Pentraxin 3 Is a Predictor for Fibrosis and Arterial Stiffness in Patients with Nonalcoholic Fatty Liver Disease
Objective. The aim of the present study was to investigate whether pentraxin 3 (PTX3) can be a new noninvasive marker for prediction of liver fibrosis in patients with NAFLD. We also aimed to evaluate the relationship between PTX3 and atherosclerosis in patients with NAFLD. Method. Fifty-four male p...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/1417962 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550675112787968 |
|---|---|
| author | Kadir Ozturk Omer Kurt Tolga Dogan Alptug Ozen Hakan Demirci Fatih Yesildal Murat Kantarcioglu Turker Turker Ahmet Kerem Guler Yıldırım Karslioglu Battal Altun Ahmet Uygun Sait Bagci |
| author_facet | Kadir Ozturk Omer Kurt Tolga Dogan Alptug Ozen Hakan Demirci Fatih Yesildal Murat Kantarcioglu Turker Turker Ahmet Kerem Guler Yıldırım Karslioglu Battal Altun Ahmet Uygun Sait Bagci |
| author_sort | Kadir Ozturk |
| collection | DOAJ |
| description | Objective. The aim of the present study was to investigate whether pentraxin 3 (PTX3) can be a new noninvasive marker for prediction of liver fibrosis in patients with NAFLD. We also aimed to evaluate the relationship between PTX3 and atherosclerosis in patients with NAFLD. Method. Fifty-four male patients with biopsy-proven NAFLD and 20 apparently healthy male volunteers were included. PTX3 levels were determined, using an ELISA method (R&D Sysytems, Quantikine ELISA, USA). To detect the presence of subclinical atherosclerosis in NAFLD, measurements of CIMT, FMD, and cf-PWV levels were performed. Results. PTX3 levels in NAFLD patients with fibrosis were higher than both NAFLD patients without fibrosis and controls (P=0.032 and P=0.028, respectively), but there was no difference between controls and NAFLD patients without fibrosis in terms of PTX3 levels (P=0.903). PTX3 levels were strongly correlated with cf-PWV (r=0.359, P=0.003), whereas no significant correlation was found with other atherosclerosis markers, CIMT and FMD. Conclusion. Elevated plasma PTX3 levels are associated with the presence of fibrosis in patients with NAFLD, independently of metabolic syndrome components. This study demonstrated that for the first time there is a close association between elevated PTX3 levels and increased arterial stiffness in patients with NAFLD. |
| format | Article |
| id | doaj-art-0d67fde746c94badb60fc1f5cb49d9da |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-0d67fde746c94badb60fc1f5cb49d9da2025-02-03T06:06:10ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/14179621417962Pentraxin 3 Is a Predictor for Fibrosis and Arterial Stiffness in Patients with Nonalcoholic Fatty Liver DiseaseKadir Ozturk0Omer Kurt1Tolga Dogan2Alptug Ozen3Hakan Demirci4Fatih Yesildal5Murat Kantarcioglu6Turker Turker7Ahmet Kerem Guler8Yıldırım Karslioglu9Battal Altun10Ahmet Uygun11Sait Bagci12Department of Gastroenterology, Gulhane School of Medicine, 06010 Ankara, TurkeyDepartment of Gastroenterology, Gulhane School of Medicine, 06010 Ankara, TurkeyDepartment of Internal Medicine, Gulhane School of Medicine, 06010 Ankara, TurkeyDepartment of Radiology, Gulhane School of Medicine, 06010 Ankara, TurkeyDepartment of Gastroenterology, Gulhane School of Medicine, 06010 Ankara, TurkeyDepartment of Medical Biochemistry, Gulhane School of Medicine, 06010 Ankara, TurkeyDepartment of Gastroenterology, Gulhane School of Medicine, 06010 Ankara, TurkeyDepartment of Health Public and Epidemiology, Gulhane School of Medicine, 06010 Ankara, TurkeyDepartment of Internal Medicine, Gulhane School of Medicine, 06010 Ankara, TurkeyDepartment of Pathology, Gulhane School of Medicine, 06010 Ankara, TurkeyDepartment of Internal Medicine, Kasımpasa Military Hospital, Istanbul, TurkeyDepartment of Gastroenterology, Gulhane School of Medicine, 06010 Ankara, TurkeyDepartment of Gastroenterology, Gulhane School of Medicine, 06010 Ankara, TurkeyObjective. The aim of the present study was to investigate