The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey)
Background. Two adjacent regions upstream CDKN2B on chromosome 9p21 have been associated with type 2 diabetes (T2D) and progression of cardiovascular disease (CVD). The precise location and number of risk variants have not been completely delineated and a possible synergistic relationship between th...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/164652 |
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| author | Øyvind Helgeland Jens K. Hertel Anders Molven Helge Ræder Carl G. P. Platou Kristian Midthjell Kristian Hveem Ottar Nygård Pål R. Njølstad Stefan Johansson |
| author_facet | Øyvind Helgeland Jens K. Hertel Anders Molven Helge Ræder Carl G. P. Platou Kristian Midthjell Kristian Hveem Ottar Nygård Pål R. Njølstad Stefan Johansson |
| author_sort | Øyvind Helgeland |
| collection | DOAJ |
| description | Background. Two adjacent regions upstream CDKN2B on chromosome 9p21 have been associated with type 2 diabetes (T2D) and progression of cardiovascular disease (CVD). The precise location and number of risk variants have not been completely delineated and a possible synergistic relationship between the adjacent regions is not fully addressed. By a population based cross-sectional case-control design, we genotyped 18 SNPs upstream of CDKN2B tagging 138 kb in and around two LD-blocks associated with CVD and T2D and investigated associations with T2D, angina pectoris (AP), myocardial infarction (MI), coronary heart disease (CHD; AP or AMI), and stroke using 5,564 subjects from HUNT2. Results. Single point and haplotype analysis showed evidence for only one common T2D risk haplotype (rs10757282∣rs10811661: OR = 1.19, P=2.0×10-3) in the region. We confirmed the strong association between SNPs in the 60 kb CVD region with AP, MI, and CHD (P<0.01). Conditioning on the lead SNPs in the region, we observed two suggestive independent single SNP association signals for MI, rs2065501 (P=0.03) and rs3217986 (P=0.04). Conclusions. We confirmed the association of known variants within the 9p21 interval with T2D and CHD. Our results further suggest that additional CHD susceptibility variants exist in this region. |
| format | Article |
| id | doaj-art-0d6753327b3b4286a3c7d0fec27c9639 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-0d6753327b3b4286a3c7d0fec27c96392025-02-03T01:21:14ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/164652164652The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey)Øyvind Helgeland0Jens K. Hertel1Anders Molven2Helge Ræder3Carl G. P. Platou4Kristian Midthjell5Kristian Hveem6Ottar Nygård7Pål R. Njølstad8Stefan Johansson9KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5021 Bergen, NorwayKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5021 Bergen, NorwayKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5021 Bergen, NorwayKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5021 Bergen, NorwayHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, NorwayHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, NorwayHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, NorwayKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5021 Bergen, NorwayKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5021 Bergen, NorwayKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5021 Bergen, NorwayBackground. Two adjacent regions upstream CDKN2B on chromosome 9p21 have been associated with type 2 diabetes (T2D) and progression of cardiovascular disease (CVD). The precise location and number of risk variants have not been completely delineated and a possible synergistic relationship between the adjacent regions is not fully addressed. By a population based cross-sectional case-control design, we genotyped 18 SNPs upstream of CDKN2B tagging 138 kb in and around two LD-blocks associated with CVD and T2D and investigated associations with T2D, angina pectoris (AP), myocardial infarction (MI), coronary heart disease (CHD; AP or AMI), and stroke using 5,564 subjects from HUNT2. Results. Single point and haplotype analysis showed evidence for only one common T2D risk haplotype (rs10757282∣rs10811661: OR = 1.19, P=2.0×10-3) in the region. We confirmed the strong association between SNPs in the 60 kb CVD region with AP, MI, and CHD (P<0.01). Conditioning on the lead SNPs in the region, we observed two suggestive independent single SNP association signals for MI, rs2065501 (P=0.03) and rs3217986 (P=0.04). Conclusions. We confirmed the association of known variants within the 9p21 interval with T2D and CHD. Our results further suggest that additional CHD susceptibility variants exist in this region.http://dx.doi.org/10.1155/2015/164652 |
| spellingShingle | Øyvind Helgeland Jens K. Hertel Anders Molven Helge Ræder Carl G. P. Platou Kristian Midthjell Kristian Hveem Ottar Nygård Pål R. Njølstad Stefan Johansson The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey) International Journal of Endocrinology |
| title | The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey) |
| title_full | The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey) |
| title_fullStr | The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey) |
| title_full_unstemmed | The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey) |
| title_short | The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey) |
| title_sort | chromosome 9p21 cvd and t2d associated regions in a norwegian population the hunt2 survey |
| url | http://dx.doi.org/10.1155/2015/164652 |
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