Digoxin promotes anoikis of circulating cancer cells by targeting Na+/K+-ATPase α3-isoform

Digoxin promotes anoikis of circulating cancer cells by targeting Na+/K+-ATPase α3-isoform

Abstract Circulating cancer cells (CCCs) are closely related to the process of distant metastasis. In early step of the metastasis cascade, CCCs must evade the detachment-induced cell death (anoikis) for their survival. Here, we examined whether Na+/K+-ATPase α3-isoform (α3NaK) in CCCs contributes t...

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Main Authors: Yoshihisa Numata, Takuto Fujii, Chihiro Toda, Tomoyuki Okumura, Takahiro Manabe, Naoya Takeda, Takahiro Shimizu, Yoshiaki Tabuchi, Tsutomu Fujii, Hideki Sakai
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07703-z
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