI?10.1055/a-2505-5657brachial plexus injuryspectroscopyplasticitymotorsensoryneurometabolitesGABANAA |
| spellingShingle | Ryckie G. Wade Gráinne Bourke Alexandra M. Olaru Stephen R. Williams David Shelley Sven Plein Robert D. Bains James D. Bedford Lucy E. Homer Newton Chye Yew Ng Laura Parkes Caroline Lea-Carnall Cortical Neurotransmitters Measured by Magnetic Resonance Spectroscopy Change Following Traumatic Brachial Plexus Injury Journal of Brachial Plexus and Peripheral Nerve Injury brachial plexus injury spectroscopy plasticity motor sensory neurometabolites GABA NAA |
| title | Cortical Neurotransmitters Measured by Magnetic Resonance Spectroscopy Change Following Traumatic Brachial Plexus Injury |
| title_full | Cortical Neurotransmitters Measured by Magnetic Resonance Spectroscopy Change Following Traumatic Brachial Plexus Injury |
| title_fullStr | Cortical Neurotransmitters Measured by Magnetic Resonance Spectroscopy Change Following Traumatic Brachial Plexus Injury |
| title_full_unstemmed | Cortical Neurotransmitters Measured by Magnetic Resonance Spectroscopy Change Following Traumatic Brachial Plexus Injury |
| title_short | Cortical Neurotransmitters Measured by Magnetic Resonance Spectroscopy Change Following Traumatic Brachial Plexus Injury |
| title_sort | cortical neurotransmitters measured by magnetic resonance spectroscopy change following traumatic brachial plexus injury |
| topic | brachial plexus injury spectroscopy plasticity motor sensory neurometabolites GABA NAA |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/a-2505-5657 |
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