Developmental immune network of airway lymphocytes and innate immune cells in patients with stable COPD

Developmental immune network of airway lymphocytes and innate immune cells in patients with stable COPD

IntroductionChronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation and immune dysfunction. However, the molecular alterations and precise origins of immune cells in COPD airways remain poorly understood.MethodsHere, CD45+ immune cells in bronchoalveolar lavag...

Full description

Saved in:

Bibliographic Details
Main Authors:	Lanlan Liu, Mei Zhou, Shengwen Sun, Long Chen, Dehu Li, Jiaxi Lv, Rui Cheng, Jianchu Zhang, Jianghua Wu, Xianzhi Xiong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Series:	Frontiers in Immunology
Subjects:	chronic obstructive pulmonary disease single-cell RNA sequencing T cell exhaustion alveolar macrophages lipid metabolic reprogramming
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1614655/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Innate epithelial and functional differences in airway epithelium of children with acute wheeze
by: Kevin Looi, et al.
Published: (2025-07-01)

Innate immune recognition of Mycobacterium tuberculosis: receptor engagement and inflammatory outcomes at the site of infection
by: N.E. Mvubu
Published: (2025-12-01)

Deletion of CD38 enhances CD19 chimeric antigen receptor T cell function
by: Kimberly Veliz, et al.
Published: (2024-06-01)

The Clinical significance of Peripheral Blood-related Inflammatory Markers in patients with AECOPD
by: Dehu Li, et al.
Published: (2025-05-01)

CD155 as a therapeutic target in alveolar echinococcosis: insights from an Echinococcus multilocularis infection mouse model
by: Xue Zhang, et al.
Published: (2025-07-01)

Immune checkpoints in immune response to glioma: two sides of the same coin
by: Oxana Musatova, et al.
Published: (2025-08-01)

Metabolic checkpoints in immune cell reprogramming: rewiring immunometabolism for cancer therapy
by: Yingying Lv, et al.
Published: (2025-08-01)

Targeting alveolar epithelial cell metabolism in pulmonary fibrosis: Pioneering an emerging therapeutic strategy
by: Tengkun Dai, et al.
Published: (2025-06-01)

Targeting tumor metabolism to augment CD8+ T cell anti-tumor immunity
by: Huan Liu, et al.
Published: (2025-05-01)

Somatic cell reprogramming for Parkinson's disease treatment
by: Xiaozhuo Li, et al.
Published: (2025-03-01)

Ignoring Gender-Based Immunometabolic Reprograming, a Risky Business in Immune-Based Precision Medicine
by: Vijay Kumar
Published: (2025-01-01)

Harnessing innate immunity against glioblastoma microenvironment
by: Wenbo Zhang, et al.
Published: (2025-07-01)

Impacts of epigenetic reprogramming on innate immunity
by: Jie Fu, et al.
Published: (2024-01-01)

Research on strategies to inhibit CAR-T cell exhaustion
by: FU Qiongyu, HAO Xinbao, TAO Shi
Published: (2025-04-01)

The Immune Regulatory Mechanism of Adrenomedullin on Promoting the Proliferation and Differentiation of Dental Pulp Stem Cells
by: Yangpeng Zhao, et al.
Published: (2024-12-01)

Decoding the metabolic dialogue in the tumor microenvironment: from immune suppression to precision cancer therapies
by: Ruoli Wang, et al.
Published: (2025-07-01)

Bioinformatics-based analysis of the relationship between STC1 expression and immune infiltration in gastric cancer
by: Weijun Ma, et al.
Published: (2025-07-01)

Editorial: Methods in molecular innate immunity: 2022
by: Jörg H. Fritz, et al.
Published: (2025-02-01)

Amino acid metabolism-mediated immune cell fate and function in pigs
by: Liuqin He, et al.
Published: (2025-01-01)

Disulfidptosis as a key regulator of glioblastoma progression and immune cell impairment
by: Yifu Shu, et al.
Published: (2025-01-01)

Harnessing amino acid pathways to influence myeloid cell function in tumor immunity
by: Jiongli Pan, et al.
Published: (2025-02-01)

Editorial: Single-cell sequencing of the immune microenvironment in cancer
by: David G. Coffey
Published: (2025-07-01)

An atlas of immune cell exhaustion in HIV-infected individuals revealed by single-cell transcriptomics
by: Shaobo Wang, et al.
Published: (2020-01-01)

Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atrophic gastritis
by: Lin Lin, et al.
Published: (2025-02-01)

Influence of environmental exposures on T follicular helper cell function and implications on immunity: a comparison of Bangladeshi and American children
by: Dana M. Van Fossen, et al.
Published: (2025-04-01)

Innate immune training in the neonatal response to sepsis
by: Jaimar C. Rincon, et al.
Published: (2025-04-01)

Fine tuning of the innate and adaptive immune responses by Interleukin-2
by: Christina Sakellariou, et al.
Published: (2024-12-01)

The metabolism-immunity axis in Immune thrombocytopenia: from energy regulation to targeted therapy
by: Xin Zhou, et al.
Published: (2025-07-01)

Recent advances in the genetics and innate immune cells of bullous pemphigoid
by: Xiaoli Yang, et al.
Published: (2025-06-01)

Single-cell and spatial transcriptomics reveal a stress-induced EMT-like epithelial subset driving immune activation in silica-injured lung
by: Tao Wang, et al.
Published: (2025-06-01)

Patterns and Underlying Mechanisms of Airway Epithelial Cell Death in COPD
by: Ting Wang, et al.
Published: (2025-12-01)

Innate immune recognition in hepatitis B virus infection
by: Aixin Li, et al.
Published: (2025-12-01)

Targeting BATF2-RGS2 axis reduces T-cell exhaustion and restores anti-tumor immunity
by: Xuyu Gu, et al.
Published: (2025-05-01)

Intrinsic Immune Response of HBV/HDV-Infected Cells and Corresponding Innate (Like) Immune Cell Activation
by: Christopher Groth, et al.
Published: (2024-11-01)

Correction: Single-cell and spatial transcriptomics reveal a stress-induced EMT-like epithelial subset driving immune activation in silica-injured lung
by: Tao Wang, et al.
Published: (2025-08-01)

AAV-HBV mouse model replicates the intrahepatic immune landscape of chronic HBV patients at single-cell level
by: Nádia Conceição-Neto, et al.
Published: (2025-06-01)

Role of CD28+ PD-1+ Tc cells in immune response and prognosis prediction in hepatocellular carcinoma
by: Wuhan Yang, et al.
Published: (2025-06-01)

Thrombospondin-1 induces CD8+ T cell exhaustion and immune suppression within the tumor microenvironment of ovarian cancer
by: Haiyan Liang, et al.
Published: (2025-05-01)

CD39 dynamics in tuberculosis: a potential biomarker of immune dysregulation and T cell exhaustion
by: Ling Hao, et al.
Published: (2025-08-01)

The role of innate immune system in respiratory viral infection related asthma
by: Xiao Wu, et al.
Published: (2025-06-01)