Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives
A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obta...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2008.100 |
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| author | Elaine S. Coimbra Camila G. Almeida Wilson V. Júnior Roberta C. N. Dos Reis Ana C. F. De Almeida Luana S. M. Forezi Mauro V. De Almeida Mireille Le Hyaric |
| author_facet | Elaine S. Coimbra Camila G. Almeida Wilson V. Júnior Roberta C. N. Dos Reis Ana C. F. De Almeida Luana S. M. Forezi Mauro V. De Almeida Mireille Le Hyaric |
| author_sort | Elaine S. Coimbra |
| collection | DOAJ |
| description | A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obtained for compounds 10 and 15 with IC50 against L. chagasi below 5 μM. |
| format | Article |
| id | doaj-art-0d91b4a2ae48444d8c05d899142a056a |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-0d91b4a2ae48444d8c05d899142a056a2025-02-03T01:11:42ZengWileyThe Scientific World Journal1537-744X2008-01-01875275610.1100/tsw.2008.100Antileishmanial Activity of Aldonamides and N-Acyl-Diamine DerivativesElaine S. Coimbra0Camila G. Almeida1Wilson V. Júnior2Roberta C. N. Dos Reis3Ana C. F. De Almeida4Luana S. M. Forezi5Mauro V. De Almeida6Mireille Le Hyaric7Departamento de Parasitologia, Microbiologia e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora, Cidade Universitária, 36036-900, Juiz de Fora, MG, BrazilDepartamento de Quíca, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Cidade Universitária, 36036-900, Juiz de Fora, MG, BrazilDepartamento de Parasitologia, Microbiologia e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora, Cidade Universitária, 36036-900, Juiz de Fora, MG, BrazilDepartamento de Quíca, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Cidade Universitária, 36036-900, Juiz de Fora, MG, BrazilDepartamento de Parasitologia, Microbiologia e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora, Cidade Universitária, 36036-900, Juiz de Fora, MG, BrazilDepartamento de Quíca, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Cidade Universitária, 36036-900, Juiz de Fora, MG, BrazilDepartamento de Quíca, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Cidade Universitária, 36036-900, Juiz de Fora, MG, BrazilDepartamento de Quíca, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora, Cidade Universitária, 36036-900, Juiz de Fora, MG, BrazilA number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obtained for compounds 10 and 15 with IC50 against L. chagasi below 5 μM.http://dx.doi.org/10.1100/tsw.2008.100 |
| spellingShingle | Elaine S. Coimbra Camila G. Almeida Wilson V. Júnior Roberta C. N. Dos Reis Ana C. F. De Almeida Luana S. M. Forezi Mauro V. De Almeida Mireille Le Hyaric Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives The Scientific World Journal |
| title | Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives |
| title_full | Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives |
| title_fullStr | Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives |
| title_full_unstemmed | Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives |
| title_short | Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives |
| title_sort | antileishmanial activity of aldonamides and n acyl diamine derivatives |
| url | http://dx.doi.org/10.1100/tsw.2008.100 |
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