Disseminated histoplasmosis presenting as adrenal insufficiency: A case report
This report aims to highlight rarity of disseminated histoplasmosis (DH) presenting as adrenal insufficiency and the need for considering it in the differential diagnosis, even in non-endemic areas. A case is presented of a 69-year-old male patient with a background of hypertension and diabetes mell...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Medical Mycology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211753925000077 |
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| author | Md. Asaduzzaman Ranjon Kumer Roy Suchanda Roy Nasad Ahmed Sazeda Akter Monotush Ronjon Chando |
| author_facet | Md. Asaduzzaman Ranjon Kumer Roy Suchanda Roy Nasad Ahmed Sazeda Akter Monotush Ronjon Chando |
| author_sort | Md. Asaduzzaman |
| collection | DOAJ |
| description | This report aims to highlight rarity of disseminated histoplasmosis (DH) presenting as adrenal insufficiency and the need for considering it in the differential diagnosis, even in non-endemic areas. A case is presented of a 69-year-old male patient with a background of hypertension and diabetes mellitus, with a persistent fever, significant loss of weight, and general weakness. Imaging studies showed adrenal masses in both adrenal glands, and laboratory tests showed hyperkalemia and hyponatremia. Hormonal tests confirmed the diagnosis of adrenal insufficiency. CT-guided adrenal biopsy confirmed the diagnosis of histoplasmosis. The patient received a 14-day course of Amphotericin B, followed by oral Itraconazole and glucocorticoid substitution therapy, with improvement in adrenal function over a period of time. |
| format | Article |
| id | doaj-art-0da99ab6e5604c84bf178fa2fd2a8b04 |
| institution | DOAJ |
| issn | 2211-7539 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medical Mycology Case Reports |
| spelling | doaj-art-0da99ab6e5604c84bf178fa2fd2a8b042025-08-20T02:52:21ZengElsevierMedical Mycology Case Reports2211-75392025-03-014710069810.1016/j.mmcr.2025.100698Disseminated histoplasmosis presenting as adrenal insufficiency: A case reportMd. Asaduzzaman0Ranjon Kumer Roy1Suchanda Roy2Nasad Ahmed3Sazeda Akter4Monotush Ronjon Chando5Department of Medicine, Sylhet MAG Osmani Medical College Hospital, Sylhet, 3100, Bangladesh; Corresponding author. Sylhet MAG Osmani Medical College Hospital, Sylhet, 3100, Bangladesh.Department of Medicine, Sylhet MAG Osmani Medical College, Sylhet, 3100, BangladeshDepartment of Pathology, Jalalabad Ragib Rabeya Medical College & Hospital, Sylhet, BangladeshDepartment of Medicine, Shaheed Syed Nazrul Islam Medical College, Kishoreganj, BangladeshDepartment of Medicine, Sylhet MAG Osmani Medical College Hospital, Sylhet, 3100, BangladeshDepartment of Medicine, Sylhet MAG Osmani Medical College Hospital, Sylhet, 3100, BangladeshThis report aims to highlight rarity of disseminated histoplasmosis (DH) presenting as adrenal insufficiency and the need for considering it in the differential diagnosis, even in non-endemic areas. A case is presented of a 69-year-old male patient with a background of hypertension and diabetes mellitus, with a persistent fever, significant loss of weight, and general weakness. Imaging studies showed adrenal masses in both adrenal glands, and laboratory tests showed hyperkalemia and hyponatremia. Hormonal tests confirmed the diagnosis of adrenal insufficiency. CT-guided adrenal biopsy confirmed the diagnosis of histoplasmosis. The patient received a 14-day course of Amphotericin B, followed by oral Itraconazole and glucocorticoid substitution therapy, with improvement in adrenal function over a period of time.http://www.sciencedirect.com/science/article/pii/S2211753925000077Histoplasma capsulatumDisseminated histoplasmosisAdrenal insufficiencyNon-endemic area |
| spellingShingle | Md. Asaduzzaman Ranjon Kumer Roy Suchanda Roy Nasad Ahmed Sazeda Akter Monotush Ronjon Chando Disseminated histoplasmosis presenting as adrenal insufficiency: A case report Medical Mycology Case Reports Histoplasma capsulatum Disseminated histoplasmosis Adrenal insufficiency Non-endemic area |
| title | Disseminated histoplasmosis presenting as adrenal insufficiency: A case report |
| title_full | Disseminated histoplasmosis presenting as adrenal insufficiency: A case report |
| title_fullStr | Disseminated histoplasmosis presenting as adrenal insufficiency: A case report |
| title_full_unstemmed | Disseminated histoplasmosis presenting as adrenal insufficiency: A case report |
| title_short | Disseminated histoplasmosis presenting as adrenal insufficiency: A case report |
| title_sort | disseminated histoplasmosis presenting as adrenal insufficiency a case report |
| topic | Histoplasma capsulatum Disseminated histoplasmosis Adrenal insufficiency Non-endemic area |
| url | http://www.sciencedirect.com/science/article/pii/S2211753925000077 |
| work_keys_str_mv | AT mdasaduzzaman disseminatedhistoplasmosispresentingasadrenalinsufficiencyacasereport AT ranjonkumerroy disseminatedhistoplasmosispresentingasadrenalinsufficiencyacasereport AT suchandaroy disseminatedhistoplasmosispresentingasadrenalinsufficiencyacasereport AT nasadahmed disseminatedhistoplasmosispresentingasadrenalinsufficiencyacasereport AT sazedaakter disseminatedhistoplasmosispresentingasadrenalinsufficiencyacasereport AT monotushronjonchando disseminatedhistoplasmosispresentingasadrenalinsufficiencyacasereport |