Serum Cytokines in Young Pediatric Patients with Congenital Cardiac Shunts and Altered Pulmonary Hemodynamics
Background and Objective. Inflammation is central in the pathogenesis of pulmonary hypertension. We investigated how serum cytokines correlate with clinical features, hemodynamics, and lung histology in young patients with pulmonary hypertension associated with congenital cardiac shunts. Design. Pro...
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/7672048 |
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| author | Leína Zorzanelli Nair Yukie Maeda Mariana Meira Clavé Vera Demarchi Aiello Marlene Rabinovitch Antonio Augusto Lopes |
| author_facet | Leína Zorzanelli Nair Yukie Maeda Mariana Meira Clavé Vera Demarchi Aiello Marlene Rabinovitch Antonio Augusto Lopes |
| author_sort | Leína Zorzanelli |
| collection | DOAJ |
| description | Background and Objective. Inflammation is central in the pathogenesis of pulmonary hypertension. We investigated how serum cytokines correlate with clinical features, hemodynamics, and lung histology in young patients with pulmonary hypertension associated with congenital cardiac shunts. Design. Prospective, observational study. Methods and Results. Patients (n=44) were aged 2.6 to 37.6 months. Group I patients (n=31) were characterized by pulmonary congestion and higher pulmonary blood flow compared to group II (p=0.022), with no need for preoperative cardiac catheterization. Group II patients (n=13) had no congestive features. At catheterization, they had elevated pulmonary vascular resistance (5.7 [4.4–7.4] Wood units·m2, geometric mean with 95% CI). Cytokines were measured by chemiluminescence. Macrophage migration inhibitory factor (MIF) was found to be inversely related to pulmonary blood flow (r=-0.33, p=0.026) and was higher in group II (high pulmonary vascular resistance) compared to group I (high pulmonary blood flow) (p=0.017). In contrast, RANTES chemokine (regulated on activation, normal T cell expressed and secreted) was characteristically elevated in Group I (p=0.022). Interleukin 16 was also negatively related to pulmonary blood flow (rS=-0.33, p=0.029) and was higher in patients with obstructive vasculopathy at intraoperative lung biopsy (p=0.021). Conclusion. Cytokines seem to be important and differentially regulated in subpopulations of young patients with cardiac shunts. |
| format | Article |
| id | doaj-art-0dbdb29151194fffaca232ae79628c4e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0dbdb29151194fffaca232ae79628c4e2025-02-03T05:51:20ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/76720487672048Serum Cytokines in Young Pediatric Patients with Congenital Cardiac Shunts and Altered Pulmonary HemodynamicsLeína Zorzanelli0Nair Yukie Maeda1Mariana Meira Clavé2Vera Demarchi Aiello3Marlene Rabinovitch4Antonio Augusto Lopes5Heart Institute, University of São Paulo School of Medicine, São Paulo, SP, BrazilPró-Sangue Foundation, São Paulo, SP, BrazilHeart Institute, University of São Paulo School of Medicine, São Paulo, SP, BrazilHeart Institute, University of São Paulo School of Medicine, São Paulo, SP, BrazilStanford University School of Medicine, Stanford, CA, USAHeart Institute, University of São Paulo School of Medicine, São Paulo, SP, BrazilBackground and Objective. Inflammation is central in the pathogenesis of pulmonary hypertension. We investigated how serum cytokines correlate with clinical features, hemodynamics, and lung histology in young patients with pulmonary hypertension associated with congenital cardiac shunts. Design. Prospective, observational study. Methods and Results. Patients (n=44) were aged 2.6 to 37.6 months. Group I patients (n=31) were characterized by pulmonary congestion and higher pulmonary blood flow compared to group II (p=0.022), with no need for preoperative cardiac catheterization. Group II patients (n=13) had no congestive features. At catheterization, they had elevated pulmonary vascular resistance (5.7 [4.4–7.4] Wood units·m2, geometric mean with 95% CI). Cytokines were measured by chemiluminescence. Macrophage migration inhibitory factor (MIF) was found to be inversely related to pulmonary blood flow (r=-0.33, p=0.026) and was higher in group II (high pulmonary vascular resistance) compared to group I (high pulmonary blood flow) (p=0.017). In contrast, RANTES chemokine (regulated on activation, normal T cell expressed and secreted) was characteristically elevated in Group I (p=0.022). Interleukin 16 was also negatively related to pulmonary blood flow (rS=-0.33, p=0.029) and was higher in patients with obstructive vasculopathy at intraoperative lung biopsy (p=0.021). Conclusion. Cytokines seem to be important and differentially regulated in subpopulations of young patients with cardiac shunts.http://dx.doi.org/10.1155/2016/7672048 |
| spellingShingle | Leína Zorzanelli Nair Yukie Maeda Mariana Meira Clavé Vera Demarchi Aiello Marlene Rabinovitch Antonio Augusto Lopes Serum Cytokines in Young Pediatric Patients with Congenital Cardiac Shunts and Altered Pulmonary Hemodynamics Mediators of Inflammation |
| title | Serum Cytokines in Young Pediatric Patients with Congenital Cardiac Shunts and Altered Pulmonary Hemodynamics |
| title_full | Serum Cytokines in Young Pediatric Patients with Congenital Cardiac Shunts and Altered Pulmonary Hemodynamics |
| title_fullStr | Serum Cytokines in Young Pediatric Patients with Congenital Cardiac Shunts and Altered Pulmonary Hemodynamics |
| title_full_unstemmed | Serum Cytokines in Young Pediatric Patients with Congenital Cardiac Shunts and Altered Pulmonary Hemodynamics |
| title_short | Serum Cytokines in Young Pediatric Patients with Congenital Cardiac Shunts and Altered Pulmonary Hemodynamics |
| title_sort | serum cytokines in young pediatric patients with congenital cardiac shunts and altered pulmonary hemodynamics |
| url | http://dx.doi.org/10.1155/2016/7672048 |
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