Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH Responsiveness
Diblock copolymers (mPEG-b-PDPA), which were designed to possess pH-sensitivity as well as amphipathy, were used as an intelligent lock in the liposomal membrane. The so-called pH-sensitive liposomes were prepared by simple mixing of the synthesized mPEG-b-PDPA with phospholipids and cholesterol. Fl...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2016/5879428 |
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| author | Tian Xia Weiju Hao Yazhuo Shang Shouhong Xu Honglai Liu |
| author_facet | Tian Xia Weiju Hao Yazhuo Shang Shouhong Xu Honglai Liu |
| author_sort | Tian Xia |
| collection | DOAJ |
| description | Diblock copolymers (mPEG-b-PDPA), which were designed to possess pH-sensitivity as well as amphipathy, were used as an intelligent lock in the liposomal membrane. The so-called pH-sensitive liposomes were prepared by simple mixing of the synthesized mPEG-b-PDPA with phospholipids and cholesterol. Fluorescence polarization at pH 7.4 showed that the membrane stability of the hybrid liposome was significantly increased compared with the pure liposome. Therefore, in the neutral environment, the leakage of doxorubicin (DOX) was inhibited. However, when pH decreased to 6.0, DOX release rate increased by 60% due to the escape of copolymer. The effects of the membrane composition and the PDPA segment length on bilayer membrane functions were investigated. These results revealed that the synthesized copolymers increased the difference in DOX cumulative release between pH 7.4 and 6.0, that is, improved the pH-controllability of the drug release from hybrid liposomes. |
| format | Article |
| id | doaj-art-0d09ef8f156141a08c7806a93b39a671 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-0d09ef8f156141a08c7806a93b39a6712025-02-03T06:13:10ZengWileyInternational Journal of Polymer Science1687-94221687-94302016-01-01201610.1155/2016/58794285879428Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH ResponsivenessTian Xia0Weiju Hao1Yazhuo Shang2Shouhong Xu3Honglai Liu4Key Laboratory for Advanced Materials and Department of Chemistry, East China University of Science and Technology, Shanghai 200237, ChinaKey Laboratory for Advanced Materials and Department of Chemistry, East China University of Science and Technology, Shanghai 200237, ChinaKey Laboratory for Advanced Materials and Department of Chemistry, East China University of Science and Technology, Shanghai 200237, ChinaKey Laboratory for Advanced Materials and Department of Chemistry, East China University of Science and Technology, Shanghai 200237, ChinaKey Laboratory for Advanced Materials and Department of Chemistry, East China University of Science and Technology, Shanghai 200237, ChinaDiblock copolymers (mPEG-b-PDPA), which were designed to possess pH-sensitivity as well as amphipathy, were used as an intelligent lock in the liposomal membrane. The so-called pH-sensitive liposomes were prepared by simple mixing of the synthesized mPEG-b-PDPA with phospholipids and cholesterol. Fluorescence polarization at pH 7.4 showed that the membrane stability of the hybrid liposome was significantly increased compared with the pure liposome. Therefore, in the neutral environment, the leakage of doxorubicin (DOX) was inhibited. However, when pH decreased to 6.0, DOX release rate increased by 60% due to the escape of copolymer. The effects of the membrane composition and the PDPA segment length on bilayer membrane functions were investigated. These results revealed that the synthesized copolymers increased the difference in DOX cumulative release between pH 7.4 and 6.0, that is, improved the pH-controllability of the drug release from hybrid liposomes.http://dx.doi.org/10.1155/2016/5879428 |
| spellingShingle | Tian Xia Weiju Hao Yazhuo Shang Shouhong Xu Honglai Liu Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH Responsiveness International Journal of Polymer Science |
| title | Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH Responsiveness |
| title_full | Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH Responsiveness |
| title_fullStr | Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH Responsiveness |
| title_full_unstemmed | Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH Responsiveness |
| title_short | Incorporation of Amphipathic Diblock Copolymer in Lipid Bilayer for Improving pH Responsiveness |
| title_sort | incorporation of amphipathic diblock copolymer in lipid bilayer for improving ph responsiveness |
| url | http://dx.doi.org/10.1155/2016/5879428 |
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