Application of Bionanomaterials in Tumor Immune Microenvironment Therapy
Targeted therapy for the cancer immune system has become a clinical reality with remarkable success. Immune checkpoint blockade therapy and chimeric antigen receptor T-cell (CAR-T) immunotherapy are clinically effective in a variety of cancers. However, the clinical utility of immunotherapy in cance...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/6663035 |
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| _version_ | 1832560018358009856 |
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| author | Jiawei Wang Yan Bao Yandan Yao |
| author_facet | Jiawei Wang Yan Bao Yandan Yao |
| author_sort | Jiawei Wang |
| collection | DOAJ |
| description | Targeted therapy for the cancer immune system has become a clinical reality with remarkable success. Immune checkpoint blockade therapy and chimeric antigen receptor T-cell (CAR-T) immunotherapy are clinically effective in a variety of cancers. However, the clinical utility of immunotherapy in cancer is limited by severe off-target toxicity, long processing time, limited efficacy, and extremely high cost. Bionanomaterials combined with these therapies address these issues by enhancing immune regulation, integrating the synergistic effects of different molecules, and, most importantly, targeting and manipulating immune cells within the tumor. In this review, we will summarize the most current researches on bionanomaterials for targeted regulation of tumor-associated macrophages, myeloid-derived suppressor cells, dendritic cells, T lymphocyte cells, and cancer-associated fibroblasts and summarize the prospects and challenges of cell-targeted therapy and clinical translational potential in a tumor immune microenvironment in cancer treatment. |
| format | Article |
| id | doaj-art-0db51214edde41098b33b9ed984c0168 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-0db51214edde41098b33b9ed984c01682025-02-03T01:28:29ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/66630356663035Application of Bionanomaterials in Tumor Immune Microenvironment TherapyJiawei Wang0Yan Bao1Yandan Yao2Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaBreast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, ChinaTargeted therapy for the cancer immune system has become a clinical reality with remarkable success. Immune checkpoint blockade therapy and chimeric antigen receptor T-cell (CAR-T) immunotherapy are clinically effective in a variety of cancers. However, the clinical utility of immunotherapy in cancer is limited by severe off-target toxicity, long processing time, limited efficacy, and extremely high cost. Bionanomaterials combined with these therapies address these issues by enhancing immune regulation, integrating the synergistic effects of different molecules, and, most importantly, targeting and manipulating immune cells within the tumor. In this review, we will summarize the most current researches on bionanomaterials for targeted regulation of tumor-associated macrophages, myeloid-derived suppressor cells, dendritic cells, T lymphocyte cells, and cancer-associated fibroblasts and summarize the prospects and challenges of cell-targeted therapy and clinical translational potential in a tumor immune microenvironment in cancer treatment.http://dx.doi.org/10.1155/2021/6663035 |
| spellingShingle | Jiawei Wang Yan Bao Yandan Yao Application of Bionanomaterials in Tumor Immune Microenvironment Therapy Journal of Immunology Research |
| title | Application of Bionanomaterials in Tumor Immune Microenvironment Therapy |
| title_full | Application of Bionanomaterials in Tumor Immune Microenvironment Therapy |
| title_fullStr | Application of Bionanomaterials in Tumor Immune Microenvironment Therapy |
| title_full_unstemmed | Application of Bionanomaterials in Tumor Immune Microenvironment Therapy |
| title_short | Application of Bionanomaterials in Tumor Immune Microenvironment Therapy |
| title_sort | application of bionanomaterials in tumor immune microenvironment therapy |
| url | http://dx.doi.org/10.1155/2021/6663035 |
| work_keys_str_mv | AT jiaweiwang applicationofbionanomaterialsintumorimmunemicroenvironmenttherapy AT yanbao applicationofbionanomaterialsintumorimmunemicroenvironmenttherapy AT yandanyao applicationofbionanomaterialsintumorimmunemicroenvironmenttherapy |