Effect of Periodontal Therapy on Crevicular Fluid Interleukin-6 and Interleukin-8 Levels in Chronic Periodontitis
Purpose. The aim of this study was to analyse the levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) in gingival crevicular fluid (GCF) of patients with chronic periodontitis prior to and following surgical and/or nonsurgical periodontal therapy for a period of 32 weeks. Methods. GCF samples we...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2012/362905 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556379383005184 |
|---|---|
| author | Paschalina Goutoudi Evdoxia Diza Malamatenia Arvanitidou |
| author_facet | Paschalina Goutoudi Evdoxia Diza Malamatenia Arvanitidou |
| author_sort | Paschalina Goutoudi |
| collection | DOAJ |
| description | Purpose. The aim of this study was to analyse the levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) in gingival crevicular fluid (GCF) of patients with chronic periodontitis prior to and following surgical and/or nonsurgical periodontal therapy for a period of 32 weeks. Methods. GCF samples were obtained from 24 nondiseased and 72 diseased sites of 12 periodontal patients prior to as well as at 6, 16, and 32 weeks following non-surgical and surgical periodontal therapy. IL-6 and IL-8 levels were determined by enzyme-linked immunosorbent assay (ELISA). Results. Periodontal treatment improved all clinical parameters. Both treatment modalities resulted in similar IL-6 as well as IL-8 levels. Mean IL-6 and IL-8 concentrations were significantly higher in non-diseased compared to diseased sites and increased significantly following treatment in diseased sites. Mean total amounts of IL-6 and IL-8 (TAIL-6, TAIL-8) did not differ significantly between diseased and nondiseased sites, while following therapy TAIL-8 levels decreased significantly. Conclusions. The data suggest that periodontal therapy reduced the levels of IL-8 in GCF. However, a strong relationship between IL-6, IL-8 amounts in GCF and periodontal destruction and inflammation was not found. |
| format | Article |
| id | doaj-art-0cf6e439a14b4ba5b537c9773c3c8051 |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-0cf6e439a14b4ba5b537c9773c3c80512025-02-03T05:45:35ZengWileyInternational Journal of Dentistry1687-87281687-87362012-01-01201210.1155/2012/362905362905Effect of Periodontal Therapy on Crevicular Fluid Interleukin-6 and Interleukin-8 Levels in Chronic PeriodontitisPaschalina Goutoudi0Evdoxia Diza1Malamatenia Arvanitidou2Department of Preventive Dentistry, Periodontology and Implant Biology, Dental School, Aristotle University of Thessaloniki, 70 Tsimiski Street, 54622 Thessaloniki, GreeceDepartment of Microbiology, Medical School, Aristotle University of Thessaloniki, 541 24 Thessaloniki, GreeceDepartment of Hygiene, Medical School, Aristotle University of Thessaloniki, 541 24 Thessaloniki, GreecePurpose. The aim of this study was to analyse the levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) in gingival crevicular fluid (GCF) of patients with chronic periodontitis prior to and following surgical and/or nonsurgical periodontal therapy for a period of 32 weeks. Methods. GCF samples were obtained from 24 nondiseased and 72 diseased sites of 12 periodontal patients prior to as well as at 6, 16, and 32 weeks following non-surgical and surgical periodontal therapy. IL-6 and IL-8 levels were determined by enzyme-linked immunosorbent assay (ELISA). Results. Periodontal treatment improved all clinical parameters. Both treatment modalities resulted in similar IL-6 as well as IL-8 levels. Mean IL-6 and IL-8 concentrations were significantly higher in non-diseased compared to diseased sites and increased significantly following treatment in diseased sites. Mean total amounts of IL-6 and IL-8 (TAIL-6, TAIL-8) did not differ significantly between diseased and nondiseased sites, while following therapy TAIL-8 levels decreased significantly. Conclusions. The data suggest that periodontal therapy reduced the levels of IL-8 in GCF. However, a strong relationship between IL-6, IL-8 amounts in GCF and periodontal destruction and inflammation was not found.http://dx.doi.org/10.1155/2012/362905 |
| spellingShingle | Paschalina Goutoudi Evdoxia Diza Malamatenia Arvanitidou Effect of Periodontal Therapy on Crevicular Fluid Interleukin-6 and Interleukin-8 Levels in Chronic Periodontitis International Journal of Dentistry |
| title | Effect of Periodontal Therapy on Crevicular Fluid Interleukin-6 and Interleukin-8 Levels in Chronic Periodontitis |
| title_full | Effect of Periodontal Therapy on Crevicular Fluid Interleukin-6 and Interleukin-8 Levels in Chronic Periodontitis |
| title_fullStr | Effect of Periodontal Therapy on Crevicular Fluid Interleukin-6 and Interleukin-8 Levels in Chronic Periodontitis |
| title_full_unstemmed | Effect of Periodontal Therapy on Crevicular Fluid Interleukin-6 and Interleukin-8 Levels in Chronic Periodontitis |
| title_short | Effect of Periodontal Therapy on Crevicular Fluid Interleukin-6 and Interleukin-8 Levels in Chronic Periodontitis |
| title_sort | effect of periodontal therapy on crevicular fluid interleukin 6 and interleukin 8 levels in chronic periodontitis |
| url | http://dx.doi.org/10.1155/2012/362905 |
| work_keys_str_mv | AT paschalinagoutoudi effectofperiodontaltherapyoncrevicularfluidinterleukin6andinterleukin8levelsinchronicperiodontitis AT evdoxiadiza effectofperiodontaltherapyoncrevicularfluidinterleukin6andinterleukin8levelsinchronicperiodontitis AT malamateniaarvanitidou effectofperiodontaltherapyoncrevicularfluidinterleukin6andinterleukin8levelsinchronicperiodontitis |