4-Octyl Itaconate ameliorates diesel exhaust particle-induced oxidative stress in nasal epithelial cells

4-Octyl Itaconate ameliorates diesel exhaust particle-induced oxidative stress in nasal epithelial cells

Background and objectiveParticulate matters such as diesel exhaust particles induce oxidative stress in cells and thereby have a negative impact on health. The aim of this study was to test whether the membrane-permeable, anti-inflammatory metabolite 4-Octyl Itaconate can counteract the oxidative st...

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Bibliographic Details
Main Authors: Hanna Steppuhn, Katja Hohenberger, Susanne Mittler, Sonja Trump, Christine Carvalho, Manfred Rauh, Andreas B. Wild, Nikolaos G. Papadopoulos, Susetta Finotto
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
reactive oxygen species
itaconate
particulate matter
respiratory mucosa
RNA-seq analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1640499/full
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