A Pragmatic Approach to Handling Censored Data Below the Lower Limit of Quantification in Pharmacokinetic Modeling

A Pragmatic Approach to Handling Censored Data Below the Lower Limit of Quantification in Pharmacokinetic Modeling

ABSTRACT Proper handling of data below the lower limit of quantification (BLQ) is crucial for accurate pharmacokinetic parameter estimation. The M3 method proposed by Beal uses a likelihood‐based approach that is precise but has been reported to suffer from numerical issues in converging. Common alt...

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Bibliographic Details
Main Authors: Marie Wijk, Roeland E. Wasmann, Karen R. Jacobson, Elin M. Svensson, Paolo Denti
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Subjects:
censoring
likelihood
NONMEM
parameter estimation
population pharmacokinetics
Online Access:https://doi.org/10.1002/psp4.70015
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