Delivering Volumetric Hyperthermia to Head and Neck Cancer Patient-Specific Models Using an Ultrasound Spherical Random Phased Array Transducer
In exploring adjuvant therapies for head and neck cancer, hyperthermia (40–45 °C) has shown efficacy in enhancing chemotherapy and radiation, as well as the delivery of liposomal drugs. Current hyperthermia treatments, however, struggle to reach large deep tumors uniformly and non-invasively. This s...
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2024-12-01
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| author | Muhammad Zubair Imad Uddin Robert Dickinson Chris J. Diederich |
| author_facet | Muhammad Zubair Imad Uddin Robert Dickinson Chris J. Diederich |
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| description | In exploring adjuvant therapies for head and neck cancer, hyperthermia (40–45 °C) has shown efficacy in enhancing chemotherapy and radiation, as well as the delivery of liposomal drugs. Current hyperthermia treatments, however, struggle to reach large deep tumors uniformly and non-invasively. This study investigates the feasibility of delivering targeted uniform hyperthermia deep into the tissue using a non-invasive ultrasound spherical random phased array transducer. Simulations in 3D patient-specific models for thyroid and oropharyngeal cancers assessed the transducer’s proficiency. The transducer consisting of 256 elements randomly positioned on a spherical shell, operated at a frequency of 1 MHz with various phasing schemes and power modulations to analyze 40, 41, and 43 °C isothermal volumes and the penetration depth of the heating volume, along with temperature uniformity within the target area using T10, T50, and T90 temperatures, across different tumor models. Intensity distributions and volumetric temperature contours were calculated to define moderate hyperthermia boundaries. The results indicated the array’s ability to produce controlled heating volumes from 1 to 48 cm<sup>3</sup> at 40 °C, 0.35 to 27 cm<sup>3</sup> at 41 °C, and 0.1 to 8 cm<sup>3</sup> at 43 °C. The heating depths ranged from 7 to 39 mm minimum and 52 to 59 mm maximum, measured from the skin’s inner surface. The transducer, with optimal phasing and water-cooled bolus, confined the heating to the targeted regions effectively. Multifocal sonications also improved the heating homogeneity, reducing the length-to-diameter ratio by 38% when using eight foci versus a single one. This approach shows potential for treating a range of tumors, notably deep-seated and challenging oropharyngeal cancers. |
| format | Article |
| id | doaj-art-0db683654938429e896cd5809ca1d43d |
| institution | Kabale University |
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| spelling | doaj-art-0db683654938429e896cd5809ca1d43d2025-01-24T13:22:57ZengMDPI AGBioengineering2306-53542024-12-011211410.3390/bioengineering12010014Delivering Volumetric Hyperthermia to Head and Neck Cancer Patient-Specific Models Using an Ultrasound Spherical Random Phased Array TransducerMuhammad Zubair0Imad Uddin1Robert Dickinson2Chris J. Diederich3Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94115, USADepartment of Cardiology, Hayat Abad Medical Complex, Peshawar 23301, PakistanDepartment of Bioengineering, Imperial College London, London SW7 2AZ, UKDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94115, USAIn exploring adjuvant therapies for head and neck cancer, hyperthermia (40–45 °C) has shown efficacy in enhancing chemotherapy and radiation, as well as the delivery of liposomal drugs. Current hyperthermia treatments, however, struggle to reach large deep tumors uniformly and non-invasively. This study investigates the feasibility of delivering targeted uniform hyperthermia deep into the tissue using a non-invasive ultrasound spherical random phased array transducer. Simulations in 3D patient-specific models for thyroid and oropharyngeal cancers assessed the transducer’s proficiency. The transducer consisting of 256 elements randomly positioned on a spherical shell, operated at a frequency of 1 MHz with various phasing schemes and power modulations to analyze 40, 41, and 43 °C isothermal volumes and the penetration depth of the heating volume, along with temperature uniformity within the target area using T10, T50, and T90 temperatures, across different tumor models. Intensity distributions and volumetric temperature contours were calculated to define moderate hyperthermia boundaries. The results indicated the array’s ability to produce controlled heating volumes from 1 to 48 cm<sup>3</sup> at 40 °C, 0.35 to 27 cm<sup>3</sup> at 41 °C, and 0.1 to 8 cm<sup>3</sup> at 43 °C. The heating depths ranged from 7 to 39 mm minimum and 52 to 59 mm maximum, measured from the skin’s inner surface. The transducer, with optimal phasing and water-cooled bolus, confined the heating to the targeted regions effectively. Multifocal sonications also improved the heating homogeneity, reducing the length-to-diameter ratio by 38% when using eight foci versus a single one. This approach shows potential for treating a range of tumors, notably deep-seated and challenging oropharyngeal cancers.https://www.mdpi.com/2306-5354/12/1/14hyperthermiadrug deliveryfocused ultrasoundphased arrayhead and neck cancerpatient-specific modeling |
| spellingShingle | Muhammad Zubair Imad Uddin Robert Dickinson Chris J. Diederich Delivering Volumetric Hyperthermia to Head and Neck Cancer Patient-Specific Models Using an Ultrasound Spherical Random Phased Array Transducer Bioengineering hyperthermia drug delivery focused ultrasound phased array head and neck cancer patient-specific modeling |
| title | Delivering Volumetric Hyperthermia to Head and Neck Cancer Patient-Specific Models Using an Ultrasound Spherical Random Phased Array Transducer |
| title_full | Delivering Volumetric Hyperthermia to Head and Neck Cancer Patient-Specific Models Using an Ultrasound Spherical Random Phased Array Transducer |
| title_fullStr | Delivering Volumetric Hyperthermia to Head and Neck Cancer Patient-Specific Models Using an Ultrasound Spherical Random Phased Array Transducer |
| title_full_unstemmed | Delivering Volumetric Hyperthermia to Head and Neck Cancer Patient-Specific Models Using an Ultrasound Spherical Random Phased Array Transducer |
| title_short | Delivering Volumetric Hyperthermia to Head and Neck Cancer Patient-Specific Models Using an Ultrasound Spherical Random Phased Array Transducer |
| title_sort | delivering volumetric hyperthermia to head and neck cancer patient specific models using an ultrasound spherical random phased array transducer |
| topic | hyperthermia drug delivery focused ultrasound phased array head and neck cancer patient-specific modeling |
| url | https://www.mdpi.com/2306-5354/12/1/14 |
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