Telomere Length in Elderly Caucasians Weakly Correlates with Blood Cell Counts
Background. Age-related decrease in bone marrow erythropoietic capacity is often accompanied by the telomere length shortening in peripheral white blood cells. However, limited and conflicting data hamper the conclusive opinion regarding this relationship. Therefore, the aim of this study was to ass...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/153608 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552479802261504 |
|---|---|
| author | Ewa Gutmajster Joanna Witecka Magdalena Wyskida Justyna Koscinska-Marczewska Malgorzata Szwed Magdalena Owczarz Malgorzata Mossakowska Andrzej Milewicz Monika Puzianowska-Kuznicka Jan Zejda Andrzej Wiecek Jerzy Chudek Aleksander L. Sieron |
| author_facet | Ewa Gutmajster Joanna Witecka Magdalena Wyskida Justyna Koscinska-Marczewska Malgorzata Szwed Magdalena Owczarz Malgorzata Mossakowska Andrzej Milewicz Monika Puzianowska-Kuznicka Jan Zejda Andrzej Wiecek Jerzy Chudek Aleksander L. Sieron |
| author_sort | Ewa Gutmajster |
| collection | DOAJ |
| description | Background. Age-related decrease in bone marrow erythropoietic capacity is often accompanied by the telomere length shortening in peripheral white blood cells. However, limited and conflicting data hamper the conclusive opinion regarding this relationship. Therefore, the aim of this study was to assess an association between telomere length and peripheral blood cell count parameters in the Polish elderly population. Material and Methods. The substudy included 1573 of 4981 subjects aged 65 years or over, participants of the population-based PolSenior study. High-molecular-weight DNA was isolated from blood mononuclear cells. Telomere length (TL) was measured by QRT-PCR as abundance of telomere template versus a single gene copy encoding acidic ribosomal phosphoprotein P0. Results. Only white blood count (WBC) was significantly different in TL tertile subgroups in all subjects (P=0.02) and in men (P=0.01), but not in women. Merely in men significant but weak positive correlations were found between TL and WBC (r=0.11, P<0.05) and RBC (r=0.08, P<0.05). The multiple regression analysis models confirmed a weak, independent contribution of TL to both RBC and WBC. Conclusions. In the elderly, telomere shortening limits hematopoiesis capacity to a very limited extent. |
| format | Article |
| id | doaj-art-0d79fbe483714fd1bed129e06ac95ee0 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-0d79fbe483714fd1bed129e06ac95ee02025-02-03T05:58:35ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/153608153608Telomere Length in Elderly Caucasians Weakly Correlates with Blood Cell CountsEwa Gutmajster0Joanna Witecka1Magdalena Wyskida2Justyna Koscinska-Marczewska3Malgorzata Szwed4Magdalena Owczarz5Malgorzata Mossakowska6Andrzej Milewicz7Monika Puzianowska-Kuznicka8Jan Zejda9Andrzej Wiecek10Jerzy Chudek11Aleksander L. Sieron12Department of General and Molecular Biology and Genetics, Medical University of Silesia, 40-752 Katowice, PolandDepartment of General and Molecular Biology and Genetics, Medical University of Silesia, 40-752 Katowice, PolandDepartment of General and Molecular Biology and Genetics, Medical University of Silesia, 40-752 Katowice, PolandDepartment of General and Molecular Biology and Genetics, Medical University of Silesia, 40-752 Katowice, PolandDepartment of Human Epigenetics, Mossakowski Medical Research Centre, 02-106 Warsaw, PolandDepartment of Human Epigenetics, Mossakowski Medical Research Centre, 02-106 Warsaw, PolandInternational Institute of Molecular and Cell Biology, 02-109 Warsaw, PolandDepartment of Endocrinology, Diabetology and Isotope Therapy Medical University, 50-367 Wroclaw, PolandDepartment of Human Epigenetics, Mossakowski Medical Research Centre, 02-106 Warsaw, PolandDepartment