Cortical Neurotransmitters Measured by Magnetic Resonance Spectroscopy Change Following Traumatic Brachial Plexus Injury

Cortical Neurotransmitters Measured by Magnetic Resonance Spectroscopy Change Following Traumatic Brachial Plexus Injury

Introduction GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. In response to injury within the central nervous system, GABA promotes cortical plasticity and represents a potential pharmacological target to improve functional recovery. However, it is unclea...

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Main Authors: Ryckie G. Wade, Gráinne Bourke, Alexandra M. Olaru, Stephen R. Williams, David Shelley, Sven Plein, Robert D. Bains, James D. Bedford, Lucy E. Homer Newton, Chye Yew Ng, Laura Parkes, Caroline Lea-Carnall
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2025-01-01
Series:Journal of Brachial Plexus and Peripheral Nerve Injury
Subjects:
brachial plexus injury
spectroscopy
plasticity
motor
sensory
neurometabolites
GABA
NAA
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/a-2505-5657
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Summary:Introduction GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. In response to injury within the central nervous system, GABA promotes cortical plasticity and represents a potential pharmacological target to improve functional recovery. However, it is unclear how GABA changes in the brain after traumatic brachial plexus injuries (tBPIs) which represents the rationale for this pilot study.
ISSN:1749-7221

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