Deletion of RAP1 affects iron homeostasis, azole resistance, and virulence in Candida albicans

Deletion of RAP1 affects iron homeostasis, azole resistance, and virulence in Candida albicans

ABSTRACT Rap1 is a DNA-binding protein conserved from yeast to mammals for its role in telomeric maintenance. Here, to explore additional functions of Candida albicans Rap1, we performed RNA sequencing analysis. Experimental validations further showed that Rap1 plays a role in iron regulation, espec...

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Main Authors: Min-Chi Yang, Wei-Luen Huang, Hsuan-Yu Chen, Shin-Huey Lin, Yu-Shan Chang, Kuo-Yun Tseng, Hsiu-Jung Lo, I-Ching Wang, Chi-Jan Lin, Chung-Yu Lan
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mSphere
Subjects:
Candida albicans
Rap1
iron acquisition
iron utilization
virulence
fluconazole susceptibility
Online Access:https://journals.asm.org/doi/10.1128/msphere.00155-25
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https://journals.asm.org/doi/10.1128/msphere.00155-25

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