of Epidemiology, Medical University of Silesia, 40-752 Katowice, PolandDepartment of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, 40-027 Katowice, PolandDepartment of Pathophysiology, Medical University of Silesia, 40-752 Katowice, PolandDepartment of General and Molecular Biology and Genetics, Medical University of Silesia, 40-752 Katowice, PolandBackground. Age-related decrease in bone marrow erythropoietic capacity is often accompanied by the telomere length shortening in peripheral white blood cells. However, limited and conflicting data hamper the conclusive opinion regarding this relationship. Therefore, the aim of this study was to assess an association between telomere length and peripheral blood cell count parameters in the Polish elderly population. Material and Methods. The substudy included 1573 of 4981 subjects aged 65 years or over, participants of the population-based PolSenior study. High-molecular-weight DNA was isolated from blood mononuclear cells. Telomere length (TL) was measured by QRT-PCR as abundance of telomere template versus a single gene copy encoding acidic ribosomal phosphoprotein P0. Results. Only white blood count (WBC) was significantly different in TL tertile subgroups in all subjects (P=0.02) and in men (P=0.01), but not in women. Merely in men significant but weak positive correlations were found between TL and WBC (r=0.11, P<0.05) and RBC (r=0.08, P<0.05). The multiple regression analysis models confirmed a weak, independent contribution of TL to both RBC and WBC. Conclusions. In the elderly, telomere shortening limits hematopoiesis capacity to a very limited extent.http://dx.doi.org/10.1155/2013/153608 |
| spellingShingle | Ewa Gutmajster Joanna Witecka Magdalena Wyskida Justyna Koscinska-Marczewska Malgorzata Szwed Magdalena Owczarz Malgorzata Mossakowska Andrzej Milewicz Monika Puzianowska-Kuznicka Jan Zejda Andrzej Wiecek Jerzy Chudek Aleksander L. Sieron Telomere Length in Elderly Caucasians Weakly Correlates with Blood Cell Counts The Scientific World Journal |
| title | Telomere Length in Elderly Caucasians Weakly Correlates with Blood Cell Counts |
| title_full | Telomere Length in Elderly Caucasians Weakly Correlates with Blood Cell Counts |
| title_fullStr | Telomere Length in Elderly Caucasians Weakly Correlates with Blood Cell Counts |
| title_full_unstemmed | Telomere Length in Elderly Caucasians Weakly Correlates with Blood Cell Counts |
| title_short | Telomere Length in Elderly Caucasians Weakly Correlates with Blood Cell Counts |
| title_sort | telomere length in elderly caucasians weakly correlates with blood cell counts |
| url | http://dx.doi.org/10.1155/2013/153608 |
| work_keys_str_mv | AT ewagutmajster telomerelengthinelderlycaucasiansweaklycorrelateswithbloodcellcounts AT joannawitecka telomerelengthinelderlycaucasiansweaklycorrelateswithbloodcellcounts AT magdalenawyskida telomerelengthinelderlycaucasiansweaklycorrelateswithbloodcellcounts AT justynakoscinskamarczewska telomerelengthinelderlycaucasiansweaklycorrelateswithbloodcellcounts AT malgorzataszwed telomerelengthinelderlycaucasiansweaklycorrelateswithbloodcellcounts AT magdalenaowczarz telomerelengthinelderlycaucasiansweaklycorrelateswithbloodcellcounts AT malgorzatamossakowska telomerelengthinelderlycaucasiansweaklycorrelateswithbloodcellcounts AT andrzejmilewicz telomerelengthinelderlycaucasiansweaklycorrelateswithbloodcellcounts AT monikapuzianowskakuznicka telomerelengthinelderlycaucasiansweaklycorrelateswithbloodcellcounts AT janzejda telomerelengthinelderlycaucasiansweaklycorrelateswithbloodcellcounts AT andrzejwiecek telomerelengthinelderlycaucasiansweaklycorrelateswithbloodcellcounts AT jerzychudek telomerelengthinelderlycaucasiansweaklycorrelateswithbloodcellcounts AT aleksanderlsieron telomerelengthinelderlycaucasiansweaklycorrelateswithbloodcellcounts |