Potentials and Limitations of Real-Time Elastography for Prostate Cancer Detection: A Whole-Mount Step Section Analysis
Objectives. To evaluate prostate cancer (PCa) detection rates of real-time elastography (RTE) in dependence of tumor size, tumor volume, localization and histological type. Materials and Methods. Thirdy-nine patients with biopsy proven PCa underwent RTE before radical prostatectomy (RPE) to assess p...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/193213 |
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| author | Daniel Junker Georg Schäfer Friedrich Aigner Peter Schullian Leo Pallwein-Prettner Jasmin Bektic Wolfgang Horninger Ethan J. Halpern Ferdinand Frauscher |
| author_facet | Daniel Junker Georg Schäfer Friedrich Aigner Peter Schullian Leo Pallwein-Prettner Jasmin Bektic Wolfgang Horninger Ethan J. Halpern Ferdinand Frauscher |
| author_sort | Daniel Junker |
| collection | DOAJ |
| description | Objectives. To evaluate prostate cancer (PCa) detection rates of real-time elastography (RTE) in dependence of tumor size, tumor volume, localization and histological type. Materials and Methods. Thirdy-nine patients with biopsy proven PCa underwent RTE before radical prostatectomy (RPE) to assess prostate tissue elasticity, and hard lesions were considered suspicious for PCa. After RPE, the prostates were prepared as whole-mount step sections and were compared with imaging findings for analyzing PCa detection rates. Results. RTE detected 6/62 cancer lesions with a maximum diameter of 0–5 mm (9.7%), 10/37 with a maximum diameter of 6–10 mm (27%), 24/34 with a maximum diameter of 11–20 20 mm (70.6%), 14/14 with a maximum diameter of >20 mm (100%) and 40/48 with a volume ≥0.2 cm3 (83.3%). Regarding cancer lesions with a volume ≥ 0.2 cm³ there was a significant difference in PCa detection rates between Gleason scores with predominant Gleason pattern 3 compared to those with predominant Gleason pattern 4 or 5 (75% versus 100%; P=0.028). Conclusions. RTE is able to detect PCa of significant tumor volume and of predominant Gleason pattern 4 or 5 with high confidence, but is of limited value in the detection of small cancer lesions. |
| format | Article |
| id | doaj-art-0d60acdda97b42ed8eab43c0f2671c81 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-0d60acdda97b42ed8eab43c0f2671c812025-02-03T01:10:28ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/193213193213Potentials and Limitations of Real-Time Elastography for Prostate Cancer Detection: A Whole-Mount Step Section AnalysisDaniel Junker0Georg Schäfer1Friedrich Aigner2Peter Schullian3Leo Pallwein-Prettner4Jasmin Bektic5Wolfgang Horninger6Ethan J. Halpern7Ferdinand Frauscher8Department of Radiology, Medical University of Innsbruck, Anichstraß 35, 6020 Innsbruck, AustriaDepartment of Pathology, Medical University of Innsbruck, Anichstraß 35, 6020 Innsbruck, AustriaDepartment of Radiology, Medical University of Innsbruck, Anichstraß 35, 6020 Innsbruck, AustriaDepartment of Radiology, Medical University of Innsbruck, Anichstraß 35, 6020 Innsbruck, AustriaDepartment of Radiology, Hospital of the Sisters of Charity, 4020 Linz, AustriaDepartment of Urology, Medical University of Innsbruck, Anichstraß 35, 6020 Innsbruck, AustriaDepartment of Urology, Medical University of Innsbruck, Anichstraß 35, 6020 Innsbruck, AustriaThomas Jefferson Prostate Diagnostic Center, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Radiology, Medical University of Innsbruck, Anichstraß 35, 6020 Innsbruck, AustriaObjectives. To evaluate prostate cancer (PCa) detection rates of real-time elastography (RTE) in dependence of tumor size, tumor volume, localization and histological type. Materials and Methods. Thirdy-nine patients with biopsy proven PCa underwent RTE before radical prostatectomy (RPE) to assess prostate tissue elasticity, and hard lesions were considered suspicious for PCa. After RPE, the prostates were prepared as whole-mount step sections and were compared with imaging findings for analyzing PCa detection rates. Results. RTE detected 6/62 cancer lesions with a maximum diameter of 0–5 mm (9.7%), 10/37 with a maximum diameter of 6–10 mm (27%), 24/34 with a maximum diameter of 11–20 20 mm (70.6%), 14/14 with a maximum diameter of >20 mm (100%) and 40/48 with a volume ≥0.2 cm3 (83.3%). Regarding cancer lesions with a volume ≥ 0.2 cm³ there was a significant difference in PCa detection rates between Gleason scores with predominant Gleason pattern 3 compared to those with predominant Gleason pattern 4 or 5 (75% versus 100%; P=0.028). Conclusions. RTE is able to detect PCa of significant tumor volume and of predominant Gleason pattern 4 or 5 with high confidence, but is of limited value in the detection of small cancer lesions.http://dx.doi.org/10.1100/2012/193213 |
| spellingShingle | Daniel Junker Georg Schäfer Friedrich Aigner Peter Schullian Leo Pallwein-Prettner Jasmin Bektic Wolfgang Horninger Ethan J. Halpern Ferdinand Frauscher Potentials and Limitations of Real-Time Elastography for Prostate Cancer Detection: A Whole-Mount Step Section Analysis The Scientific World Journal |
| title | Potentials and Limitations of Real-Time Elastography for Prostate Cancer Detection: A Whole-Mount Step Section Analysis |
| title_full | Potentials and Limitations of Real-Time Elastography for Prostate Cancer Detection: A Whole-Mount Step Section Analysis |
| title_fullStr | Potentials and Limitations of Real-Time Elastography for Prostate Cancer Detection: A Whole-Mount Step Section Analysis |
| title_full_unstemmed | Potentials and Limitations of Real-Time Elastography for Prostate Cancer Detection: A Whole-Mount Step Section Analysis |
| title_short | Potentials and Limitations of Real-Time Elastography for Prostate Cancer Detection: A Whole-Mount Step Section Analysis |
| title_sort | potentials and limitations of real time elastography for prostate cancer detection a whole mount step section analysis |
| url | http://dx.doi.org/10.1100/2012/193213 |
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