Associations between dry eye disease and sleep quality: a cross-sectional analysis
Background/aims To investigate relationships between dry eye (DE) disease and sleep quality, with a focus on which aspects of sleep most closely relate to DE.Methods 141 veterans (mean age: 56±5) seen at the Miami Veterans Affairs eye clinic filled out questionnaires to quantify the severity of DE s...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2024-08-01
|
| Series: | BMJ Open Ophthalmology |
| Online Access: | https://bmjophth.bmj.com/content/9/1/e001584.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832086621451714560 |
|---|---|
| author | Anat Galor Kimberly Cabrera Mohammad Ayoubi Elyana Vittoria Tessa Locatelli Simran Mangwani-Mordani |
| author_facet | Anat Galor Kimberly Cabrera Mohammad Ayoubi Elyana Vittoria Tessa Locatelli Simran Mangwani-Mordani |
| author_sort | Anat Galor |
| collection | DOAJ |
| description | Background/aims To investigate relationships between dry eye (DE) disease and sleep quality, with a focus on which aspects of sleep most closely relate to DE.Methods 141 veterans (mean age: 56±5) seen at the Miami Veterans Affairs eye clinic filled out questionnaires to quantify the severity of DE symptoms (5-Item Dry Eye Questionnaire (DEQ-5) and Ocular Surface Disease Index (OSDI)) and ocular pain (Numerical Rating Scale (NRS) and Neuropathic Pain Symptom Inventory modified for the Eye (NPSI-E)). All individuals also underwent an ocular surface examination. Aspects of sleep quality were assessed using the Pittsburgh Sleep Quality Index (PSQI). DE metrics were examined by PSQI scores and subscores.Results Most participants (76%) reported mild or greater DE symptoms (DEQ-5 ≥6). Overall, ocular symptoms were more related to sleep metrics than signs. The strongest DE symptom association was between the OSDI and sleep disturbances (PSQI subscore 5, r=0.49, p<0.0005). For DE signs, ocular surface inflammation and meibum quality were related to subjective sleep quality (PSQI subscore 1, r=0.29, p=0.03, for both). On linear regression analyses, most ocular symptom questionnaires remained associated with sleep disturbances (PSQI subscore 5: NRS (r=0.52, p<0.0005), DEQ-5 (r=0.36, p<0.0005), and OSDI (r=0.31, p<0.0005)). For DE signs, ocular surface inflammation and meibum quality remained associated with subjective sleep quality (r=0.26, p=0.01; r=0.46, p<0.0005, respectively).Conclusion DE symptom and ocular pain intensity were closely related to sleep metrics, most strongly to sleep disturbances. Relationships were weaker for DE signs, with subjective sleep quality relating to inflammation and meibum quality. |
| format | Article |
| id | doaj-art-0d33157f8e0543609f7bd7d2f6b4d9cc |
| institution | Kabale University |
| issn | 2397-3269 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Ophthalmology |
| spelling | doaj-art-0d33157f8e0543609f7bd7d2f6b4d9cc2025-02-06T10:00:15ZengBMJ Publishing GroupBMJ Open Ophthalmology2397-32692024-08-019110.1136/bmjophth-2023-001584Associations between dry eye disease and sleep quality: a cross-sectional analysisAnat Galor0Kimberly Cabrera1Mohammad Ayoubi2Elyana Vittoria Tessa Locatelli3Simran Mangwani-Mordani4Department of Ophthalmology, Bruce W Carter Department of Veterans Affairs Medical Center, Miami, Florida, USAResearch, Bruce W Carter Department of Veterans Affairs Medical Center, Miami, Florida, USAUniversity of Miami Miller School of Medicine, Miami, Florida, USADepartment of Ophthalmology, Bruce W Carter Department of Veterans Affairs Medical Center, Miami, Florida, USADepartment of Ophthalmology, Bruce W Carter Department of Veterans Affairs Medical Center, Miami, Florida, USABackground/aims To investigate relationships between dry eye (DE) disease and sleep quality, with a focus on which aspects of sleep most closely relate to DE.Methods 141 veterans (mean age: 56±5) seen at the Miami Veterans Affairs eye clinic filled out questionnaires to quantify the severity of DE symptoms (5-Item Dry Eye Questionnaire (DEQ-5) and Ocular Surface Disease Index (OSDI)) and ocular pain (Numerical Rating Scale (NRS) and Neuropathic Pain Symptom Inventory modified for the Eye (NPSI-E)). All individuals also underwent an ocular surface examination. Aspects of sleep quality were assessed using the Pittsburgh Sleep Quality Index (PSQI). DE metrics were examined by PSQI scores and subscores.Results Most participants (76%) reported mild or greater DE symptoms (DEQ-5 ≥6). Overall, ocular symptoms were more related to sleep metrics than signs. The strongest DE symptom association was between the OSDI and sleep disturbances (PSQI subscore 5, r=0.49, p<0.0005). For DE signs, ocular surface inflammation and meibum quality were related to subjective sleep quality (PSQI subscore 1, r=0.29, p=0.03, for both). On linear regression analyses, most ocular symptom questionnaires remained associated with sleep disturbances (PSQI subscore 5: NRS (r=0.52, p<0.0005), DEQ-5 (r=0.36, p<0.0005), and OSDI (r=0.31, p<0.0005)). For DE signs, ocular surface inflammation and meibum quality remained associated with subjective sleep quality (r=0.26, p=0.01; r=0.46, p<0.0005, respectively).Conclusion DE symptom and ocular pain intensity were closely related to sleep metrics, most strongly to sleep disturbances. Relationships were weaker for DE signs, with subjective sleep quality relating to inflammation and meibum quality.https://bmjophth.bmj.com/content/9/1/e001584.full |
| spellingShingle | Anat Galor Kimberly Cabrera Mohammad Ayoubi Elyana Vittoria Tessa Locatelli Simran Mangwani-Mordani Associations between dry eye disease and sleep quality: a cross-sectional analysis BMJ Open Ophthalmology |
| title | Associations between dry eye disease and sleep quality: a cross-sectional analysis |
| title_full | Associations between dry eye disease and sleep quality: a cross-sectional analysis |
| title_fullStr | Associations between dry eye disease and sleep quality: a cross-sectional analysis |
| title_full_unstemmed | Associations between dry eye disease and sleep quality: a cross-sectional analysis |
| title_short | Associations between dry eye disease and sleep quality: a cross-sectional analysis |
| title_sort | associations between dry eye disease and sleep quality a cross sectional analysis |
| url | https://bmjophth.bmj.com/content/9/1/e001584.full |
| work_keys_str_mv | AT anatgalor associationsbetweendryeyediseaseandsleepqualityacrosssectionalanalysis AT kimberlycabrera associationsbetweendryeyediseaseandsleepqualityacrosssectionalanalysis AT mohammadayoubi associationsbetweendryeyediseaseandsleepqualityacrosssectionalanalysis AT elyanavittoriatessalocatelli associationsbetweendryeyediseaseandsleepqualityacrosssectionalanalysis AT simranmangwanimordani associationsbetweendryeyediseaseandsleepqualityacrosssectionalanalysis |