Addressing challenges in pediatric thrombosis: a comprehensive guideline development
BackgroundPediatric thrombosis is a relatively rare but severe condition in the field of pediatrics, with far-reaching consequences. Recent studies have indicated a rising incidence of this disease in children over the years. Additionally, the pharmacological treatment of thrombotic diseases in chil...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1519517/full |
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| author | Yin Wang Qinan Yin Jiangting Liao Na Wang Li Li Siyan Li Qingxia Zhang Feifei Yu Jianchun Luo Hongmei Wang Die Hu Wenyi Li Biao Li Jingjing Chen Limei Dong Min Luo Yu Yan Lie Dong Zheng Ding Xi Wei Jiadan Yang Shenglan Tan Lian Li Xi Zheng Liuyun Wu Yong Yang Linan Zeng Jinqi Li Lizhu Han Yuan Bian |
| author_facet | Yin Wang Qinan Yin Jiangting Liao Na Wang Li Li Siyan Li Qingxia Zhang Feifei Yu Jianchun Luo Hongmei Wang Die Hu Wenyi Li Biao Li Jingjing Chen Limei Dong Min Luo Yu Yan Lie Dong Zheng Ding Xi Wei Jiadan Yang Shenglan Tan Lian Li Xi Zheng Liuyun Wu Yong Yang Linan Zeng Jinqi Li Lizhu Han Yuan Bian |
| author_sort | Yin Wang |
| collection | DOAJ |
| description | BackgroundPediatric thrombosis is a relatively rare but severe condition in the field of pediatrics, with far-reaching consequences. Recent studies have indicated a rising incidence of this disease in children over the years. Additionally, the pharmacological treatment of thrombotic diseases in children faces numerous challenges. Due to significant physiological differences between children and adults, guidelines for the prevention and treatment of thrombotic diseases in adults cannot be directly applied to pediatric patients.PurposeA systematic review of the existing evidence-based medical literature should be conducted to propose pharmacological prevention and treatment recommendations for pediatric thrombotic diseases. Developing a comprehensive and practical pharmacotherapy guideline for the prevention and treatment of pediatric thrombotic diseases is essential to enhancing the rational use of medications in managing these conditions in children.MethodsThe guideline development followed the World Health Organization's (WHO) Handbook for Guideline Development. This involves systematically searching and extensively collecting data on common medication issues in the prevention and treatment of pediatric thrombosis nationwide. The Delphi method was used to survey experts and identify the clinical issues to be included. Subsequently, a systematic literature review was conducted to evaluate existing primary studies, systematic reviews, and guidelines or consensus statements from professional organizations. The quality of the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. The Delphi method was employed again to reach a consensus on the recommendations and evidence levels. This process was culminated in the development of the Guideline for Pharmacological Management of Thrombotic Diseases in Children.ResultsDuring the guideline development process, a total of 29 clinical issues were collected and evaluated by 78 experts in clinical pharmacy and clinical medicine. Through two rounds of surveys, 13 clinical issues were selected. Under the supervision of two methodologists, 13 clinical pharmacotherapy recommendations were formulated.ConclusionBy conducting a comprehensive assessment of the feasibility and safety of clinical practices, the guideline provides specific anticoagulant medication recommendations for pediatric healthcare professionals. This will help enhance the prevention and treatment of pediatric thrombosis, promoting more standardized and effective medical practices. |
| format | Article |
| id | doaj-art-0d58db9e181c439da6d718007a2d44ad |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-0d58db9e181c439da6d718007a2d44ad2025-02-06T14:07:50ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-01-011310.3389/fped.2025.15195171519517Addressing challenges in pediatric thrombosis: a comprehensive guideline developmentYin Wang0Qinan Yin1Jiangting Liao2Na Wang3Li Li4Siyan Li5Qingxia Zhang6Feifei Yu7Jianchun Luo8Hongmei Wang9Die Hu10Wenyi Li11Biao Li12Jingjing Chen13Limei Dong14Min Luo15Yu Yan16Lie Dong17Zheng Ding18Xi Wei19Jiadan Yang20Shenglan Tan21Lian Li22Xi Zheng23Liuyun Wu24Yong Yang25Linan Zeng26Jinqi Li27Lizhu Han28Yuan Bian29Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Pharmacy, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Pharmacy, Guizhou Provincial People Hospital, Guiyang, Guizhou, ChinaSchool of Pharmaceutical Sciences, Capital Medical University, Beijing, ChinaDepartment of Pharmacy, Fengtai District Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Pharmaceutical, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Children’s Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Pharmacy, Affiliated Hospital of Southwest Jiaotong University, The Third People’s Hospital of Chengdu, Chengdu, Sichuan, China0Department of Pharmacy, Qianwei County People’s Hospital, Leshan, Sichuan, China1Department of Pharmacy, The People’s