Application of Stem Cell Therapy for ACL Graft Regeneration
Graft regeneration after anterior cruciate ligament (ACL) reconstruction surgery is a complex three-stage process, which usually takes a long duration and often results in fibrous scar tissue formation that exerts a detrimental impact on the patients’ prognosis. Hence, as a regeneration technique, s...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/6641818 |
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| _version_ | 1832563684041293824 |
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| author | Canlong Wang Yejun Hu Shichen Zhang Dengfeng Ruan Zizhan Huang Peiwen He Honglu Cai Boon Chin Heng Xiao Chen Weiliang Shen |
| author_facet | Canlong Wang Yejun Hu Shichen Zhang Dengfeng Ruan Zizhan Huang Peiwen He Honglu Cai Boon Chin Heng Xiao Chen Weiliang Shen |
| author_sort | Canlong Wang |
| collection | DOAJ |
| description | Graft regeneration after anterior cruciate ligament (ACL) reconstruction surgery is a complex three-stage process, which usually takes a long duration and often results in fibrous scar tissue formation that exerts a detrimental impact on the patients’ prognosis. Hence, as a regeneration technique, stem cell transplantation has attracted increasing attention. Several different stem cell types have been utilized in animal experiments, and almost all of these have shown good capacity in improving tendon-bone regeneration. Various differentiation inducers have been widely applied together with stem cells to enhance specific lineage differentiation, such as recombinant gene transfection, growth factors, and biomaterials. Among the various different types of stem cells, bone marrow-derived mesenchymal stem cells (BMSCs) have been investigated the most, while ligament stem progenitor cells (LDSCs) have demonstrated the best potential in generating tendon/ligament lineage cells. In the clinic, 4 relevant completed trials have been reported, but only one trial with BMSCs showed improved outcomes, while 5 relevant trials are still in progress. This review describes the process of ACL graft regeneration after implantation and summarizes the current application of stem cells from bench to bedside, as well as discusses future perspectives in this field. |
| format | Article |
| id | doaj-art-0d104c442bb245b2a4f85823321cfda8 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-0d104c442bb245b2a4f85823321cfda82025-02-03T01:12:53ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/66418186641818Application of Stem Cell Therapy for ACL Graft RegenerationCanlong Wang0Yejun Hu1Shichen Zhang2Dengfeng Ruan3Zizhan Huang4Peiwen He5Honglu Cai6Boon Chin Heng7Xiao Chen8Weiliang Shen9Department of Orthopedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang 310009, ChinaDepartment of Orthopedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang 310009, ChinaOrthopaedics Research Institute of Zhejiang University, Zhejiang, ChinaDepartment of Orthopedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang 310009, ChinaDepartment of Orthopedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang 310009, ChinaDepartment of Orthopedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang 310009, ChinaDepartment of Orthopedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang 310009, ChinaCentral Laboratory, Peking University School of Stomatology, Bejing 100081, ChinaOrthopaedics Research Institute of Zhejiang University, Zhejiang, ChinaDepartment of Orthopedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang 310009, ChinaGraft regeneration after anterior cruciate ligament (ACL) reconstruction surgery is a complex three-stage process, which usually takes a long duration and often results in fibrous scar tissue formation that exerts a detrimental impact on the patients’ prognosis. Hence, as a regeneration technique, stem cell transplantation has attracted increasing attention. Several different stem cell types have been utilized in animal experiments, and almost all of these have shown good capacity in improving tendon-bone regeneration. Various differentiation inducers have been widely applied together with stem cells to enhance specific lineage differentiation, such as recombinant gene transfection, growth factors, and biomaterials. Among the various different types of stem cells, bone marrow-derived mesenchymal stem cells (BMSCs) have been investigated the most, while ligament stem progenitor cells (LDSCs) have demonstrated the best potential in generating tendon/ligament lineage cells. In the clinic, 4 relevant completed trials have been reported, but only one trial with BMSCs showed improved outcomes, while 5 relevant trials are still in progress. This review describes the process of ACL graft regeneration after implantation and summarizes the current application of stem cells from bench to bedside, as well as discusses future perspectives in this field.http://dx.doi.org/10.1155/2021/6641818 |
| spellingShingle | Canlong Wang Yejun Hu Shichen Zhang Dengfeng Ruan Zizhan Huang Peiwen He Honglu Cai Boon Chin Heng Xiao Chen Weiliang Shen Application of Stem Cell Therapy for ACL Graft Regeneration Stem Cells International |
| title | Application of Stem Cell Therapy for ACL Graft Regeneration |
| title_full | Application of Stem Cell Therapy for ACL Graft Regeneration |
| title_fullStr | Application of Stem Cell Therapy for ACL Graft Regeneration |
| title_full_unstemmed | Application of Stem Cell Therapy for ACL Graft Regeneration |
| title_short | Application of Stem Cell Therapy for ACL Graft Regeneration |
| title_sort | application of stem cell therapy for acl graft regeneration |
| url | http://dx.doi.org/10.1155/2021/6641818 |
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