Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans

Plasma levels of anti phosphocholine IgM antibodies are negatively correlated with bone mineral density in humans

Abstract Phosphatidylcholine is a ubiquitous phospholipid. It contains a phosphocholine (PC) headgroup and polyunsaturated fatty acids that, when oxidized, form reactive oxidized phospholipids (PC-OxPLs). PC-OxPLs are pathogenic in multiple diseases and neutralized by anti-PC IgM antibodies. The lev...

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Bibliographic Details
Main Authors: Michela Palmieri, Spyridoula Maraka, Horace J. Spencer, Jeff D. Thostenson, Katherine Dishongh, Micheal Knox, Betty Ussery, Jesse Byrd, Jacqueline K. Kuipers, Sanaz Abedzadeh-Anaraki, Chitharanjan Duvoor, Yuanjie Mao, Lakshmi Menon, James S. Williams, Stavros C. Manolagas, Robert L. Jilka, Elena Ambrogini
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Oxidized phospholipids
Anti-PC IgM antibodies
Bone mineral density
Online Access:https://doi.org/10.1038/s41598-025-85624-9
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