Prognostic factors and survival outcomes in patients with salivary duct carcinoma: a retrospective cohort study
Abstract Background Salivary duct carcinoma (SDC) is a highly aggressive salivary gland malignancy with poor prognosis. The aim was to investigate the prognostic factors and survival outcomes in a cohort of SDC patients. Materials and methods This study retrospectively analyzed the clinicopathologic...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12903-025-05427-2 |
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| author | Fei Chen Liangbo Li Jingqiao Tao Nenghao Jin Liwei Wang Liang Zhu Bo Qiao Lejun Xing Bo Wei Jingqiu Bu Haizhong Zhang |
| author_facet | Fei Chen Liangbo Li Jingqiao Tao Nenghao Jin Liwei Wang Liang Zhu Bo Qiao Lejun Xing Bo Wei Jingqiu Bu Haizhong Zhang |
| author_sort | Fei Chen |
| collection | DOAJ |
| description | Abstract Background Salivary duct carcinoma (SDC) is a highly aggressive salivary gland malignancy with poor prognosis. The aim was to investigate the prognostic factors and survival outcomes in a cohort of SDC patients. Materials and methods This study retrospectively analyzed the clinicopathological data of 61 SDC patients treated at the First Medical Center of the PLA General Hospital between January 2010 and December 2020. Univariate and multivariate Cox proportional hazards models were used to identify prognostic factors for overall survival (OS). Fine-Gray subdistribution hazard model was used to analyze prognostic factors for cancer-specific mortality. Results Of the 61 patients, the parotid gland was the most common primary site (70.5%). Lymph node and distant metastases were present in 35 (57.4%) and 23 (37.7%) patients, respectively. The 5-year and 3-year OS rates were 35.2% and59.7%. Multivariate analysis identified platelet count (HR 0.99, 95%CI 0.98–1.00, P = 0.011) and distant metastasis (HR 2.79, 95%CI 1.38–5.64, P = 0.004) as independent prognostic factors for OS. Lymph node metastasis (SHR = 2.18, 95%CI 1.05–4.52, P = 0.036), distant metastasis (SHR = 3.07, 95%CI 1.47–6.42, P = 0.003), and platelet count (SHR = 0.99, 95%CI 0.99–1.00, P = 0.041) were independent prognostic factors for cancer-specific mortality. Conclusions Distant metastasis and thrombocytopenia are important predictors of poor overall survival in SDC patients. These findings underscore the potential significance of incorporating hematological parameters and metastatic status into clinical decision-making to optimize risk stratification and personalized treatment strategies. |
| format | Article |
| id | doaj-art-0db3602b891642eea08b88d4cd61bdb7 |
| institution | Kabale University |
| issn | 1472-6831 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj-art-0db3602b891642eea08b88d4cd61bdb72025-01-19T12:41:07ZengBMCBMC Oral Health1472-68312025-01-012511910.1186/s12903-025-05427-2Prognostic factors and survival outcomes in patients with salivary duct carcinoma: a retrospective cohort studyFei Chen0Liangbo Li1Jingqiao Tao2Nenghao Jin3Liwei Wang4Liang Zhu5Bo Qiao6Lejun Xing7Bo Wei8Jingqiu Bu9Haizhong Zhang10Department of Stomatology, Chinese PLA General HospitalDepartment of Stomatology, Chinese PLA General HospitalDepartment of Stomatology, Southern Medical Branch of PLA General HospitalSchool of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua UniversityDepartment of Stomatology, Chinese PLA General HospitalDepartment of Stomatology, Chinese PLA General HospitalDepartment of Stomatology, Chinese PLA General HospitalDepartment of Stomatology, Chinese PLA General HospitalDepartment of Stomatology, Chinese PLA General HospitalDepartment of Stomatology, Chinese PLA General HospitalDepartment of Stomatology, Chinese PLA General HospitalAbstract Background Salivary duct carcinoma (SDC) is a highly aggressive salivary gland malignancy with poor prognosis. The aim was to investigate the prognostic factors and survival outcomes in a cohort of SDC patients. Materials and methods This study retrospectively analyzed the clinicopathological data of 61 SDC patients treated at the First Medical Center of the PLA General Hospital between January 2010 and December 2020. Univariate and multivariate Cox proportional hazards models were used to identify prognostic factors for overall survival (OS). Fine-Gray subdistribution hazard model was used to analyze prognostic factors for cancer-specific mortality. Results Of the 61 patients, the parotid gland was the most common primary site (70.5%). Lymph node and distant metastases were present in 35 (57.4%) and 23 (37.7%) patients, respectively. The 5-year and 3-year OS rates were 35.2% and59.7%. Multivariate analysis identified platelet count (HR 0.99, 95%CI 0.98–1.00, P = 0.011) and distant metastasis (HR 2.79, 95%CI 1.38–5.64, P = 0.004) as independent prognostic factors for OS. Lymph node metastasis (SHR = 2.18, 95%CI 1.05–4.52, P = 0.036), distant metastasis (SHR = 3.07, 95%CI 1.47–6.42, P = 0.003), and platelet count (SHR = 0.99, 95%CI 0.99–1.00, P = 0.041) were independent prognostic factors for cancer-specific mortality. Conclusions Distant metastasis and thrombocytopenia are important predictors of poor overall survival in SDC patients. These findings underscore the potential significance of incorporating hematological parameters and metastatic status into clinical decision-making to optimize risk stratification and personalized treatment strategies.https://doi.org/10.1186/s12903-025-05427-2Salivary duct carcinomaPrognosisSurvival |
| spellingShingle | Fei Chen Liangbo Li Jingqiao Tao Nenghao Jin Liwei Wang Liang Zhu Bo Qiao Lejun Xing Bo Wei Jingqiu Bu Haizhong Zhang Prognostic factors and survival outcomes in patients with salivary duct carcinoma: a retrospective cohort study BMC Oral Health Salivary duct carcinoma Prognosis Survival |
| title | Prognostic factors and survival outcomes in patients with salivary duct carcinoma: a retrospective cohort study |
| title_full | Prognostic factors and survival outcomes in patients with salivary duct carcinoma: a retrospective cohort study |
| title_fullStr | Prognostic factors and survival outcomes in patients with salivary duct carcinoma: a retrospective cohort study |
| title_full_unstemmed | Prognostic factors and survival outcomes in patients with salivary duct carcinoma: a retrospective cohort study |
| title_short | Prognostic factors and survival outcomes in patients with salivary duct carcinoma: a retrospective cohort study |
| title_sort | prognostic factors and survival outcomes in patients with salivary duct carcinoma a retrospective cohort study |
| topic | Salivary duct carcinoma Prognosis Survival |
| url | https://doi.org/10.1186/s12903-025-05427-2 |
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