Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review
Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, antiproliferative, cytotoxic, antiviral, antifungal, and antineoplastic propertie...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/561971 |
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| author | Sumeyya Akyol Veli Ugurcu Aynur Altuntas Rukiye Hasgul Ozlem Cakmak Omer Akyol |
| author_facet | Sumeyya Akyol Veli Ugurcu Aynur Altuntas Rukiye Hasgul Ozlem Cakmak Omer Akyol |
| author_sort | Sumeyya Akyol |
| collection | DOAJ |
| description | Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, antiproliferative, cytotoxic, antiviral, antifungal, and antineoplastic properties. One of the most studied organs for the effects of CAPE is the kidney, particularly in the capacity of this ester to decrease the nephrotoxicity induced by several drugs and the oxidative injury after ischemia/reperfusion (I/R). In this review, we summarized and critically evaluated the current knowledge regarding the protective effect of CAPE in nephrotoxicity induced by several special medicines such as cisplatin, doxorubicin, cyclosporine, gentamycin, methotrexate, and other causes leading to oxidative renal injury, namely, I/R models and senility. |
| format | Article |
| id | doaj-art-0d03f4f286bf4cb494ffdcac2894e42c |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-0d03f4f286bf4cb494ffdcac2894e42c2025-02-03T05:43:54ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/561971561971Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic ReviewSumeyya Akyol0Veli Ugurcu1Aynur Altuntas2Rukiye Hasgul3Ozlem Cakmak4Omer Akyol5Division of Medical Laboratory Techniques, Vocational School of Health Sciences, Turgut Ozal University, Çeşme Durağı Spor Kompleksi Arkası, Ostim, Yenimahalle, 06370 Ankara, TurkeyPrivate Bilecik Orhangazi Dialysis Center, Bilecik, TurkeyAnkara Branch of Council of Forensic Medicine, Ankara, TurkeyDivision of Medical Laboratory Techniques, Vocational School of Health Sciences, Turgut Ozal University, Çeşme Durağı Spor Kompleksi Arkası, Ostim, Yenimahalle, 06370 Ankara, TurkeyDepartment of Biology, Faculty of Education, Gazi University, Ankara, TurkeyDepartment of Medical Biochemistry, Medical Faculty, Hacettepe University, Ankara, TurkeyCaffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, antiproliferative, cytotoxic, antiviral, antifungal, and antineoplastic properties. One of the most studied organs for the effects of CAPE is the kidney, particularly in the capacity of this ester to decrease the nephrotoxicity induced by several drugs and the oxidative injury after ischemia/reperfusion (I/R). In this review, we summarized and critically evaluated the current knowledge regarding the protective effect of CAPE in nephrotoxicity induced by several special medicines such as cisplatin, doxorubicin, cyclosporine, gentamycin, methotrexate, and other causes leading to oxidative renal injury, namely, I/R models and senility.http://dx.doi.org/10.1155/2014/561971 |
| spellingShingle | Sumeyya Akyol Veli Ugurcu Aynur Altuntas Rukiye Hasgul Ozlem Cakmak Omer Akyol Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review The Scientific World Journal |
| title | Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review |
| title_full | Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review |
| title_fullStr | Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review |
| title_full_unstemmed | Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review |
| title_short | Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review |
| title_sort | caffeic acid phenethyl ester as a protective agent against nephrotoxicity and or oxidative kidney damage a detailed systematic review |
| url | http://dx.doi.org/10.1155/2014/561971 |
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