Redundant Vasodilator Pathways Underlying Radial Artery Flow-Mediated Dilation Are Preserved in Healthy Aging
Background. Blocking nitric oxide (NO) and vasodilator prostanoids (PN) does not consistently reduce flow-mediated dilation (FMD) in young adults. The impact of aging on the contribution of NO and PG to FMD is unknown. Methods. FMD was measured in older adults (n=10, 65±3 y) after arterial infusion...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2014/876125 |
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| author | Kevin D. Ballard Michael E. Tschakovsky Amanda L. Zaleski Donna M. Polk Paul D. Thompson Francis J. Kiernan Beth A. Parker |
| author_facet | Kevin D. Ballard Michael E. Tschakovsky Amanda L. Zaleski Donna M. Polk Paul D. Thompson Francis J. Kiernan Beth A. Parker |
| author_sort | Kevin D. Ballard |
| collection | DOAJ |
| description | Background. Blocking nitric oxide (NO) and vasodilator prostanoids (PN) does not consistently reduce flow-mediated dilation (FMD) in young adults. The impact of aging on the contribution of NO and PG to FMD is unknown. Methods. FMD was measured in older adults (n=10, 65±3 y) after arterial infusion of saline, N(G)-monomethyl-L-arginine (L-NMMA), and ketorolac + L-NMMA. Data were compared to published data in young adults. Results. L-NMMA reduced FMD in older adults (8.9±3.6 to 5.9±3.7%) although this was not statistically significant (P=0.08) and did not differ (P=0.74) from the reduction observed in young adults (10.0±3.8 to 7.6±4.7%; P=0.03). Blocking PN did not affect FMD in young or older adults. In older adults, L-NMMA reduced (n=6; range = 36–123% decrease), augmented (n=3; 10–122% increase), or did not change FMD (n=1; 0.4% increase). After PN blockade, FMD responses were reduced (n=2), augmented (n=6), or unaffected (n=1). Conclusions. NO or PN blockade did not consistently reduce FMD in healthy older adults, suggesting the existence of redundant vasodilator phenotypes as observed previously in young adults. |
| format | Article |
| id | doaj-art-0cf0814ffddd4d1a857627cfb7cda401 |
| institution | Kabale University |
| issn | 2090-2204 2090-2212 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-0cf0814ffddd4d1a857627cfb7cda4012025-02-03T05:50:08ZengWileyJournal of Aging Research2090-22042090-22122014-01-01201410.1155/2014/876125876125Redundant Vasodilator Pathways Underlying Radial Artery Flow-Mediated Dilation Are Preserved in Healthy AgingKevin D. Ballard0Michael E. Tschakovsky1Amanda L. Zaleski2Donna M. Polk3Paul D. Thompson4Francis J. Kiernan5Beth A. Parker6Division of Cardiology, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USASchool of Kinesiology and Health Studies, Queen’s University, 28 Division Street, Kingston, ON, K7L 3N6, CanadaDivision of Cardiology, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USADivision of Cardiology, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USADivision of Cardiology, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USADivision of Cardiology, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USADivision of Cardiology, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USABackground. Blocking nitric oxide (NO) and vasodilator prostanoids (PN) does not consistently reduce flow-mediated dilation (FMD) in young adults. The impact of aging on the contribution of NO and PG to FMD is unknown. Methods. FMD was measured in older adults (n=10, 65±3 y) after arterial infusion of saline, N(G)-monomethyl-L-arginine (L-NMMA), and ketorolac + L-NMMA. Data were compared to published data in young adults. Results. L-NMMA reduced FMD in older adults (8.9±3.6 to 5.9±3.7%) although this was not statistically significant (P=0.08) and did not differ (P=0.74) from the reduction observed in young adults (10.0±3.8 to 7.6±4.7%; P=0.03). Blocking PN did not affect FMD in young or older adults. In older adults, L-NMMA reduced (n=6; range = 36–123% decrease), augmented (n=3; 10–122% increase), or did not change FMD (n=1; 0.4% increase). After PN blockade, FMD responses were reduced (n=2), augmented (n=6), or unaffected (n=1). Conclusions. NO or PN blockade did not consistently reduce FMD in healthy older adults, suggesting the existence of redundant vasodilator phenotypes as observed previously in young adults.http://dx.doi.org/10.1155/2014/876125 |
| spellingShingle | Kevin D. Ballard Michael E. Tschakovsky Amanda L. Zaleski Donna M. Polk Paul D. Thompson Francis J. Kiernan Beth A. Parker Redundant Vasodilator Pathways Underlying Radial Artery Flow-Mediated Dilation Are Preserved in Healthy Aging Journal of Aging Research |
| title | Redundant Vasodilator Pathways Underlying Radial Artery Flow-Mediated Dilation Are Preserved in Healthy Aging |
| title_full | Redundant Vasodilator Pathways Underlying Radial Artery Flow-Mediated Dilation Are Preserved in Healthy Aging |
| title_fullStr | Redundant Vasodilator Pathways Underlying Radial Artery Flow-Mediated Dilation Are Preserved in Healthy Aging |
| title_full_unstemmed | Redundant Vasodilator Pathways Underlying Radial Artery Flow-Mediated Dilation Are Preserved in Healthy Aging |
| title_short | Redundant Vasodilator Pathways Underlying Radial Artery Flow-Mediated Dilation Are Preserved in Healthy Aging |
| title_sort | redundant vasodilator pathways underlying radial artery flow mediated dilation are preserved in healthy aging |
| url | http://dx.doi.org/10.1155/2014/876125 |
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