Integral approach to organelle profiling in human iPSC-derived cardiomyocytes enhances in vitro cardiac safety classification of known cardiotoxic compounds

Integral approach to organelle profiling in human iPSC-derived cardiomyocytes enhances in vitro cardiac safety classification of known cardiotoxic compounds

IntroductionEfficient preclinical prediction of cardiovascular side effects poses a pivotal challenge for the pharmaceutical industry. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are becoming increasingly important in this field due to inaccessibility of human native cardi...

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Bibliographic Details
Main Authors: Brigitta R. Szabo, Jeroen Stein, Anna Savchenko, Thomas Hutschalik, Filip Van Nieuwerburgh, Tim Meese, Georgios Kosmidis, Paul G. A. Volders, Elena Matsa
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Toxicology
Subjects:
hiPSC-derived cardiomyocytes
organelle profiling
cardiac safety
in vitro drug testing
fluorescence microscopy
cell painting
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2025.1644119/full
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