whether pentraxin 3 (PTX3) can be a new noninvasive marker for prediction of liver fibrosis in patients with NAFLD. We also aimed to evaluate the relationship between PTX3 and atherosclerosis in patients with NAFLD. Method. Fifty-four male patients with biopsy-proven NAFLD and 20 apparently healthy male volunteers were included. PTX3 levels were determined, using an ELISA method (R&D Sysytems, Quantikine ELISA, USA). To detect the presence of subclinical atherosclerosis in NAFLD, measurements of CIMT, FMD, and cf-PWV levels were performed. Results. PTX3 levels in NAFLD patients with fibrosis were higher than both NAFLD patients without fibrosis and controls (P=0.032 and P=0.028, respectively), but there was no difference between controls and NAFLD patients without fibrosis in terms of PTX3 levels (P=0.903). PTX3 levels were strongly correlated with cf-PWV (r=0.359, P=0.003), whereas no significant correlation was found with other atherosclerosis markers, CIMT and FMD. Conclusion. Elevated plasma PTX3 levels are associated with the presence of fibrosis in patients with NAFLD, independently of metabolic syndrome components. This study demonstrated that for the first time there is a close association between elevated PTX3 levels and increased arterial stiffness in patients with NAFLD.http://dx.doi.org/10.1155/2016/1417962 |
| spellingShingle | Kadir Ozturk Omer Kurt Tolga Dogan Alptug Ozen Hakan Demirci Fatih Yesildal Murat Kantarcioglu Turker Turker Ahmet Kerem Guler Yıldırım Karslioglu Battal Altun Ahmet Uygun Sait Bagci Pentraxin 3 Is a Predictor for Fibrosis and Arterial Stiffness in Patients with Nonalcoholic Fatty Liver Disease Gastroenterology Research and Practice |
| title | Pentraxin 3 Is a Predictor for Fibrosis and Arterial Stiffness in Patients with Nonalcoholic Fatty Liver Disease |
| title_full | Pentraxin 3 Is a Predictor for Fibrosis and Arterial Stiffness in Patients with Nonalcoholic Fatty Liver Disease |
| title_fullStr | Pentraxin 3 Is a Predictor for Fibrosis and Arterial Stiffness in Patients with Nonalcoholic Fatty Liver Disease |
| title_full_unstemmed | Pentraxin 3 Is a Predictor for Fibrosis and Arterial Stiffness in Patients with Nonalcoholic Fatty Liver Disease |
| title_short | Pentraxin 3 Is a Predictor for Fibrosis and Arterial Stiffness in Patients with Nonalcoholic Fatty Liver Disease |
| title_sort | pentraxin 3 is a predictor for fibrosis and arterial stiffness in patients with nonalcoholic fatty liver disease |
| url | http://dx.doi.org/10.1155/2016/1417962 |
| work_keys_str_mv | AT kadirozturk pentraxin3isapredictorforfibrosisandarterialstiffnessinpatientswithnonalcoholicfattyliverdisease AT omerkurt pentraxin3isapredictorforfibrosisandarterialstiffnessinpatientswithnonalcoholicfattyliverdisease AT tolgadogan pentraxin3isapredictorforfibrosisandarterialstiffnessinpatientswithnonalcoholicfattyliverdisease AT alptugozen pentraxin3isapredictorforfibrosisandarterialstiffnessinpatientswithnonalcoholicfattyliverdisease AT hakandemirci pentraxin3isapredictorforfibrosisandarterialstiffnessinpatientswithnonalcoholicfattyliverdisease AT fatihyesildal pentraxin3isapredictorforfibrosisandarterialstiffnessinpatientswithnonalcoholicfattyliverdisease AT muratkantarcioglu pentraxin3isapredictorforfibrosisandarterialstiffnessinpatientswithnonalcoholicfattyliverdisease AT turkerturker pentraxin3isapredictorforfibrosisandarterialstiffnessinpatientswithnonalcoholicfattyliverdisease AT ahmetkeremguler pentraxin3isapredictorforfibrosisandarterialstiffnessinpatientswithnonalcoholicfattyliverdisease AT yıldırımkarslioglu pentraxin3isapredictorforfibrosisandarterialstiffnessinpatientswithnonalcoholicfattyliverdisease AT battalaltun pentraxin3isapredictorforfibrosisandarterialstiffnessinpatientswithnonalcoholicfattyliverdisease AT ahmetuygun pentraxin3isapredictorforfibrosisandarterialstiffnessinpatientswithnonalcoholicfattyliverdisease AT saitbagci pentraxin3isapredictorforfibrosisandarterialstiffnessinpatientswithnonalcoholicfattyliverdisease |