Advanced Epithelioid Malignant Peripheral Nerve Sheath Tumor Showing Complete Response to Combined Surgery and Chemotherapy: A Case Report
Malignant peripheral nerve sheath tumor (MPNST) is a rare high-grade soft tissue sarcoma. The epithelioid variant accounts for 5% or less of MPNSTs; the clinical behavior of this variant is unclear. Reports of approximately 40 cases are available in the English literature; however, most reports addr...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/705345 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546506896310272 |
|---|---|
| author | Tomohiro Minagawa Ryuta Shioya Chigusa Sato Ryuji Shichinohe Go Yasui Kohsuke Ishikawa Hiroko Takahashi |
| author_facet | Tomohiro Minagawa Ryuta Shioya Chigusa Sato Ryuji Shichinohe Go Yasui Kohsuke Ishikawa Hiroko Takahashi |
| author_sort | Tomohiro Minagawa |
| collection | DOAJ |
| description | Malignant peripheral nerve sheath tumor (MPNST) is a rare high-grade soft tissue sarcoma. The epithelioid variant accounts for 5% or less of MPNSTs; the clinical behavior of this variant is unclear. Reports of approximately 40 cases are available in the English literature; however, most reports addressed clinicopathological features rather than therapeutic procedures or clinical courses.
We describe a case of a 62-year-old male with an epithelioid MPNST of the left foot. Multiple lung metastases developed after radical surgery on the primary lesion. The response to adjuvant chemotherapy including doxorubicin and ifosfamide was favorable, and thoracoscopic resection was subsequently performed on the remaining three metastases. No evidence of recurrence or metastasis was observed at the 12-month followup after the first operation. Further followup and chemotherapy may be required. |
| format | Article |
| id | doaj-art-0d78f34bed5e44d990a4e384dc40c87a |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-0d78f34bed5e44d990a4e384dc40c87a2025-02-03T06:48:17ZengWileyCase Reports in Oncological Medicine2090-67062090-67142011-01-01201110.1155/2011/705345705345Advanced Epithelioid Malignant Peripheral Nerve Sheath Tumor Showing Complete Response to Combined Surgery and Chemotherapy: A Case ReportTomohiro Minagawa0Ryuta Shioya1Chigusa Sato2Ryuji Shichinohe3Go Yasui4Kohsuke Ishikawa5Hiroko Takahashi6Department of Plastic and Reconstructive Surgery, Asahikawa-Kosei General Hospital, 1 Jo-dohri 24-chome 111, Asahikawa City, Hokkaido 078-8211, JapanDepartment of Plastic and Reconstructive Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-0815, JapanDepartment of Plastic and Reconstructive Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-0815, JapanDepartment of Plastic and Reconstructive Surgery, Asahikawa-Kosei General Hospital, 1 Jo-dohri 24-chome 111, Asahikawa City, Hokkaido 078-8211, JapanDepartment of Plastic and Reconstructive Surgery, Asahikawa-Kosei General Hospital, 1 Jo-dohri 24-chome 111, Asahikawa City, Hokkaido 078-8211, JapanDepartment of Plastic and Reconstructive Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-0815, JapanDepartment of Plastic and Reconstructive Surgery, Asahikawa-Kosei General Hospital, 1 Jo-dohri 24-chome 111, Asahikawa City, Hokkaido 078-8211, JapanMalignant peripheral nerve sheath tumor (MPNST) is a rare high-grade soft tissue sarcoma. The epithelioid variant accounts for 5% or less of MPNSTs; the clinical behavior of this variant is unclear. Reports of approximately 40 cases are available in the English literature; however, most reports addressed clinicopathological features rather than therapeutic procedures or clinical courses. We describe a case of a 62-year-old male with an epithelioid MPNST of the left foot. Multiple lung metastases developed after radical surgery on the primary lesion. The response to adjuvant chemotherapy including doxorubicin and ifosfamide was favorable, and thoracoscopic resection was subsequently performed on the remaining three metastases. No evidence of recurrence or metastasis was observed at the 12-month followup after the first operation. Further followup and chemotherapy may be required.http://dx.doi.org/10.1155/2011/705345 |
| spellingShingle | Tomohiro Minagawa Ryuta Shioya Chigusa Sato Ryuji Shichinohe Go Yasui Kohsuke Ishikawa Hiroko Takahashi Advanced Epithelioid Malignant Peripheral Nerve Sheath Tumor Showing Complete Response to Combined Surgery and Chemotherapy: A Case Report Case Reports in Oncological Medicine |
| title | Advanced Epithelioid Malignant Peripheral Nerve Sheath Tumor Showing Complete Response to Combined Surgery and Chemotherapy: A Case Report |
| title_full | Advanced Epithelioid Malignant Peripheral Nerve Sheath Tumor Showing Complete Response to Combined Surgery and Chemotherapy: A Case Report |
| title_fullStr | Advanced Epithelioid Malignant Peripheral Nerve Sheath Tumor Showing Complete Response to Combined Surgery and Chemotherapy: A Case Report |
| title_full_unstemmed | Advanced Epithelioid Malignant Peripheral Nerve Sheath Tumor Showing Complete Response to Combined Surgery and Chemotherapy: A Case Report |
| title_short | Advanced Epithelioid Malignant Peripheral Nerve Sheath Tumor Showing Complete Response to Combined Surgery and Chemotherapy: A Case Report |
| title_sort | advanced epithelioid malignant peripheral nerve sheath tumor showing complete response to combined surgery and chemotherapy a case report |
| url | http://dx.doi.org/10.1155/2011/705345 |
| work_keys_str_mv | AT tomohirominagawa advancedepithelioidmalignantperipheralnervesheathtumorshowingcompleteresponsetocombinedsurgeryandchemotherapyacasereport AT ryutashioya advancedepithelioidmalignantperipheralnervesheathtumorshowingcompleteresponsetocombinedsurgeryandchemotherapyacasereport AT chigusasato advancedepithelioidmalignantperipheralnervesheathtumorshowingcompleteresponsetocombinedsurgeryandchemotherapyacasereport AT ryujishichinohe advancedepithelioidmalignantperipheralnervesheathtumorshowingcompleteresponsetocombinedsurgeryandchemotherapyacasereport AT goyasui advancedepithelioidmalignantperipheralnervesheathtumorshowingcompleteresponsetocombinedsurgeryandchemotherapyacasereport AT kohsukeishikawa advancedepithelioidmalignantperipheralnervesheathtumorshowingcompleteresponsetocombinedsurgeryandchemotherapyacasereport AT hirokotakahashi advancedepithelioidmalignantperipheralnervesheathtumorshowingcompleteresponsetocombinedsurgeryandchemotherapyacasereport |