Hospital of Leshan, Leshan, Sichuan, China2Department of Pharmacy/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China3Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China4Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, China4Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Pharmacy, Affiliated Hospital of Southwest Jiaotong University, The Third People’s Hospital of Chengdu, Chengdu, Sichuan, China5Department of Pharmacy, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China6Department of Pharmacy, Third Affiliated Hospital of Naval Medical University, Shanghai, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China7Department of Pharmacy, Second Xiangya Hospital of Central South University, Changsha, Hunan, China8Department of Pharmacy, The Fourth People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China2Department of Pharmacy/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaDepartment of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaBackgroundPediatric thrombosis is a relatively rare but severe condition in the field of pediatrics, with far-reaching consequences. Recent studies have indicated a rising incidence of this disease in children over the years. Additionally, the pharmacological treatment of thrombotic diseases in children faces numerous challenges. Due to significant physiological differences between children and adults, guidelines for the prevention and treatment of thrombotic diseases in adults cannot be directly applied to pediatric patients.PurposeA systematic review of the existing evidence-based medical literature should be conducted to propose pharmacological prevention and treatment recommendations for pediatric thrombotic diseases. Developing a comprehensive and practical pharmacotherapy guideline for the prevention and treatment of pediatric thrombotic diseases is essential to enhancing the rational use of medications in managing these conditions in children.MethodsThe guideline development followed the World Health Organization's (WHO) Handbook for Guideline Development. This involves systematically searching and extensively collecting data on common medication issues in the prevention and treatment of pediatric thrombosis nationwide. The Delphi method was used to survey experts and identify the clinical issues to be included. Subsequently, a systematic literature review was conducted to evaluate existing primary studies, systematic reviews, and guidelines or consensus statements from professional organizations. The quality of the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. The Delphi method was employed again to reach a consensus on the recommendations and evidence levels. This process was culminated in the development of the Guideline for Pharmacological Management of Thrombotic Diseases in Children.ResultsDuring the guideline development process, a total of 29 clinical issues were collected and evaluated by 78 experts in clinical pharmacy and clinical medicine. Through two rounds of surveys, 13 clinical issues were selected. Under the supervision of two methodologists, 13 clinical pharmacotherapy recommendations were formulated.ConclusionBy conducting a comprehensive assessment of the feasibility and safety of clinical practices, the guideline provides specific anticoagulant medication recommendations for pediatric healthcare professionals. This will help enhance the prevention and treatment of pediatric thrombosis, promoting more standardized and effective medical practices.https://www.frontiersin.org/articles/10.3389/fped.2025.1519517/fullpediatric thrombosisrational drug usethrombosis prevention and treatmentpharmaceutical practice guidelineanticoagulation |
| spellingShingle | Yin Wang Qinan Yin Jiangting Liao Na Wang Li Li Siyan Li Qingxia Zhang Feifei Yu Jianchun Luo Hongmei Wang Die Hu Wenyi Li Biao Li Jingjing Chen Limei Dong Min Luo Yu Yan Lie Dong Zheng Ding Xi Wei Jiadan Yang Shenglan Tan Lian Li Xi Zheng Liuyun Wu Yong Yang Linan Zeng Jinqi Li Lizhu Han Yuan Bian Addressing challenges in pediatric thrombosis: a comprehensive guideline development Frontiers in Pediatrics pediatric thrombosis rational drug use thrombosis prevention and treatment pharmaceutical practice guideline anticoagulation |
| title | Addressing challenges in pediatric thrombosis: a comprehensive guideline development |
| title_full | Addressing challenges in pediatric thrombosis: a comprehensive guideline development |
| title_fullStr | Addressing challenges in pediatric thrombosis: a comprehensive guideline development |
| title_full_unstemmed | Addressing challenges in pediatric thrombosis: a comprehensive guideline development |
| title_short | Addressing challenges in pediatric thrombosis: a comprehensive guideline development |
| title_sort | addressing challenges in pediatric thrombosis a comprehensive guideline development |
| topic | pediatric thrombosis rational drug use thrombosis prevention and treatment pharmaceutical practice guideline anticoagulation |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1519517/full |
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