Evaluation of In Vitro Anti-inflammatory Activity of Azomethines of Aryl Oxazoles
Ability to inhibit erythrocyte hemolysis is often used as a characteristic of the membrane stabilising action of chemical compounds. Azomethines of aryl oxazoles were evaluated for anti-inflammatory by in vitro hemolytic membrane stabilising study. The effect of inflammation condition was studied on...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/561759 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565074646007808 |
|---|---|
| author | V. Niraimathi A. Jerad Suresh T. Latha |
| author_facet | V. Niraimathi A. Jerad Suresh T. Latha |
| author_sort | V. Niraimathi |
| collection | DOAJ |
| description | Ability to inhibit erythrocyte hemolysis is often used as a characteristic of the membrane stabilising action of chemical compounds. Azomethines of aryl oxazoles were evaluated for anti-inflammatory by in vitro hemolytic membrane stabilising study. The effect of inflammation condition was studied on erythrocyte exposed to hypotonic solution. In this in vitro method the membrane stabilising action leads to anti-inflammatory activity and was compared with that produced by diclofenac sodium as the reference standard. Results of the evaluation indicate that the synthesised compounds found to exhibit membrane stabilising activity. |
| format | Article |
| id | doaj-art-0d5d105384b6490b82e22e028d17aa28 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-0d5d105384b6490b82e22e028d17aa282025-02-03T01:09:27ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-018S1S392S39410.1155/2011/561759Evaluation of In Vitro Anti-inflammatory Activity of Azomethines of Aryl OxazolesV. Niraimathi0A. Jerad Suresh1T. Latha2Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, IndiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, IndiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, IndiaAbility to inhibit erythrocyte hemolysis is often used as a characteristic of the membrane stabilising action of chemical compounds. Azomethines of aryl oxazoles were evaluated for anti-inflammatory by in vitro hemolytic membrane stabilising study. The effect of inflammation condition was studied on erythrocyte exposed to hypotonic solution. In this in vitro method the membrane stabilising action leads to anti-inflammatory activity and was compared with that produced by diclofenac sodium as the reference standard. Results of the evaluation indicate that the synthesised compounds found to exhibit membrane stabilising activity.http://dx.doi.org/10.1155/2011/561759 |
| spellingShingle | V. Niraimathi A. Jerad Suresh T. Latha Evaluation of In Vitro Anti-inflammatory Activity of Azomethines of Aryl Oxazoles E-Journal of Chemistry |
| title | Evaluation of In Vitro Anti-inflammatory Activity of Azomethines of Aryl Oxazoles |
| title_full | Evaluation of In Vitro Anti-inflammatory Activity of Azomethines of Aryl Oxazoles |
| title_fullStr | Evaluation of In Vitro Anti-inflammatory Activity of Azomethines of Aryl Oxazoles |
| title_full_unstemmed | Evaluation of In Vitro Anti-inflammatory Activity of Azomethines of Aryl Oxazoles |
| title_short | Evaluation of In Vitro Anti-inflammatory Activity of Azomethines of Aryl Oxazoles |
| title_sort | evaluation of in vitro anti inflammatory activity of azomethines of aryl oxazoles |
| url | http://dx.doi.org/10.1155/2011/561759 |
| work_keys_str_mv | AT vniraimathi evaluationofinvitroantiinflammatoryactivityofazomethinesofaryloxazoles AT ajeradsuresh evaluationofinvitroantiinflammatoryactivityofazomethinesofaryloxazoles AT tlatha evaluationofinvitroantiinflammatoryactivityofazomethinesofaryloxazoles |