Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies
In the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest. Therapeutic interventions that promote tissue and organ regeneration have as primary objective the selective control of gene expression in ad...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/6093601 |
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| _version_ | 1832549558521954304 |
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| author | Silvia Consalvi Martina Sandoná Valentina Saccone |
| author_facet | Silvia Consalvi Martina Sandoná Valentina Saccone |
| author_sort | Silvia Consalvi |
| collection | DOAJ |
| description | In the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest. Therapeutic interventions that promote tissue and organ regeneration have as primary objective the selective control of gene expression in adult stem cells. This requires a deep understanding of the epigenetic mechanisms controlling transcriptional programs in tissue progenitors. This review attempts to elucidate the principle epigenetic regulations responsible of stem cells differentiation. In particular we focus on the current understanding of the epigenetic networks that regulate differentiation of muscle progenitors by the concerted action of chromatin-modifying enzymes and noncoding RNAs. The novel exciting role of exosome-bound microRNA in mediating epigenetic information transfer is also discussed. Finally we show an overview of the epigenetic strategies and therapies that aim to potentiate muscle regeneration and counteract the progression of Duchenne Muscular Dystrophy (DMD). |
| format | Article |
| id | doaj-art-0d412742e4eb42109bacc66e3cce9edd |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-0d412742e4eb42109bacc66e3cce9edd2025-02-03T06:10:54ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/60936016093601Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical TherapiesSilvia Consalvi0Martina Sandoná1Valentina Saccone2IRCSS, Fondazione Santa Lucia, Via del Fosso di Fiorano 64, 00143 Roma, ItalyIRCSS, Fondazione Santa Lucia, Via del Fosso di Fiorano 64, 00143 Roma, ItalyIRCSS, Fondazione Santa Lucia, Via del Fosso di Fiorano 64, 00143 Roma, ItalyIn the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest. Therapeutic interventions that promote tissue and organ regeneration have as primary objective the selective control of gene expression in adult stem cells. This requires a deep understanding of the epigenetic mechanisms controlling transcriptional programs in tissue progenitors. This review attempts to elucidate the principle epigenetic regulations responsible of stem cells differentiation. In particular we focus on the current understanding of the epigenetic networks that regulate differentiation of muscle progenitors by the concerted action of chromatin-modifying enzymes and noncoding RNAs. The novel exciting role of exosome-bound microRNA in mediating epigenetic information transfer is also discussed. Finally we show an overview of the epigenetic strategies and therapies that aim to potentiate muscle regeneration and counteract the progression of Duchenne Muscular Dystrophy (DMD).http://dx.doi.org/10.1155/2016/6093601 |
| spellingShingle | Silvia Consalvi Martina Sandoná Valentina Saccone Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies Stem Cells International |
| title | Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies |
| title_full | Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies |
| title_fullStr | Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies |
| title_full_unstemmed | Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies |
| title_short | Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies |
| title_sort | epigenetic reprogramming of muscle progenitors inspiration for clinical therapies |
| url | http://dx.doi.org/10.1155/2016/6093601 |
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